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Preparation of PLGA Ceftiofur Hydrochlorate Lung- targeted microsphere with Spray Drying Process

Journal of Wuhan University of Technology(Materials Science) 2013年第6期28卷 1242-1245页

作者： HAO Zhihui Laboratory of Chemical and Biological College of Chemistry and PharmacyQingdao Agricultural University

To explore the preparation of PLGA ceftiofur hydrochlorate lung-targeted microsphere with spray drying process, the preparation technics was optimized by orthogonal experiments. Appearance, particle size, drug-loaded properties and medicine dissolution rate of the microsphere were evaluated. The experimental results show that the prepared PLGA microspheres loaded with ceftiofur hydrochlorate have good appearance, good encapsulate rate and dissolution. The drug loading capacity of ceftiofur-hydrochlorate-loaded PLGA microsphere prepared with spray drying process is 23.06%, i e, when the dosing ratio is 1：3, the encapsulate rate is 92.23% at maximum, and the release percentage of medicine is at 0.5 h. The medicine is released almost completely at 20 h and the accumulated medicine release is 98.12%.

关键词： PLGA cefliofm- hydrochlorate microsphere lung targeting microsphere morphology

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Preparation of Lung Targeting microspheres of Gelatin Ceftiofur Alkali

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Journal of Wuhan University of Technology(Materials Science) 2013年第2期28卷 400-405页

作者：郝智慧 ZHAO Yongda 曲宝涵 WU Haoting HAO Lihua DING Zhaopeng YANG Fenfang Laboratory of Chemical and Biological College of Chemistry and Pharmacy Qingdao Agricultural University Qingdao Continent Pharmaceutical Co. Ltd. China Institute of Veterinary Drug Control

Gelatin ceftiofur alkali microsphere was prepared to observe its characteristics and evaluate preservation conditions. The glutaraldehyde was increased and the carboxylic methyl chitosan was added to improve the microsphere. The experimental results show microspheres have a better morphology surface and fairly regular structure with 4% glutaraldehyde. The average particle size is 15.84 gm and particle size distribution is narrow which shows a good uniformity. microsphere size was affected by the stirrer speed, dosing ratio and curing degree. The greater drug loaded is, the better microspheres loading is; but with the increase of drug loading rate, the entrapment efficiency increases first and then decreases. The drug release rate of the microsphere is 24.90% in 0.5 h and 84.90% in 48 h, when CMC-GMs with 4% curing agent is 32.03% in 0.5 h and 88.44% in 48 h. So Gms embedding of ceftiofur alkali are better than CMC-GM. The stability tests show that strong light, high temperature, high humidity have a great influence on the microspheres.

关键词： gelatin ceftiofur alkali microsphere lung targeting microsphere morphology

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