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THE SHOCK WAVES FOR A mixed-type SYSTEM FROM CHEMOTAXIS

Acta Mathematica Scientia 2023年第4期43卷 1717-1734页

作者：何芬王振陈停停 Center for Mathematical Sciences and Department of Mathematics Wuhan University of TechnologyWuhan 430070China School of Mathematics and Physics China University of GeosciencesWuhan 430074China

In this paper,we study the shock waves for a mixed-type system from *** are concerned with the jump conditions for the left state which is located in the elliptical region and the right state in the hyperbolic *** the generalized entropy conditions,we find that there are different shock wave structures for different *** guarantee the uniqueness of the solutions,we obtain the admissible shock waves which satisfy the generalized entropy condition in both ***,we construct the Riemann solutions in some solvable regions.

关键词： mixed-type shock waves entropy condition chemotaxis conservation laws

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Differential analysis of lymph node metastasis in histological mixed-type early gastric carcinoma in the mucosa and submucosa

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World Journal of Gastroenterology 2018年第1期24卷 87-95页

作者： Qian Zhong Qi Sun Gui-fang Xu Xiu-Qin Fan Yuan-Yuan Xu Fei Liu Shi-Yi Song Chun-Yan Peng Lei Wang Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical School Department of Pathology the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM To investigate the relationship between histological mixed-type of early gastric cancer(EGC) in the mucosa and submucosa and lymph node metastasis(LNM).METHODS This study included 298 patients who underwent gastrectomy for EGC between 2005 and 2012. Enrolled lesions were divided into groups of pure differentiated(pure D), pure undifferentiated(pure U), and mixed-type according to the proportion of the differentiated and undifferentiated components observed under a microscope. We reviewed the clinicopathological features, including age, sex, location, size, gross type, lymphovascular invasion, ulceration, and LNM, among the three groups. furthermore, we evaluated the predictors of LNM in the mucosa-confined *** Of the 298 patients, 165(55.4%) had mucosa-confined EGC and 133(44.6%) had submucosa-invasive EGC. Only 13(7.9%) cases of mucosa-confined EGC and 30(22.6%) cases of submucosa-invasive EGC were observed to have LNM. The submucosal invasion(OR = 4.58, 95%CI: 1.23-16.97, P = 0.023), pure U type(OR = 4.97, 95%CI: 1.21-20.39, P = 0.026), and mixedtype(OR = 5.84, 95%CI: 1.05-32.61, P = 0.044) were independent risk factors for LNM in EGC. The rate of LNM in mucosa-confined EGC was higher in the mixedtype group(P = 0.012) and pure U group(P = 0.010) than in the pure D group, but no significant difference was found between the mixed-type group and pure U group(P = 0.739). Similarly, the rate of LNM in the submucosa-invasive EGC was higher in the mixedtype(P = 0.012) and pure U group(P = 0.009) than in the pure D group but was not significantly different between the mixed-type and pure U group(P = 0.375). Multivariate logistic analysis showed that only female sex(OR = 5.83, 95%CI: 1.64-20.70, P = 0.028) and presence of lymphovascular invasion(OR = 13.18, 95%CI: 1.39-125.30, P = 0.020) were independent risk factors for LNM in mucosa-confined EGC, while histological type was not an independent risk factor for LNM in mucosa-confined EGC(P = 0.106).CONCLUSION fo

关键词： early gastric carcinoma mixed-type lymph node metastasis mucosa lymphovascular invasion

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Histological mixed-type as an independent prognostic factor in stageⅠgastric carcinoma

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World Journal of Gastroenterology 2015年第2期21卷 549-555页

作者： Shuhei Komatsu Daisuke Ichikawa Mahito Miyamae Hiroki Shimizu Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Surgical Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric ***: We analyzed 446 patients who underwent curative gastrectomy for stageⅠgastric cancer between 1999 and 2009. The patients were divided into two groups: those with differentiated or undifferentiated cancer(non-mixed-type, n = 333) and those with a mixture of differentiated and undifferentiated cancers(mixed-type, n = 113).RESULTS: The overall prevalence of mixed-type gastric cancer was 25.3%(113/446). Compared with patients with non-mixed-type gastric cancer, those with mixedtype gastric cancer tended to be older at onset(P = 0.1252) and have a higher incidence of lymph node metastasis(P = 0.1476). They also had significantly larger tumors(P mixedtype gastric cancer(P = 0.0026). Furthermore, mixedtype gastric cancer was independently associated with a worse outcome in multivariate analysis [P = 0.0300, hazard ratio = 11.4(1.265-102.7)].CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stageⅠgastric cancer.

关键词： mixed-type gastric cancer Histological type Progno

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Computational simulations integrating inhibition kinetics of tyrosinase by oxalic acid

Computational simulations integrating inhibition kinetics of...

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第十届全国酶学学术讨论会

作者：严莉朴龙斗周海梦浙江清华长三角研究院浙江省应用酶学重点实验室

Tyrosinase inhibition studies are important for agricultural and medicinal *** predictions and enzymatic assays via kinetics may be used to detect effective inhibitors of *** predicted the 3D structure of tyrosinase from Agaricus bisporus,used a docking algorithm to simulate binding between tyrosinase and oxalic acid(OA),and studied the reversible inhibition oftyrosinase by *** were successful(binding energies for Dock6.3=-18.76 and AutoDock4.2=-2.47 kcal/mol),suggesting that

关键词： tyrosinase oxalic acid docking simulation inhibition kinetics mixed-type carboxyl group

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