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Protective Effect of Pyrroloquinoline Quinone on TNF-α-induced mitochondrial injury in Chondrocytes

Current Medical Science 2021年第1期41卷 100-107页

作者： Guang-tao HAN Wei-song CAI Yu-biao ZHANG Si-qi ZHOU Bin HE Hao-huan LI Department of Orthopedics Renmin Hospital of Wuhan UniversityWuhan430060China

Osteoarthritis(OA)is a degenerative disease characterized by matrix degradation and cell death leading to a gradual loss of articular cartilage *** a bacterial synthesis of quinine,pyrroloquinoline quinone(PQQ)is a strong redox cofactor with a variety of biological benefits,including antioxidant,anti-inflammation-induced mitochondrial metabolism *** study was designed to investigate the effect of PQQ on TNF-α-induced mitochondrial damage in *** isolated from C57BL/6 mice were exposed to TNF-α50 ng/mL,TNF-α50 ng/mL+PQQ 10µmol/L for 24 ***,morphological study,functional study and mechanism study were *** results revealed TNF-α-induced chondrocyte mitochondrion damage could be reduced by application of PQQ,evidenced by elevated number of mitochondria,well-kept mtDNA integrity,preserved ATP level,reestablished mitochondrial membrane potential,and prevented mitochondrial *** present work strongly suggests that the mitochondrion is an important target for OA chondrocyte damage induced by TNF-αand the PQQ protection from this damage ameliorates mitochondrial dysfunction induced by TNF-α.PQQ might be a potential chemical for OA intervention.

关键词： pyrroloquinoline quinone mitochondrial injury osteoarthritis TNF-α chondrocyte

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mitochondrial components transferred by MSC-derived exosomes promoted bone regeneration under high salt microenvironment via DRP1/Wnt signaling

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Nano Research 2024年第9期17卷 8301-8315页

作者： Yiming Wang Shuai Lin Liujing Chen Mingzhao Li Zilu Zhu Zimeng Zhuang Meilian Cai Han Zhang Chenyang Xing Weiran Li Ruili Yang Department of Orthodontics School and Hospital of StomatologyPeking UniversityBeijing 100081China National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China Beijing Key Laboratory of Digital Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China

Bone homeostasis relies on the dynamic balance of osteoblast mediated bone construction and osteoclast-based bone resorption processes,which has been reported to be controlled by various mineral ***,there is no direct evidence of the effect and the underlying mechanism of high salt stimulation on bone *** this study,we demonstrated that high salt stimulation promoted excessive mitochondrial fission mediated by dynamin-related protein 1 in mesenchymal stem cells,which resulted in impaired mitochondrial morphology and ***,this impairment hindered the bone formation of mesenchymal stem cells,resulting in osteopenia in ***,the impaired property of mesenchymal stem cells which was caused by high salt was controlled by dynamin-related protein 1 mediated mitochondrial fission,which inhibited the classical Wnt signaling ***,the osteogenic property of mesenchymal stem cells decreased by high salt could be restored by exosomes to transfer the mitochondrial DNA into the impaired mesenchymal stem *** study provides not only new strategies for promoting bone regeneration but also new insights into the effect and mechanism of exosome-mediated delivery.

关键词： high salt dynamin-related protein 1 mitochondrial injury exosomes bone regeneration

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