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Combining choice-related activity measurement and electricalperturbation to probe readout of sensory signals

Combining choice-related activity measurement and electrical...

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中国神经科学学会第十二届全国学术会议

作者： Xue-Fei Yu Yong Gu Institute of Neuroscience and Key Laboratory of Primate Neurobiology Chinese Academy of Sciences

One frequently applied method for associating neural activity with the animal’s perceptual choice is to identify choice realted signals in sensory cortices. In particular, choice related signals describe how neuronal responses covary with perceptual choices on a trial by trial basis. It also quantifies how much an ideal observer can predict the upcoming choice totally based on the preceding responses. Choice related signals so far have been identified among many sensory areas, and have been used as a tool for probing readout. However, this traditional view has now received increasingly arguments as in numerous theoretical works, yet experimental evidence is still missing. In the current study, we combined choice related activity measurement and electrical perturbation technique to probe readout of visual motion signals from multiple sensory cortical areas including MST, MT and VIP. We identified two groups of cells with roughly equal proportion: sensory-choice congruent cells（SCCC） in which choice signals are congruent with respect to the sensory preference, and sensory-choice opposite cells（SCOC） in which choice signals are incongruent with the sensory preference. We found that in areas of MST and MT, microstimulating SCCC generated effects on the animal’s behavioral choice that were consistent with the choice-related signals. In contrast, stimulating SCOC generated effects opposite to the choice-related signals. Based on these experimental results, we proposed two points that could underlie this phenomenon. First, SCOC is correlated with SCCC in a way that is unexpected from the normal noise-signal correlation structure. Second, the readout weight of SCOC should be degraded compared to SCCC. To test this, we constructed a feed-forward network model that implemented the above two conditions. We showed that the model reproduced data pattern similar to that seen in the neurophysiological experiment. Finally, our work also showed that although choice related signals i

关键词： sensory decoding choice related signals noise correlation microstimulation macaque

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A bi-directional neural interface system for use in deep brain stimulation

A bi-directional neural interface system for use in deep bra...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Man-Zhao HAO~1,Xiao-Xing XING~2,Ling-Feng CHEN~2,Ping SHI~1,Guo-Xing WANG~2,Ning LAN~(1,*) 1 Institue of Rehabilitation Engineering,Med-X Research Institute,School of Biomedical Engineering,Shanghai Jiao Tong University 2 School of Microelectronics,Shanghai Jiao Tong University

＜正＞With the development of neuroscience,engineering and computing,the possibilities of interpreting brain activities and restoring functions for various disabilities seem *** recording of the cortical activity with electrophysiological signals provides complementary information about the neural *** passive recording provides useful data,active electrical microstimulation is required in further research and applications. Electrical microstimulation could serve as artificial input to the neural network or serve to modulate neural activity, particularly in the relief of Parkinsonian symptoms by deep brain stimulation（DBS） of subthalamic *** are developing a bi-directional neural interface system mat combines recording and stimulation in one *** with multiple channels can be designed with various geometrical shapes for placement in different locations,regions and layers in the *** recording hardware is composed of a recording headstage,which amplifies signals from the microprobe,a recording interface board is capable of further signal amplifying and filtering.A data acquisition card is connected to the system *** stimulation hardware contains a stimulation interface board,which generates micro current/voltage.A stimulation headstage is used to generate stimulation patterns by switching *** software of the system controller consists of graphical user interface（GUI）,algorithms of signal processing and stimulation patterns *** channel capacity of this system can be expanded as *** makes recording high frequency neural activity *** activity of individual neurons and local field potentials in the vicinity of the probe can be *** recording technique is designed with the highest spatial *** potential applications of this bidirectional system are *** a research tool,we will use it to provide stimulus to subthalamic nucleus and record the neural act

关键词： recording microstimulation neuromodulation deep brain stimulation cerebo-basal ganglia-thalamus system motor control

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