检索结果-南通市图书馆

Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography

引用

Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 326-334页

作者： Li Wu Manli Wang Vikramjeet Singh Haiyan Li Zhen Guo Shuangying Gui Peter York Tiqiao Xiao Xianzhen Yin Jiwen Zhang Center for Drug Delivery Systems Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201210China School of Pharmaceutical Sciences Anhui University of Chinese MedicineHefei 230038China Institute of Pharmaceutical Innovation University of BradfordBradfordWest Yorkshire BD7 1DPUnited Kingdom Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204China

This study investigated the formulation mechanism of microspheres via internal surfactant distribution. Eudragit L100 based microspheres loaded with bovine serum albumin were prepared by solid in oil in oil emulsion solvent evaporation method using acetone and liquid paraffin system containing sucrose stearate as a surfactant. The fabricated microspheres were evaluated for encapsulation efficiency, particle size, production yield, and in vitro release characteristics. The internal structures of microspheres were characterized using synchrotron radiation X-ray microcomputed tomography(SR-μCT). The enhanced contrast made the sucrose stearate distinguished from Eudragit to have its three dimensional(3D) distribution. Results indicated that the content and concentration determined the state of sucrose stearate and had significant influences on the release kinetics of protein. The dispersity of sucrose stearate was the primary factor that controlled the structure of the microspheres and further affected the encapsulation efficiency, effective drug loading, as well as in vitro release behavior. In conclusion, the 3D internal distribution of surfactant in microspheres and its effects on protein release behaviors have been revealed for the first time. The highly resolved 3D architecture provides new evidence for the deep understanding of the microsphere formation mechanism.

关键词： Three dimensional Synchrotron radiation X-ray microcomputed tomography Distribution microsphere Sucrose stearate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of poly(lactide-co-glycolide)microspheres and evaluation of pharmacokinetics and tissue distribution of BDMC-PLGA-MS in rats

引用

Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 82-90页

作者： Guozhuan Li Liang Yao Jing Li Xiaoyan Qin Zhen Qiu Weidong Chen Anhui University of Chinese Medicine Hefei First People's Hospital

The aim of the present study was to develop a novel long-acting Poly(lactic-co-glycolic acid)(PLGA)-based microspheres formulation of Bisdemethoxycurcum(BDMC) by emulsionsolvent evaporation method. Meanwhile, the effects of the volume ratio of the dispersed phase and continuous phase, the concentration of PLGA and PVA, the theoretical drug loading and stirring speed were investigated. The mean diameter of the microspheres was 8.5 μm and the size distribution was narrow. The encapsulation efficiency(EE) and drug loading efficiency(DLE) of BDME loaded PLGA microspheres(BDMC-PLGA-MS) was 94.18% and 8.14%,respectively. In an in vitro study of drug release, it can be concluded that the BDMC-PLGAMS exhibited sustained and long-term release properties for 96 h. Stability studies suggested that the microspheres we prepared had a very good stability. Furthermore, the results of an in vivo study indicated that the BDMC-PLGA-MS had sustained release effect and was mainly distributed in the lung tissue, and less distribution in other tissues, which indicated that microspheres could be an effective parenteral carrier for the delivery of BDMC in lung cancer treatment.

关键词： Bisdemethoxycurcumin microsphere Poly (lactic-co-glycolic acid) Solvent evaporation method Pharmacokinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Facile preparation of polybenzoxazine-based carbon microspheres with nitrogen functionalities:effects of mixed solvents on pore structure and supercapacitive performance

引用

Frontiers of Chemical Science and Engineering 2020年第6期14卷 1072-1086页

作者： Uthen Thubsuang Suphawadee Chotirut Apisit Thongnok Archw Promraksa Mudtorlep Nisoa Nicharat Manmuanpom Sujitra Wongkasemjit Thanyalak Chaisuwan School of Engineering and Technology Walailak UniversityNakhon Si Thammarat 80160Thailand School of Science Walailak UniversityNakhon Si TTiammarat 80160Thailand The Petroleum and Petrochemical College Chulalongkom UniversityBangkok 10330Thailand Center of Excellence on Petrochemical and Materials Technology Bangkok 10330Thailand

