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Bacopa monnieri extracts prevent hydrogen peroxide- induced oxidative damage in a cellular model of neuroblastoma IMR32 cells

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Chinese Journal of Natural Medicines 2017年第11期15卷 834-846页

作者： Gaurav Bhatia Vikram Dhuna Kshitija Dhuna Manpreet Kaur Jatinder Singh Department of Molecular Biology and Biochemistry Guru Nanak Dev University Amritsar-143005 Punjab India Department of Biotechnology DAV College Amritsar-143006 Punjab India Department of Human Genetics Guru Nanak Dev University Amritsar-143005 Punjab India

Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide(H_2O_2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is well known for its nerve relaxing and memory enhancing properties. The present study was designed to evaluate the protective effects of extracts from Bacopa monnieri against H_2O_2 induced oxidative stress using a cellular model, neuroblastoma IMR32 cell line. The protective potential of methanolic, ethanolic, and water extracts of B. monnieri(BM-MEx, BM-EEx, and BM-WEx) was evaluated using MTT assay. Although, all the B. monnieri extracts were found to protect cells against H_2O_2-mediated stress but BM-MEx showed significantly greater protection. UPLC analysis of BM-MEx revealed various polyphenols, including quercetin, catechin, umbelliferone, and caffeic acid predominance. Further, BM-MEx was found to possess considerable greater neuroprotective potential in comparison to the standard polyphenols such as quercetin, catechin, umbelliferone, and caffeic acid. The levels of antioxidant enzymes were significantly elevated after the pretreatment of BM-MEx and quercetin. The expression levels of oxidative stress markers, such as NF200, HSP70, and mortalin, were significantly alleviated after the pretreatment of BM-MEx as shown by immunofluorescence and RT-PCR. In conclusion, the present study demonstrated the protective effects of BM-MEx, suggesting that it could be a candidate for the development of neuropathological therapeutics.

关键词： Antioxidant enzymes Bacopa monnieri H2O2 IMR32 neuroblastoma NF200 HSP70 Mortalin

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Microscopic Observation of Acid Rain Induced <i>Bacopa monnieri</i>L.

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Microscopy Research 2019年第2期7卷 11-25页

作者： Shradhanjali Behera Pramod Chandra Mishra Shyamasree Ghosh Chandan Goswami Biswajit Mallick Department of Environmental Sciences Sambalpur University Jyoti Vihar India National Green Tribunal Eastern Zone Bench Finance Centre Kolkata India School of Biological Sciences National Institute of Science Education and Research Bhubaneswar India Institute of Physics Bhubaneswar India

Acid rain (AR) has been reported to induce stress in plants affecting its productivity, growth, flowering and physiology. The molecular changes induced in plants due to the effect of acid rain or acid induced orientation or chloroplast streaming remains largely unknown. Therefore, in the current study we report for the first time the static and permanent changes in the cell of the medicinal plant Bacopa monnieri L. due to sulphur-simulated acid rain (S-SiAR). AR induced effects witnessed by the reduction of the size of starch granules and chloroplast, amount of the granules per unit area, dissolving cell walls, breaking the normal fiber, salt-induced strain in the various components of the cell. Effect of starch granule and chloroplast due to S-SiAR was analyzed using light, confocal and scanning electron microscopic techniques. The elements viz. potassium and magnesium present in the chloroplasts reveal acidic pH due to effect of S-SiAR observed by the ionization of Mg and K (to Mg2+ and K+), in which K+ induced by the effects of S-SiAR revealed a net negative Nernst potential of about -87.55 mV. Calcium is mainly present on the cell walls and responsible for binding of starch granules become ionized to Ca2+ on interacting with AR indicated by the altered Nernst potential of +137.04 mV. A net potential difference may cause the above streaming of chloroplast towards the large starch granules. From this study, we report AR-induced physiological changes in medicinal plant Bacopa monnieri L. for the first time.

