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An online identity authentication method for blood smear

Journal of Innovative Optical Health Sciences 2016年第6期9卷 1-11页

作者： Xiaozhen Feng Yiping Cao Kuang Peng Cheng Chen Department of Optical Electronics Sichuan University Chengdu Sichuan 610064P.R.China

Blood smear test is the basic method of blood cytology and is also a standard medical test that can help diagnose various conditions and *** examination is the gold stan-dard to determine pathological changes in blood cell *** the biology and medicine automation trend,blood smears'automated management and analysis is very *** online blood smear automatic microscopic image detection system has been *** includes an online blood smear automatic producing part and a blood smear automatic micro-scopic image detection *** identity authentication is at the core of the *** identifiers printed online always present dot matrix digit code(DMDC)whose stroke is not *** the particularities of DMDC and the complexities of online application environment,an online identity authentication method for blood smear with heterological theory is *** synthesizing the certain regional features according to the heterological theory,high identification accuracy and high speed have been guaranteed with few features *** the experiment,the suficient correct matches bet ween the tube barcode and the identification result verified its feasibility and validity.

关键词： Blood smear digit identification identity authentication feature identification blood smear detection microscopic imaging

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A Leukocyte image fast scanning based on max–min distance clustering

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Journal of Innovative Optical Health Sciences 2016年第6期9卷 50-57页

作者： Yapin Wang Yiping Cao Department of Optical Electronics Sichuan University Chengdu Sichuan 610064 P.R.China

A leukocyte image fast scanning method based on max min distance clustering is *** of the lower proportion and uneven distribution of leukocytes in human peripheral blood,there will not be any leukocyte in lager quantity of the captured images if we directly scan the blood smear along an ordinary zigzag scanning routine with high power(100^(x))*** to the larger field of view of low power(10^(x))objective,the captured low power blood smear images can be used to locate *** of the located positions make up a specific routine,if we scan the blood smear along this routine with high power objective,there will be definitely leukocytes in almost all of the captured *** the number of captured images is still large and some leukocytes may be redundantly captured twice or more,a leukocyte clustering method based on max-min distance clustering is developed to reduce the total number of captured images as well as the number of redundantly captured *** method can improve the scanning eficiency *** experimental results show that the proposed method can shorten scanning time from 8.0-14.0min to 2.54.0 min while extracting 110 nonredundant individual high power leukocyte images.

关键词： Leukocyte image fast scanning scanning routine max-min distance clustering window clustering microscopic imaging image segmentation

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Aggregation-induced emission shining in the biomedical field:From bench to bedside

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Engineered Regeneration 2021年第1期2卷 206-218页

作者： Yishen Liu Qingrong Chen Yidan Sun Luojia Chen Yuncong Yuan Meijia Gu Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationSchool of Pharmaceutical SciencesWuhan UniversityWuhanHubei 430071China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Type Culture Collection Wuhan UniversityWuhanHubei 430072China

Fluorogens with aggregation-induced emission characteristics(AIEgens)have been developed in an unprece-dented manner in the biomedical field over the past decade,which is ascribable to their superior fluorescence quantum yields,photosensitivities,as well as their“turn-on”characteristics in their aggregate *** delib-erately engineering their molecular structures and nanocarriers,the input energies of AIEgens can be channeled into specific forms,thereby enabling bioimaging,phototherapy,and even synergetic ***,multiple targeting strategies have been tailored for nidus and pathogen localization that subsequently guide therapeutic *** review integrates application-oriented design strategies for AIEgens,demonstrating how microscopic imaging,bioimaging,and theranostics can be developed to combat tumors,pathogens,and other diseases,and critically discusses challenges and perspectives for clinical translation.

关键词： Aggregation-induced emission(AIE) Biomedical field microscopic imaging Bioimaging Theranostics

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Recent advances in nonlinear optics for bio‐imaging applications

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Opto-Electronic Advances 2020年第10期3卷 13-30页

作者： Silu Zhang Liwei Liu Sheng Ren Zilin Li Yihua Zhao Zhigang Yang Rui Hu Junle Qu Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518000China

Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research *** many structures in biological tissues exhibit strong nonlinear optical effects,nonlinear optics has been widely applied in biomedical *** in the aspect of bio-imaging,nonlinear optical techniques can provide rapid,label-free and chemically specific imaging of biological samples,which enable the investigation of biological processes and analysis of samples beyond other microscopy *** this review,we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this *** perspective of this field is also presented.

关键词： nonliner optics microscopic imaging bio-imaging label-free chemical specific

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