In this study,polybenzoxazine(PBZ)-based carbon microspheres were prepared via a facile method using a mixture of formaldehyde(F)and dimethylformamide(DMF)as the solvent.The PBZ microspheres were successfully obtained at the F/DMF weight ratios of 0.4 and 0.6.These microspheres exhibited high nitrogen contents after carbonization.The microstructures of all the samples showed an amorphous phase and a partial graphitic phase.The porous carbon with the F/DMF ratio of 0.4 showed significantly higher specific capacitance(275.1 F·g^-1)than the reference carbon(198.9 F·g^-1)at 0.05 A-g This can be attributed to the synergistic electrical double-layer capacitor and pseudo-capacitor behaviors of the porous carbon with the F/DMF ratio of 0.4.The presence of nitrogen/oxygen functionalities induced pseudo-capacitance in the microspheres,and hence increased their total specific capacitance.After activation with CO2,the specific surface area of the carbon microspheres with the F/DMF ratio of 0.4 increased from 349 to 859 m^2•g^-1 and the specific capacitance increased to 424.7 F·g^-1 This value is approximately two times higher than that of the reference carbon.The results indicated that the F/DMF ratio of 0.4 was suitable for preparing carbon microspheres with good supercapacitive performance.The nitrogen/oxygen functionalities and high specific surface area of the microspheres were responsible for their high capacitance.

关键词： PBZ carbon porous materials microsphere supercapacitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A controllable soft-templating approach to synthesize mesoporous carbon microspheres derived from d-xylose via hydrothermal method

引用

Journal of Materials Science & Technology 2020年第3期38卷 183-188页

作者： Jian Su Changqing Fang Mannan Yang Youliang Cheng Zhen Wang Zhigang Huang Caiyin You School of Materials Science and Engineering Xi’an University of TechnologyXi’an710048China Faculty of Printing Packaging Engineering and Digital Media TechnologyXi’an University of TechnologyXi’an710048China School of Mechanical and Precision Instrument Engineering Xi’an University of TechnologyXi’an710048China Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics Beijing Technology and Business UniversityBeijing100048China

Highly dispersed carbon microspheres(CMSs)derived from D-xylose were successfully synthesized under hydrothermal conditions and followed by further carbonization,in which F127 was used as a soft template.As-synthesized products were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),flourier transform infrared spectroscopy(FT-IR),thermal gravimetric(TG)and X-ray diffraction(XRD).The results showed that the morphology and structure of the CMSs prominently depended on the stirring speed during hydrothermal reaction.The resultant CMSs principally had non-porous structure without stirring and had a very smooth surface.When the stirring speed increased to 200 rpm,the synthesized mesoporous carbon microspheres at 220?C for 24 h(CMSs-5)had a uniform size distribution of 1–1.4μm and a specific surface area of 452 m^2/g.Nevertheless,with further increasing to 400 rpm,as-fabricated carbon products were mostly amorphous with a low degree of sphericity.Results demonstrated that the diameter of the products decreased with the increase of stirring speed.Furthermore,the sphericity product yield of CMSs reduced with the increase of stirring speed.XRD result showed that all the obtained samples contained partial graphite phase.In addition,a formation mechanism was proposed that involved polymerization product as the precursors for microsphere formation.The controllable and green strategy may provide a great convenience to study properties and applications of carbon microspheres.

关键词： d-xylose Mesoporous carbon microsphere Soft template Hydrothermal method Stirring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug:halofantrine

引用

Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 253-258页

作者： Anthony A Attama Collins N Igbonekwu Department of Pharmaceutics University of Nigeria

