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Deep sclerectomy-trabeculectomy with mitomycin c in treating glaucoma:postoperative long-term results

International Journal of Ophthalmology(English edition) 2022年第12期15卷 1951-1959页

作者： chung Shen chean Li Jiang Gayathri Kanchana Niroshani Pati Arambage Punithawathy Ranjit Ophthalmology Department Royal Stoke University HospitalNewcastle RoadStoke-on-Trent ST46QGUnited Kingdom

AIM:To determine the long-term postoperative outcomes of deep sclerectomy-trabeculectomy(DST)with mitomycin c(MMc)in the treatment of ***:Patients who underwent DST with MMc between 2010 and 2017 were included in this retrospective observational *** success was defined as postoperative intraocular pressure(IOP)≤21 mm Hg or 30%reduction of IOP from baseline without any topical IOP-lowering agent,and qualified success defined as IOP≤21 mm Hg or 30%reduction of IOP from baseline with/without single topical *** evaluated the surgical success rates and complication rates of this procedure,as well as described the IOP profiles,best corrected visual acuity(BcVA)profiles and mean deviations(MD)of Humphrey visual field(HVF)24-2 performance at each follow-up time *** linear regression models were constructed to determine estimated predictive values of demographic data,use of topical IOPlowering agents,baseline and postoperative IOP and optical profiles(e.g.,BcVA and MD).RESULTS:Totally 98 eyes(mean postoperative followup 67.5mo)showed mean IOP reduction at every followup *** median BcVA and MD of visual fields were maintained throughout the follow-up intervals when comparing to *** number of IOP-lowering medications decreased from 2.8±0.8 to 0.3±0.7(P=0.068).Totally 84(85.7%)eyes achieved complete success at final *** hyphaema and transient choroidal effusion developed in 15 eyes(15.3%)and 11 eyes(11.2%)*** complications included shallow anterior chamber in 5 eyes(5.1%),bleb leak in 4 eyes(4.1%),bleb revision in 7 eyes(7.1%),bleb needling in 9 eyes(9.2%)and repeat trabeculectomy in 1 eye(1.0%).There was no endophthalmitis,blebitis or macular *** was no significant correlation between postoperative IOP control and postoperative ***:DST with MMc demonstrates effective and sustained long-term outcomes in the treatment of glaucoma with no major complication.

关键词： glaucoma surgical outcome deep sclerectomy trabeculectomy mitomycin c

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Bare sclera resection followed by mitomycin c and/or autograft limbus conjunctiva in the surgery for pterygium:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 1067-1073页

作者： Tan Long Zhi Li Department of Ophthalmology Xi'an No.1 Hospital Department of Ophthalmology Xiangyang Central Hospital

AIM: To evaluate the recurrence and complications after bare sclera resection (BSR) combined with mitomycin c (MMc) treatment and/or autograft limbus conjunctiva (ALc) in the surgery for pterygium. METHODS: Meta -analysis was used to evaluate the differences in patient outcomes between BSR of pterygium with or without MMc and/or ALc. All included studies were randomized trials of patients with pterygium who received BSR followed by MMc and/or ALc in the surgery. The recurrence of pterygium and other complications resulting from different treatments were extracted for analysis. RESULTS: Thirteen studies met the inclusion criteria. The recurrence of pterygium with intraoperative (10) MMc was higher than that with ALc (OR=2.38,95% confidence interval 1.45-3.91, I-2=29%). Postoperative MMc resulted in an incidence of recurrence similar to that of ALc (OR= 0.66, 95% confidence interval 0.30-1.42, I-2=0%), and 10 MMc treatment in combination with ALc produced similar patient outcomes to ALc alone (OR =0.41, 95% confidence interval 0.16-1.01, I-2=16%). Other complications such as punctate epitheliopathy, scleral thinning and ischemia, irritation and persistent epithelium defect, were more common in patients in the MMc group as compared to those treated with ALc. cONcLUSION: The recurrence of pterygium with BSR followed by ALc is lower than that of BSR followed by MMc, and the incidence of other complications is lower. While ALc is a more effective strategy for treating pterygium, the quality of the ALc transplant should be considered when the patient has a history of glaucoma.

