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Advances on hormone-like activity of Panax ginseng and ginsenosides

Chinese Journal of Natural Medicines 2020年第7期18卷 526-535页

作者： TIAN Mei LI Lin-Nan ZHENG Rui-Rong YANG Li WANG Zheng-Tao The MOE Key Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

Traditional Chinese medicine(TCM)has been paid much attentions due to the prevention and treatment of steroid hormone ***,the root of Panax ginseng ***(Araliaceae),is one of the most valuable herbs in complementary and alternative medicines around the world.A series of dammarane triterpenoid saponins,also known as phytosteroids,were reported as the primary ingredients of Ginseng,and indicated broad spectral pharmacological actions,including anti-cancer,anti-inflammation and *** skeletons of the dammarane triterpenoid aglycone are structurally similar to the steroid *** in vitro and in vivo studies showed that Ginseng and its active ingredients have beneficial hormone-like role in hormonal *** review thus summarizes the structural similarities between hormones and dammarane ginsenosides and integrates the analogous effect of Ginseng and ginsenosides on prevention and treatment of hormonal disorders published in recent twenty years(1998–2018).The review may provide convenience for anticipate structure-function relationship between saponins structure and hormone-like effect.

关键词： Panax ginseng steroid hormones triterpenoid saponins hormone-like activity molecular signaling

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Emerging trends in early-onset gastric cancer

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Chinese Medical Journal 2024年第18期137卷 2146-2156页

作者： Xinlin Wang Xianchun Gao Jun Yu Xiaotian Zhang Yongzhan Nie State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Xi’anShaanxi 710032China National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032China Beijing Key Laboratory of Carcinogenesis and Translational Research Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

The incidence of early-onset gastric cancer(EOGC)is consistently increasing,and its etiology is notably *** increase may be attributed to distinctive factors that differ from those associated with late-onset gastric cancer(LOGC),including genetic predispositions,dietary factors,gastric microbiota dysbiosis,and screening of high-risk *** factors collectively contribute to the onset of *** significantly differs from LOGC in terms of clinicopathological and molecular ***,multiple differences in prognosis and clinical management also *** study aimed to systematically review the latest research advancements in the epidemiological characteristics,etiological factors,clinicopathological and molecular features,prognosis,and treatment modalities of EOGC.

关键词： Early-onset gastric cancer Epidemiology Etiology Clinicopathological features molecular signaling Prognosis Clinical management

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Natural products and hepatocellular carcinoma:a review

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Hepatoma Research 2015年第1期1卷 119-124页

作者： Asma M.Alnajjar Hussien A.Elsiesy College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Liver and Small Bowel Transplantation and Hepatobiliary and Pancreatic Surgery King Faisal Specialist Hospital and Research CenterRiyadh 11211Saudi Arabia

Hepatocellular carcinoma(HCC)is the fi fth commonest cause of malignancy and the third cause of cancer *** are different treatment options for HCC ranging from loco-regional therapy to surgical *** regimen of systemic chemotherapy has been tried with a poor *** studies aimed at discovering more molecules for the management of *** studies aimed at recognizing and targeting several signaling and molecular pathways that lead to cellular proliferation and tumor *** this review,we discussed the role of several agents found in natural and dietary products such as curcumin,resveratrol,fl avonoids,Rubus aleaefolius Poir total alkaloids,Livistona chinensis seed,and *** had used the names of the above-mentioned products as key words in addition to“HCC”on PubMed to fi nd studies that discussed their roles in *** were downloaded for reviewing and discussing natural products that had adequate studies in treating HCC.

关键词： Hepatocellular carcinoma molecular signaling natural products

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