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Quantitative mitochondrial proteomics Study on Protective Mechanism of Grape Seed Proanthocyanidin Extracts Against Ischemia/Reperfusion Heart Injury in Rat

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Chemical Research in Chinese Universities 2012年第6期28卷 1035-1040页

作者： LU Wei-da QIU Jie ZHAO Gai-xia QIE Liang-yi WEI Xin-bing GAO Hai-qing Key Laboratory of Cardiovascular proteomics of Shandong Province Department of Geriatrics Qilu Hospital of Shandong University Institute of Pharmacology School of Medicine Shandong University Jinan 250012 P. R. China

Cardiac ischemia/reperfusion（I/R） injury is a critical condition,often associated with high morbidity and *** cardioprotective effect of grape seed proanthocyanidin extracts（GSPE） against oxidant injury during I/R has been described in previous ***,the underlying molecular mechanisms have not been fully *** study investigated the effect of GSPE on reperfusion arrhythmias especially ventricular tachycardia（VT） and ventricular fibrillation（VF）,the lactic acid accumulation and the ultrastructure of ischemic cardiomyocytes as well as the global changes of mitochondria proteins in in vivo rat heart model against I/R *** significantly reduced the incidence of VF and VT,lessened the lactic acid accumulation and attenuated the ultrastructure *** differential proteins related to cardiac protection were revealed by isobaric tag for relative and absolute quantitation（iTRAQ） *** proteins were mainly involved in energy ***,monoamine oxidase A（MAOA） was also *** differential expression of several proteins was validated by Western *** study offered important information on the mechanism of GSPE treatment in ischemic heart disease.

关键词： Grape seed proanthocyanidin extracts(GSPE) Ischemia-reperfusion heart injury In vivo rat model mitochondria proteomics Energy metabolism

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mitochondria in the pathogenesis of diabetes:a proteomic view

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Protein & Cell 2012年第9期3卷 648-660页

作者： Xiulan Chen Shasha Wei Fuquan Yang Key Laboratory of Protein and Peptide Pharmaceuticals and Laboratory of proteomics Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100149China

Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia due to absolute or relative lack of *** great efforts have been made to investigate the pathogenesis of diabetes,the underlying mechanism behind the development of diabetes and its complications remains *** evidence has linked mitochondrial modification to the pathogenesis of diabetes and its complications and they are also observed in various tissues affected by *** is an attractive tool for the study of diabetes since it allows researchers to compare normal and diabetic samples by identifying and quantifying the differentially expressed proteins in tissues,cells or *** progress has already been made in mitochondrial proteomics to elucidate the role of mitochondria in the pathogenesis of diabetes and its *** studies on the changes of mitochondrial protein specifically post-translational modifications during the diabetic state using proteomic tools,would provide more information to better understand diabetes.

关键词： mitochondria proteomics T1DM T2DM diabetes complication

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