关键词： pterygium mitomycin c conjunctiva autogaft

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Posterior scleral application of a mitomycin c-soaked sponge during trabeculectomy

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1071-1077页

作者： Kun Hu Yun-He Song Feng-Bin Lin Ying-Zhe Zhang Ling Jin Meng-Yin Liang Robert N.Weinreb Xiu-Lan Zhang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina Hamilton Glaucoma center Shiley Eye InstituteViterbi Family Department of OphthalmologyUC San DiegoLa JollaCA 92093USA

AIM:To evaluate the safety and efficacy of posterior scleral application(a modified technique)of an antimetabolite mitomycin c-soaked sponge in trabeculectomy for patients with ***:This retrospective study included 101 patients(115 eyes)with glaucoma(aged 12–83y)who underwent trabeculectomy using a modified mitomycin c-soaked sponge placement method.A piece of 3.5×10 mm2 sponge was placed vertically and posteriorly with the long side perpendicular to the *** mitomycin c concentration and exposure time were 0.2–0.5 mg/m L and 1–5min,*** pressure,bestcorrected visual acuity,and hypotensive medications were recorded at baseline and at the final ***,interventions required,and bleb morphology were recorded *** primary outcome was trabeculectomy safety,including complications and bleb morphology;the secondary outcome was the trabeculectomy success ***:At the final follow-up[median 28mo,range 7–67mo and interquartile range(IQR)13mo],the qualified(cumulative)success rate was 93.0%and the complete success rate was 60.0%.No bleb-related complications were *** mean height,extent,and vascularity grades were 0.6±0.9,1.1±0.4,and 2.4±0.9,*** Seidel tests were *** mean posteriority grade was 0.8±***:Trabeculectomy with the long side of a mitomycin c-soaked sponge placed perpendicular to the corneal limbus is safe and effective.

关键词： glaucoma mitomycin c posterior scleral application trabeculectomy bleb morphology

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Safety and efficacy of photodynamic therapy using BcEcF-AM compared to mitomycin c in controlling post-operative fibrosis in a rabbit model of subscleral trabeculectomy

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 348-356页

作者： Azza Mohamed Ahmed Said Rania Gamal Eldin Zaki Thanaa Helmy Mohamed Manal Ibraheem Salman Department of Ophthalmology Faculty of Medicine Ain Shams University Cairo 11361 Egypt Department of Pathology Faculty of Medicine Ain Shams University Cairo 11361 Egypt

AIM： To evaluate the safety and efficacy of cellular photoablation using BcEcF-AM [2, T-bis-（2-carboxyethyl） -5-（and-6）-carboxyfluorescein, acetoxymethyl ester mixed isomersl as a method to control postoperative fibrosis in subscleral trabeculectomy （SST） compared to mitomycin c （MMc） in a rabbit model. METHODS： A comparative prospective case-control animal study was conducted. Fourteen rabbits were subjected to SST with intraoperaUve use of wound modulating agents （MMc or BcEcF-AM） of the right eye （study groups I and II respectively） and SST without use of intraoperative wound modulating agents for the left eye （control group II）. Two rabbits 4 eyes were considered as control group I with no surgical intervention. BcEcF-AM was injected subconjunctivally 30min before surgery followed by intraoperative illumination with diffuse blue light for 10min. Antifibrotic efficacy was established by clinical response and histological examination. clinical response was assessed by measuring intraocular pressure （lOP） at day 1, 3, 5, 7, 14, 21 postoperatively, Success was defined by 〉20.0% reduction in lOP from the preoperative values without anti-glaucoma medications. RESULTS： The mean percentage of reduction was 35.0% in the study group I with only one eye （14.3%） had 12.5% reduction. The mean percentage of reduction was 28.0% in the study group U with two eyes （28.6%） in study group II had 14.2% reduction each. Regarding the control group II, the mean percentage of reduction was 14.3% with 64.3% eyes had 〈20.0% reduction. There was a highly statistically significant difference between each of the study groups （right eyes） and the corresponding control group II （left eyes） as regards the mean postoperative lOP values started from day 5 in both study groups and this highly significant difference remained so till the end of the follow up period. Histologically, MMc treated blebs showed thinning of conjunctival epithelium with marked reduction of the goblet cells relative to con

关键词： subscleral trabeculectomy mitomycin c photodynamic therapy BcEcF-AM intraocular pressure cellular photoablation

