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minimum core genome Sequence Typing of Brucella From China

Infectious Microbes & Diseases 2023年第1期5卷 29-35页

作者： Na Zhao Buyun Cui National Institute of Hospital Administration National Health CommissionBeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesState Key Laboratory for Infectious Disease Prevention and ControlBeijingChina

The Gram-negative bacterial genus Brucella includes six classic species based on host specificity,pathogenicity and phenotypic *** more Brucella species were identified in *** many Brucella genomes have been sequenced,genome sequences and analysis of Brucella strains isolated in China are still *** efficient genome-based Brucella typing method is also *** this study,we used the minimum core genome(MCG)typing method to identify and type Brucella *** Brucella isolates fromChinawere newly *** genome sequences of 55 representative Brucella strainswere *** the 75 genomes,1089 genes and 52,030 single nucleotide polymorphisms(SNPs)shared by all isolates were considered as the MCG genes and MCG *** these 52,030 MCG SNPs,Brucella was divided into six MCG *** addition,average nucleotide identity(ANI)values and the distributions of 184 virulence genes were all *** proportions of virulence genes were 90.96%,93.56%,95.89%,86.04%,85.78%and 91.87%for MCG groups 1 to 6,*** intragroup ANI values were higher than the intergroup values,further confirming the validity of the MCG taxonomy *** melitensis and Brucella abortus,the two main Brucella species pathogenic to humans,were well separated from other *** the development and cost reduction of next-generation sequencing,theMCG typing method can be used for rapid identification of Brucella,which can contribute to the rapid diagnosis of brucellosis and ensure timely and effective treatment.

关键词： Brucella minimum core genome sequence typing

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