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System approaches reveal the molecular networks involved in neural stem cell differentiation

Protein & Cell 2012年第3期3卷 213-224页

作者： Kai Wang Haifeng Wang Jiao Wang Yuqiong Xie Jun Chen Huang Yan Zengrong Liu Tieqiao Wen Laboratory of molecular Neurobiology School of Life SciencesShanghai UniversityShanghai 200444China School of Communication and Information Engineering Shanghai UniversityShanghai 200444China College of Life Science Wuhan UniversityWuhan 430072China College of Chemical Engineering and Technology Wuhan University of Science and TechnologyWuhan 430081China Institute of Systems Biology Shanghai UniversityShanghai 200444China􀀍

The self-renewal and multipotent potentials in neural stem cells(NSCs)maintain the normal physiological functions of central nervous system(CNS).The ab-normal differentiation of NSCs would lead to CNS ***,the mechanisms of how NSCs differentiate into astrocytes,oligodendrocytes(OLs)and neurons are still unclear,which is mainly due to the complexity of differentiation processes and the limita-tion of the cell separation *** this study,we modeled the dynamics of neural cell interactions in a systemic approach by mining the high-throughput genomic and proteomic data,and identified 8615 genes that are involved in various biological processes and functions with significant changes during the differentiation processes.A total of 1559 genes are specifically expressed in neural cells,in which 242 genes are NSC specific,215 are astrocyte specific,551 are OL specific,and 563 are neuron *** addition,we proposed 57 transcriptional regulators specifically expressed in NSCs may play essential roles in the development *** findings provide more comprehensive analysis for better understanding the endogenous mechanisms of NSC fate determination.

关键词： neural stem cell cell differentiation mo-lecular networks

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