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PRE-EXPOSURE OF MIcE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUcES cHROMOSOME ABERRATIONS INDUcED BY SUBSEQUENT EXPOSURE TO HIGH DOSE OF RADIATION OR mitomycin c

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chinese Medical Sciences Journal 1995年第1期10卷 50-53页

作者：于文儒王明东蔡露金玉珂 InstituteofRadiationMedicine CAMS＆PUMCTianjin300192 InstituteofRadlationMedicine NormanBethtmeUniver-sityofMedicalSciencesChangchun130021

The phenomenon of cytogenetic adaptive and cross-adaptive response induced by low dose irradiation and chemical mutagen in mice is described. We found, firstly, that adaptation can be induced by acute low dose Xirradiation (0-100 mGy). Secondly, a cross-adaptation can occur between X-irradiation and mitomycin c (MMc). And finally, mice pre-exposed to chronic low dose rate￣(60)co-Gamma irradiation (0-226.0 mGy/day) are less susceptible to chromosome aberration induced by subsequent acute higher Xirradiation. Therefore, our data suggest that radioadaptive response depends on dose, dose rate and time interval. Possible mechanisms are also discussed.

关键词： radioadaptive response chromosome aberration mitomycin c

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Reduction of mitomycin c resistance in human bladder cancer T24 cells by knocking-down ras oncogene

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cancer Drug Resistance 2018年第1期1卷 59-71页

作者： Osama Sharaf Eldin Abdel-Motaal Fouda Amany R.Youssef Peter Hamilton Perry Maxwell Kate E.Williamson Weston General Hospital Weston-super-Mare BS234TQUK Faculty of Medicine Mansoura UniversityMansoura 35516Egypt centre for cancer Research and cell Biology Queen's UniversityBelfast BT97AEUK

Aim:mitomycin c(MMc)is a commonly used as intravesical treatment for superficial bladder ***,its role in combination with ras inhibition has not been *** aim of this study was to explore the role of ras in MMc-induced apoptosis in T24 bladder cancer cells and to determine the efficacy of combination therapy in ***:We measured the effects of various doses of MMc on apoptosis induction as well as on ras,ERK and Ki-67 protein expression by T24 cell line using immunocytochemistry,flow cytometry and Western *** also tested the effect of siRNA on ras employed singly or in combination with ***:T24 cells expressed high level of ras *** treatment increased the level of ras and ERK protein expression after 24 h,and decreased these levels after 72 *** siRNA(100 nmol/L)caused massive apoptosis associated with a marked decrease in ras expression in T24 *** combined with low doses of MMc,ras siRNA(50 nmol/L)sensitized T24 cells to apoptosis and decreased their expression of *** effect of combined therapy was higher than that of either compound used *** levels of ERK,a downstream target of ras,declined following combination ***:Ras siRNA in combination with low dose MMc is a possible treatment strategy for patients with ras-positive bladder tumors.

关键词： mitomycin c ras oncogene T24 cells bladder cancer siRNA

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Phase Ⅱ study of mitomycin c and cisplatin in heavily pretreated advanced breast cancer

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The chinese-German Journal of clinical Oncology 2006年第6期5卷 442-445页

作者： Xichun Hu Haiyi Guo Xinmin Zhao Zhonghua Wang Xinmiao Yang Xiangjin Liu Jin Li Department of Medical Oncology Fudan University Cancer Hospital Shanghai 200032 China

Objective： The mitomycin c and cisplatin combination was investigated in patients with advanced breast cancer who had been exposed to anthracyclines, vinorelbine and taxanes. Methods： Three-weekly regimen consisted of mitomycin, 6 mg/m^2 administered intravenously on day 1, and cisplatin, 25 mg/m^2 intravenously on day 1-3. Results： Thirty-eight patients aged 25-75 years （median, 46 years） were treated with an overall response rate of 31.6%. The median time to progression （TTP） was 4.0 months. Median TTP for 12 patients with a complete or partial response was 9.0 months, while stable disease and progression of disease 4.0 months, P=0.002. Grade 3/4 side effects of neutropenia, thrombocytopenia and nausea/vomiting were documented in 4 （10.5%）, 4 （10.5%） and 3 （7.9%） patients, respectively. The median overall survival was 13＊ months. conclusion： Mitomydn c/cisplatin doublet showed antitumor activity for anthracydine-, vinorelbine- and taxane-resistant breast cancer comparable to other regimens. This well-tolerated regimen provides an affordable option for patients in china.