关键词： Simulated Acid Rain Bacopa monnieri Chloroplast Starch Microscopy Granules SEM pH LM

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Bone density and biomechanical effects of total coumarins of Cnidium monnieri on glucocorticoids-induced osteoporosis in rats

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广东医科大学学报 1998年第Z1期 176-177页

作者： Liao Jinmin 1,Zhu Qing’an 2,Lu Haijun 2,et al ( 1Bone Biology Laboratory,Guangdong Medical College,Zhanjiang 524023 2Biomechanical Laboratory, First Military Medical University,Guangzhou 510515,China)

Bone density and biomechanical effects of total coumarins of Cnidium monnieri on glucocorticoids-induced osteoporosis in rats... 详细信息

Bone density and biomechanical effects of total coumarins of Cnidium monnieri on glucocorticoids-induced osteoporosis in rats...

关键词： osteoporosis Cnidium and biomechanical coumarins density effects in monnieri of

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前列腺素与阿斯匹林类药物的临床新应用及不良反应

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赣南医学院学报 1994年第4期14卷 326-334页

作者：孙庆伟黄诚江西赣州地区卫校药理组

前列腺素与阿斯匹林类药物的临床新应用及不良反应孙庆伟，黄诚（赣州生理学教研室３４１０００）阿斯匹林在临床上使用已有８０多年的历史，但直到１９７１年Ｖａｎｅ等发现它可抑制前列腺素（ＰＧ）合成以后，才知道它的许多药理学、... 详细信息

前列腺素与阿斯匹林类药物的临床新应用及不良反应孙庆伟，黄诚（赣州生理学教研室３４１０００）阿斯匹林在临床上使用已有８０多年的历史，但直到１９７１年Ｖａｎｅ等发现它可抑制前列腺素（ＰＧ）合成以后，才知道它的许多药理学、治疗学及毒副作用与抑制体内ＰＧ生物...

关键词： Coumarins / pharmacodynamics Total Coumarins of Cnidii monnieri Arrhythmia / chemically induced Arrhythmia/drug therapy.

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Brahmi研究与开发:一种能改善记忆的药用植物(英文)

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中国药理学与毒理学杂志 2015年第S1期29卷 13-13页

作者： KornkanokINGKANINAN NanteetipLIMPEANCHOB SakchaiWITTAYA-AREEKUL KrongkarnCHOOTIP PornnarinTAEPAWARAPRUK NuwatTAEPAWARAPRUK JintanapornWATTANATHORN SeewaboonSIREERATAWONG WarapornPUTALUN WatooPHROMPITTAYARAT HiroyukiTANAKA Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry Naresuan University Phitsanulok 65000 Thailand Faculty of Medical Sciences Naresuan University Phitsanulok 65000 Thailand Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Faculty of Medicine Chiang Mai University Chiang Mai 50200 Thailand Faculty of Pharmaceutical Sciences Khon Kaen University Khon Kaen 40002 Thailand Faculty of Public Health Naresuan University Phitsanulok 65000 Thailand Graduate School of Pharmaceutical Sciences Kyushu University Fukuoka 812-8582 Japan

OBJECTIVE Brahmi(Bacopa monnieri Wettst.,Schrophulariaceae)has been used in Ayuravedic medicine as a memory *** aimed at research and development of Brahmi for clinical use as the food supplement for memory *** The standardized extract of Brahmi has been *** neuroprotective effect of the extract was tested using in vitro and in vivo assay.A double-blinded randomized control trial of brahmi tablet was conducted in 60 middle-aged elderly *** The in vivo studies indicated that the standardized extract had neuroprotective effect at the doses of 40 and 80mg·*** escape latency time of rats in Morris water maze test was ***,the reduction of neurons and cholinergic neuron densities were *** also tested its protection effect against the beta-amyloid protein and glutamate-induced neurotoxicity in primary cortical cultured *** result demonstrated that Brahmi extract protected neurons from beta-amyloid-induced cell death,but not glutamate-induced *** standardized extract of Brahmi is formulated as a film-coated *** effect of Brahmi extract on learning and memory was studied in the middle aged and elderly *** results showed that Brahmi extract(300and 600mg·d-1)could improve quality of life in the elderly by improving the physical fitness via the increase in efficiency of postural *** also improved the psychological fitness by increasing alertness and attention resulted in the improvement of learning and *** addition,Brahmi extract could decrease depression-like *** dosage used in this study did not produce toxic and side *** The in vitro and in vivo studies suggested that brahmi is a potential medicinal plant for memory *** clinical study showed that brahmi tablet could improve physical fitness and enhance memory in healthy volunteers.

关键词： Bacopa monnieri clinical study memory neuroprotect

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