Objective:To formulate and evaluate in vitro,surface-modified solid lipid microspheres containing hal of antrine using lipid matrix formed from goat fat and a phospholipid(P90H). Methods:The model drug,hal of antrine in an increasing concentration of 1%,2%,3%,4% and 5%w/w was incorporated into surface-modified solid lipid microspheres formulated by hot homogenization.Effect of drug concentration on the encapsulation efficiency was studied. The dispersion was evaluated using particle size,particle morphology,pH and encapsulation efficiency.The drug formulation with highest encapsulation efficiency was selected and used for the release studies and compared with the release from a commercial dosage form(Halfan~? 250 mg tablet,Claxo-Smithkline,Mayenne France) using simulated gastric fluid(SGF pH 1.2), simulated intestinal fluid(SIF pH 7.2) and phosphate buffer(pH 6.8) as biorelevant media. Results were analyzed statistically and the level of significance was taken to be Pmicrospheres were produced.The particle size of the dispersion was low(32.48-33.87μm) with minimal particle growth and high encapsulation efficiencies(86.8%-91.0%) after 3 months.The pH of the microspheres dispersion changed appreciably after 3 months.In vitro release result obtained revealed sustained and controlled drug release from the lipid microspheres compared with the tablet dosage form.Conclosions: Formulation of hal of antrine as solid lipid microspheres presents a better alternative to the conventional tablet formulation as the in vitro dissolution of the highly lipophilic hal of antrine was highly improved.

关键词： Solid lipid microsphere Particle size stability Halofan trine Encapsulation efficiency Release studies In vitro evaluation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vesicular Li3V2(PO4)3/C hollow mesoporous microspheres as an efficient cathode material for lithium-ion batteries

引用

Nano Research 2019年第8期12卷 1937-1942页

作者： Hongxia Sun Haoran Du Mengkang Yu Kuangfu Huang Nan Yu Baoyou Geng College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular SolidsMinistry of EducationThe Key Laboratory oj Electrochemical Clean Energy of Anhui Higher Education InstitutesAnhui Normal UniversityNO. 189 South Jiuhua RoadWuhu 241002China

Vesicular lithium vanadium phosphate/carbon hollow mesoporous microspheres were fabricated using a facile polyvinylpyrrolidone-assisted aerosol-spray-assisted method and subsequent heat-treatment. While changing the content of polyvinylpyrrolidone, we found that carbon content was adjustable on the surface of lithium vanadium phosphate. By optimizing the carbon content among the composites, the electrochemical performance can be enhanced significantly. The results of electrochemical performance tests suggested that the samples exhibited good cycle performance and high discharge capability in the voltages between 3.0-4.8 V. The observed excellent electrochemical performances could be attributed to the proper content of carbon coating and the vesicular hollow mesoporous microsphere structure, increasing the transmission rate of lithium ions and reducing the structural change during charging and discharging effectively.

关键词： U3V2(PO4)3 aerosol-spray-assisted approach polyvinylpyrrolidone vesicular hollow microsphere electrochemical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Studies on Monodispersed microspheres of Zinc Sulfide Doped with Mn^(2+)

引用

Chinese Journal of Structural Chemistry 2007年第10期26卷 1139-1144页

作者：俞建长王昌运 College of Materials Science and Engineering Fuzhou University

In this paper, zinc acetate, manganese acetate and thiacetamide are used as raw materials to successfully synthesize monodispersed ZnS：Mn^2＋ microspheres by using hydrothermal method and taking P123 surfactant as a template. The products were characterized by XRD, STEM, FT-IR and N2 adsorption-desorption. And the results show that the diameter of this microsphere is 1.0 μm or so, which is larger than that of ZnS microsphere without Mn^2＋ doping, and it has monodispersion, smooth surface and uniform size, The doping of Mn^2＋ does not obviously change the structure of monodispersed ZnS microsphere. The photoluminescence peak lies in a wide band ranging from 450 to 650 nm, and the microspheres emit orange light; with the increase of Mn^2＋ concentration, fluorescence intensity of ZnS：Mn^2＋ microsphere changes, and when the mole ratio of Mn^2＋：Zn^2＋ is 0.3：1, the fluorescence intensity is the strongest.