关键词： mitomycin c cisplatin phase II study breast cancer

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Smac/DIABLO Promotes mitomycin c-induced Apoptosis of Bladder cancer T24 cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第3期26卷 317-318,328页

作者：汪良曾甫清郑丽端童强松 Department of Urology Department of pathology. Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

The enhancing effects of Smac gene on the mitomycin c-induced apoptosis of the bladder cancer cell line T24 were investigated. The Smac gene was transfected into bladder cancer cell line T24 under the induction of liposome. The intrinsic Smac level was detected by using immunohistochemistry and RT-PcR. The in vitro cellular growth activities were assayed by MTT colorimetry. Apoptosis was assayed by the flow cytometry. The results showed that as compared with the control cells, the apoptosis rate of T24 cells induced by mitomycin c was enhanced by transfected Smac gene. Flow cytometry revealed that, the apoptosis rate was 18.84 % and 33.52 %, and 10.72 % and 26.24 % respectively in blank and transfected cells treated with 0.05 or 0. 005 mg/mL mitomycin c （P〈0.05）. It was concluded that Smac could enhance the apoptosis of T24 by mitomycin c, which could provide a useful experimental evidence for bladder cancer therapy.

关键词： Smac gene bladder cancer mitomycin c apoptosis

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A Study in vitro on the Synergetic cytocidal Effect ofAscorbic Acid and mitomycin c against the Ehrlich As-cites Tumor cells in culture

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Journal of chinese Pharmaceutical Sciences 1995年第3期4卷 118-124页

作者：闵熙李泮海庞贻慧北京同仁医院药剂科北京医科大学药学院物理化学教研室

The synergetic cytocidal effect of ascorbic acid and mitomycin c on Ehrlich as-cites tumor cells in culture was studied. The chain scission of DNA by cu(Ⅱ)mitomycin c/ascorbic acid system,and the chemical kinetics of the cu(Ⅱ) catalyzed aerobic oxidation of ascorbic acid in the presence of mitomycin c were also discussed. Experimental results showed that ascorbic acid and mitomycin c were synergetic in destroying Ehrlich ascites tumor *** effect is related to the breaking action of the cu(Ⅱ)mitomycin c/ascorbic acid system on the DNA chain, and to the quantity of the system produced ·OH, and the speed of production which are both directly proportional to the concentration of ascorbic *** results imply that the ·OH produced in the aerobic oxidation of ascorbic acid,and·OH induced scission of DNA chain, are important factors to he synergetic cytocidal effect of ascorbic acid and mitomycin c on Ehrlich ascites tumor cells.

关键词： Ascorbic acid mitomycin c Ehrlich ascites tumor cells chain scission of

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Studies on mitomycin c Dextran-microspheres

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Journal of chinese Pharmaceutical Sciences 1992年第1期1卷 33-40页

作者：魏树礼孙贻春张敬石谭惟薇谢敬霞李选朱建纲北京医科大学药学院北京医科大学第三医院北京100083

In this paper,the preparation and properties of mitomycin c dextran-microspheres(MMc-DMS)were *** characteristics of pharmacokinetics and embolization effects of MMc-DMS in vivo were studied in *** average diameter of the microspheres was 75±19μm and the content was 5% of *** in vitro experiment, the release rate of drug demonstrated that the microspheres had sustained-release properties. The microspheres and conventional MMc were infused into the hepatic artery of dogs through a catheter for embolization,*** plasma concentration of MMc was de- termined by *** showed that the peak concentration of conventional MMc was 2.6 times as much as *** revealed that peripheral blood vessels de- creased obviously in *** histopathologic examination showed that the microspheres lodged in the hepatic artery and displayed nodular necrosis in the embolized *** MMc-DMS were used in clinical trial in 100 patients with hepatic *** tumor reduc- tion and improvement of symptoms in patients were observed after hepatic arterial *** survival duration was *** showed that the MMc-DMS is a promising embolic agent for treatment of hepatic *** could aid in the use of intensive chemotherapy with minimum systemic side effect.

关键词： mitomycin c mitomycin c dextran-microspheres Hepatic arterial embolization Hepatic cancer

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