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检索条件"主题词=microsphere embolism"

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microsphere embolism:a window to investigate brain microvascualr damage

Microsphere embolism:a window to investigate brain microvasc...

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浙江省毒理学会第二届学术年会

作者： Mahmood Qaisar Hong-yu Yang Kohji Fukunaga Feng Han Institute of Pharmacology Toxicology and Biochemical PharmaceuticsZhejiang University Department of Pharmacy The First Affiliated HospitalCollege of MedicineZhejiang University Department of Pharmacology Graduate School of Pharmaceutical SciencesTohoku University

Despite the growing knowledge on the causes of multiple brain infarcts,undefined mechanisms and lacking therapeutic drugs remain a major clinical challenge Appropriate animal models are needed to study the pathophysio... 详细信息

关键词： microsphere embolism cerebral ischemia blood-brain barrier multiple cerebral infarcts animal model

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microsphere embolism-induced microglia activation via P2X7-FasL signaling

Microsphere embolism-induced microglia activation via P2X7-F...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Geng-Sheng ZHANG,Rong-Rong TAO,Ying-Mei LU,Ji-Yun HUANG,Yue-Long JI,Mei-Hua LIAO, Jun-Feng ZHU,Xue-Jing SHAO,Huan-Wei WANG,Shen-Quan YAN,Feng HAN~* Institute of Pharmacology,Toxicology and Biochemical Pharmaceutics,Zhejiang University,Hangzhou,China.

Objective Emerging epidemiological and clinical evidence indicates that microglia-induced neurotoxicity may be a factor contributing to the development of ischemia or neurodegeneration in response to pathological signals. The current study focused on the temporal,morphological and biochemical aspects of FasL and its expression during the pathological process of cerebral microemboli in *** characterized a mechanism whereby activated microglia mediate neuronal cell death via P2X purinergic receptors and FasL/Fas signaling in response to *** The intracellular events following microsphere embolism were identified by immunohistochemistry study and Western blot *** role of P2X-FasL signaling was addressed by pharmacological approaches and FasL-deficient(gld/ gld) *** Based on our observations,we predict that the early activation of P2X purinoceptors in microglia results in gradual accumulation of FasL and the subsequent activation of downstream ***,in turn,further exaggerates P2X-mediated microglial activation and triggers a vicious circle of neuronal cell *** findings show that FasL is a necessary component of microglia-induced cell death in vitro and in vivo and introduce a novel apoptotic stimulus that works through a P2X-dependent *** These results highlight the potential of a novel therapeutic neuroprotective approach using pharmacological blockade of sustained microglial activation and the death-inducing ligand.

关键词： microsphere embolism ischemia microglia Fas ligand P2X7 receptor neuronal cell death

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Microglia overactivation facilitate neuronal cell death during cerebral microemboli via P2X7 purinoceptor pathway

Microglia overactivation facilitate neuronal cell death duri...

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中国药理学会第十一次全国学术会议

作者： TAO Rong-rong,HUANG Ji-yun,ZHANG Geng-sheng,LIAO Mei-hua,HAN Feng (Institute of Pharmacology,Toxicology and Biochemical Pharmaceutics,Zhejiang University, Hangzhou 310000,China)

OBJECTIVE The present study was desighed to determine the causative links and precise correlations among microglial activation,the ATP-gated P2X purinergic receptor cation channel,and neuronal degeneration during cerebral ischemic cell *** The male rats were subjected to general anesthesia,after which 1000 non-radioactive microspheres were injected into the left carotid *** ipsilateral hemisphere was dissected out for morphological and biochemical *** The activation of microglia significantly increased in the ischemic brain at acute phase of microsphere embolism.A secondary activation of microglia was observed after 72 h and remained elevated through 168 h after microsphere *** current study also focused on the temporal,morphological and biochemical aspects of FasL and its expression during the pathological process of cerebral microemboli in vivo.A significant number of FasL-expressing cells,which were diffusely labeled with a round morphology,were found restricted to the microembolic region 168 h after ***,enhanced P2X immunoreactivity coincided with increased anti-FasL immunore-activity in same ischemic *** characterized a mechanism whereby activated microglia mediate neuronal cell death via P2X purinergic receptors and FasL/Fas signaling in response to *** animals treated with minocycline(45 mg·kg),less FasL expression and Fluoro-Jade C-positive structures were observed in the ipsilateral brain hemisphere of ischemic *** Based on our observations,we predict that the early activation of P2X purinoceptors in microglia results in gradual accumulation of FasL and the subsequent activation of downstream cell death *** together,these results suggest the potential of a novel therapeutic neuroprotective approach using pharmacological blockade of sustained microglial activation against neurovascular disorders.

关键词： microsphere embolism ischemia microglia Fas ligand P2X7 receptor neuronal cell death

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