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Fine mapping quantitative trait loci affecting milk production traits on bovine chromosome 6 in a Chinese Holstein population

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Journal of Genetics and Genomics 2009年第11期36卷 653-660页

作者： Gui Mei 1,Cengceng Yin 1,Xiangdong Ding,Qin Zhang State Key Laboratory for Agrobiotechnology,Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China College of Animal Science and Technology China Agricultural University State Key Laboratory for Agrobiotechnology Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture Beijing 100193

To fine map the previously detected quantitative trait loci （QTLs） affecting milk production traits on bovine chromosome 6 （BTA6）, 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS690 to BM4528 were selected and 918 daughters of 8 sires were genotyped. Two mapping approaches, haplotype sharing based LD mapping and single marker regression mapping, were used to analyze the data. Both approaches revealed a quantitative trait locus （QTL） with significant effects on milk yield, fat yield and protein yield located in the segment flanked by markers BMS483 and MNB209, which spans a genetic distance of 0.6 cM and a physical distance of 1.5 Mb. In addition, the single marker regression mapping also revealed a QTL affecting fat percentage and protein percentage at marker DIK2291. Our fine mapping work will facilitate the cloning of candidate genes underlying the QTLs for milk production traits.

关键词： fine mapping QTL Bos Taurus autosome 6 milk production traits

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A post-GWAS replication study confirming the association of C14H8orf33 gene with milk production traits in dairy cattle

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Frontiers of Agricultural Science and Engineering 2014年第4期1卷 321-330页

作者： Shaohua YANG Chao QI Yan XIE Xiaogang CUI Yahui GAO Jianping JIANG Li JIANG Shengli ZHANG Qin ZHANG Dongxiao SUN Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture National Engineering Laboratory of Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated with one or multiple milk production traits in the Chinese Holstein *** these,38 significant SNPs detected with high confidence by both L1-TDT and MMRA methods were selected to further mine potential key genes affecting milk yield and milk *** blasting the flanking sequences of these 38 SNPs with the bovine genome sequence combined with comparative genomics analysis,26 genes were found to contain or be near to such *** them,the C14H8orf33 gene is merely 87 bp away from the significant SNP,***,we report herein genotype-phenotype associations to further validate the genetic effects of the C14H8orf33 *** pooled DNA sequencing of 14 unrelated Holstein sires,a total of 18 with seven novel SNPs were *** them,nine SNPs were in the 5′regulatory region,one in exon 6 and the other in the 3′UTR and 3′regulatory region.A total of nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for association with five milk production traits in an independent resource *** results showed that these SNPs were statistically significant for more than two traits[Pmilk yield and milk composition traits and may be applied in Chinese Holstein breeding programs.

关键词： GWAS functional annotation Chinese Holstein milk production traits C14H8orf33 gene single nucleotide polymorphisms association study

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Identification of SNPs in Bovine SLC27A1 Gene and Its Effects on milk production traits in Chinese Holstein Cattle

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Agricultural Science & Technology 2010年第6期11卷 106-111页

作者：吕延飞魏彩虹张莉路国彬刘开东陆健孙丹张世芳柳楠杜立新青岛农业大学动物科技学院山东青岛266109 中国农业科学院北京畜牧兽医研究所国家畜禽分子遗传育种中心北京100193 扬州大学动物科学与技术学院江苏扬州225009 辽宁师范大学生命科学院辽宁大连116029

[Objective] This study discussed the SNPs of SLC27A1 gene and its relationship with milk production traits in Chinese Holstein Cattle in order to find the SNP site which had significant effect on milk production traits in Chinese Holstein Cattle.[Method] DNA was extracted from the bleed of 48 Chinese Holstein Cattle selected according to phenotypic character and mixed into DNA pool for SNPs detection by polymerase chain reaction-single strand conformation polymorphism（PCR-SSCP）and cloning *** different genotypes were detected in other 231 Chinese Holstein Cattle by *** association between genotype and production traits was assessed by GLM procedure,SAS version 8.02.[Result] There were T112C in exon3 and G64A loci in 3＇UTR,among them the T112C in exon3 was synonymous *** were 3 genotypes TT,TC and CC in T112C locus and 3 genotypes GG,GA and AA in G64A *** population was at Hardy-Weinberg *** with genotype CC had significantly highest milk yield than those with genotype TC（P0.01）,and there were no significant differences among the 3 genotypes on milk protein percent and milk fat percent（P0.05）,but the tendency of CC TC TT on milk protein percent and the tendency of TT TC CC on milk fat percent were *** was no significant difference among the 3 genotypes of G64A loci on milk yield,milk protein percent and milk fat percent（P0.05）,but the tendency of GA GG AA on milk yield and the tendency of AA GG GA both on milk protein percent and milk fat percent were showed.[Conclusion] There was certain relation between the T112C locus and milk yield traits;It may improve milk yield to raise the frequency of genotype CC;SLC27A1 gene could be a useful candidate gene in selection program on milk yield traits in Chinese Holstein Cattle,which provided a theoretical basis for the marker-assisted breeding and further study of SLC27A1 gene.