关键词： monodisperse microsphere fluorescence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of luminescent polystyrene microspheres via surface-modified route with rare earth(Eu^(3+) and Tb^(3+))complexes linked to 2,2'-bipyridine

引用

Rare Metals 2015年第8期34卷 590-594页

作者： Zhen-Xiong Ma Qi-Tao Zhang Jun-Liang Liu Chang-Hao Yan Ming Zhang Teruhisa Ohno School of Chemistry and Chemical Engineering Yangzhou University Department of Applied Chemistry Faculty of EngineeringKyushu Institute of Technology School of Chemical Engineering Yangzhou Polytechnic Institute

Luminescent polystyrene microspheres were easily fabricated from poly(styrene-co-methacrylic acid)and aqueous RE(III) chloride solution(RE=Eu, Tb) in the presence of 2,20-bipyridine as second ligand. The negative charges of carboxyl groups on the surface of microspheres coordinated with rare earth ions at first, such as complexes covalently linked to 2,20-bipyridine, resulting in strong photoluminescence. Various methods, including transmission electron microscope(TEM), scanning electron microscope(SEM), energy dispersive spectroscopy(EDS),Fourier transform infrared spectroscopy(FT-IR), and fluorescence spectrophotometer, were used to characterize the resultant polystyrene composite microspheres. This work highlights the idea that it is facile to synthesis luminescent microspheres by surface-modified method directly.

关键词： Luminescent Polystyrene Terbium Europium 2,2’-bipyridine microsphere

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of taste-masking on ibuprofen microspheres with selected structure features

引用

Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 174-182页

作者： Wei Qin Yuanzhi He Zhen Guo Liu Zhang Li Wu Xianzhen Yin Shailendra Shakya Abi Maharjan Yan Tang Weifeng Zhu Jiwen Zhang Ministry of Education Jiangxi University of Traditional Chinese Medicine Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Pharmacy Shenyang Pharmaceutical University School of Pharmacy University of Chinese Academy of Sciences

The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by synchrotron radiation X-ray micro-computed tomography(SR-μCT) to establish the relationship between the preparation process and microsphere architectures. It was found that the microstructure and morphology of the microspheres were significantly influenced by preparation processes as the primary factors to determine the release profiles and taste-masking effects. The sphericity of ibuprofen microspheres congealed in citric acid solution was higher than that of other two and its morphology was more regular than that being congealed in air or distilled water, and the contact angles between congealing media and melted ibuprofen in octadecanol and glycerin monostearate well demonstrated the structure differences among microspheres of three processes which controlled the release characteristics of the microspheres. The structure parameters like porosity, sphericity, and radius ratio from quantitative analysis were correlated well with drug release behaviors. The results demonstrated that the exterior morphology and internal structure of microspheres had considerable influences on the drug release behaviors as well as taste-masking effects.

关键词： Ibuprofen microsphere Spray congealing Internal structure Synchrotron radiation X-ray micro-computed tomography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Polysaccharide-based Hydrogel and PLGA microspheres for Sustained P24 Peptide Delivery: An In vitro and In vivo Study Based on Osteogenic Capability

引用

Chemical Research in Chinese Universities 2019年第5期35卷 908-915页

作者： CAI Qing QIAO Chunyan NING Jun DING Xinxin WANG Haoyang ZHOU Yanmin Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School of StomotologyJilin UniversityChangchun 130021P.R.China The First Hospital of Jilin University Changchun 130021P.R.China

A bone morphogenetic protein-2(BMP-2) derived synthetic oligopeptide, S [PO4]KIPKASSVPTELSAISTLYLDDD(P24), has shown great potential for facilitating bone regeneration. However, P24 cannot be directly used onto bone defects, while a continuous sustained delivery of P24 may lead to a better formation of bone tissue. Based on this issue, we have developed a sustained delivery system incorporating P24-loaded poly(lactide-co-glycolide)(PLGA) microspheres and nano-hydroxyapatite(n-HA) into the composite hydrogel. The P24-contained compound material was characterized with NMR, FTIR and SEM to demonstrate the fomiation of compound structure containing P24, PLGA and n-HA. A continuous drug release of P24 was observed for over 60 d that evidently enhanced the efficiency in promoting the proliferation of MC3T3-E1 cells and the secrete of alkaline phosphatase(ALP) in vitro. Moreover, the osteoinduction eflect of the hydrogel system with P24 peptide niicrospheres was demonstrated in vivo and manifested by the result of immunohistochemistry. This novel injectable composite hydrogel is expected to be applied to improving the bone defect treatment in bone tissue engineering.

关键词： BMP-2 derived peptide Hydrogel PLGA microsphere Osteogenesis Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：