关键词： SLC27A1 gene SNPs PCR-SSCP PCR-RFLP milk production traits

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The Effect of PHF20, CYHR1, LOC514211, MAN1A1, Spatc1 Gene Mutation on milk and Reproduction traits in Dairy Cows

The Effect of PHF20, CYHR1, LOC514211, MAN1A1, Spatc1 Gene M...

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作者：阿育（AYU SEPTI ANGGRAENI）华中农业大学

学位级别：硕士

The objective of this study were to identify and confirm the SNP associated with milk production and reproduction, whose SNP were selected from Chinese and British dairy cows based on 60k SNP-Chip. The research was conducted in laboratory of animal genetics, breeding and reproduction in Huazhong Agricultural University, Wuhan City, Hubei Province, People's Republic of China, starts on March 2010-December 2012.470 head Dairy Cows and 35 head water buffaloes have been used in this research, DNA was extracted from the blood samples, PCR-RFLP has been applied to genotype these samples. Analysis of Variance (ANOVA) has done using the General Linear Model (GLM) procedure from SAS 9.13. A value of Pmilk yield (305 DM, Total milk Yield), milk quality (fat percentage, protein percentage, Total milk Yield fat, Total milk Yield protein) and reproduction traits (DFS, AOC, BW, DO and CI).Five SNPs were identified from five candidate genes. SNPs from five candidate gene in cows were polymorphic in dairy cow, whereas in Buffalo were non-polymorphic.4 of SNPs located on PHF20, CYHR1, LOC514211 and SPATC1 were in Hardy-Weinberg disequilibrium, while one SNP located on MAN1 A1 was in Hardy-Weinberg *** SNPs from five candidate gene were identified. SNPs genotypes of five candidate gene PHF20, CYHR1, LOC514211, MAN1A1 and SPATC1 had significant difference in milk reproduction and reproduction traits on Dairy Cow. The mutations of five candidate genes results in significant changes of milk production and reproduction traits in dairy cows. The results indicated that TT genotype of PHF20, A A and GG genotype of CYHR1, TC and TT genotype of LOC514211, AC genotype of MAN1A1 and also AG genotype of SPATC1 candidate gene ware potential marker on both milk production and reproduction traits. There are similar results found in previous

关键词： SNPs PHF20 CYHR1 LOC514211 MAN1A1 SPATC1 milk production traits reproduction traits mutation effect

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Genetic Analysis of Linear Type traits of Holstein Cows in Wuhan

Genetic Analysis of Linear Type Traits of Holstein Cows in W...

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中国畜牧兽医学会第七届养牛学分会2009年学术研讨会

作者： Liu Songbai,Yi Jianming~* (Huazhong Agricultural University,College of Animal Sciences and Technology,Key Laboratory of Agricultural Animal Genetics,Breeding and Reproduction,Ministry of Education,Wuhan 430070)

＜正＞The objectives of this study were to estimate phenotypic and genetic parameters for 25 linear type traits and the relationships between some conformation traits and milk production traits by applying single trait and multiple traits animal models through MTDFREML with REML algorithm in Holstein dairy cattle,to provide some valuable information about genetic improvement of type traits of Holstein dairy cattle herd in *** study included linear type data from 971 daughters of 58 sires collected from 2006 to 2007,and milk production data consisted of 18000 records of 971 cows from 2001 to 2007 derived from Wuhu farm in

关键词： dairy cattle linear type traits milk production traits heritability genetic correlation

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