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Dual-Fuel-Driven Bactericidal micromotor

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Nano-Micro Letters 2016年第2期8卷 157-164页

作者： Ya Ge Mei Liu Limei Liu Yunyu Sun Hui Zhang Bin Dong Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices and Collaborative Innovation Center (CIC) of Suzhou Nano Science and Technology Soochow University

In this paper, we report fabrication of the bimetallic Janus microsphere, a magnesium microsphere with a silver surface coating, through thermal evaporation technique. Because of the Janus structure, this micromotor can be propelled in two different directions by the surface silver or magnesium ‘engine' and hydrogen peroxide or water fuel. In addition, due to the bactericidal property of silver, this autonomous micromotor is capable of killing bacteria in solution. As compared to the static one, the micromotor is able to kill the bacteria at a much faster rate(about nine times of that of the static one),demonstrating the superiority of the motion one. We thus believe that the micromotor shown in the current study is potentially attractive for the environmental hygiene applications.

关键词： micromotor Self-propelling Bacterial killing Janus E.coli

NEW ROD-SHAPED ULTRASONIC micromotor AND ITS DRIVING PRINCIPLE

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Transactions of Nanjing University of Aeronautics and Astronautics 2006年第1期23卷 15-19页

作者：朱华董迎晖马相林赵淳生南京航空航天大学超声电机研究中心合肥工业大学机械与汽车工程学院

A new rod-shaped traveling wave ultrasonic micromotor is developed. In the micromotor, five pieces of piezoelectric ceramics clamped by two metal cylinders are used as its stator. The driving principle of the rodshaped ultrasonic motor is simulated. The stator structure and the position to lay these piezoelectric ceramics are calculated to improve the electro mechanical conversion efficiency. A flexible rotor is designed to reduce the radial slip between the stator and the rotor, and to improve the motor efficiency. The prototype motor and its micror driver are tested. The motor is 9 mm in out-diameter, 15 mm in length and 3.2 g in weight. When the motor operates with the first bending frequency （72 kHz） of the stator, its maximal rotational speed and the torque reach 520 r/rain and 4.5 mN · m. Results show that the motor has good stability. The speed fluctuation is controlled within 3% by the frequency automatic tracking technique.

关键词： ultrasonic motor micro electro mechanical system micromotor actuator

KEY TECHNOLOGY FOR PRACTICAL 1-mm-DIAMETER ELECTROMAGNETIC micromotor

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Journal of Shanghai Jiaotong university(Science) 2000年第2期5卷 94-98页

作者：杨红红张琛 Information Storage Research Center Shanghai Jiaotong Univ.Shanghai 200030China

A 1 mm diameter electromagnetic micromotor was developed as a crux component for MEMS application. The motor has a novel layer structure with a 1 mm diameter rotor in the middle of two stators with the same size. The stator uses multiple layers, slotless and concentrated planar winding. The rotor adopts multipolar permanent magnet with high performance. Ruby bearing is used to prolong operating lifetime of the micromotor. The stator winding, consisting of 6 layer coils, 42 turns, and 9 pairs, is fabricated with microprocessing techniques. The micromotor has long operation lifetime, its running speed is stable and controllable, and rotational direction can be easily reversed. Maximum achieved rotational speed of 18000 r/min with maximum output torque of 1.5 μ N·m has been obtained. This paper presented the key technology for developing this kind of micromotor including the design of structure, magnetic circuit, heat problem, friction improvement, microprocessing techniques, and so on.

关键词： mm diameter electromagnetic micromotor layer structure magnetic circuit heat resistance microprocessing technique Document code:A

Stomatocyte structural color-barcode micromotors for multiplex assays

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National Science Review 2020年第3期7卷 644-651页

作者： Lijun Cai Huan Wang Yunru Yu Feika Bian Yu Wang Keqing Shi Fangfu Ye Yuanjin Zhao Precision Medicine Center Laboratory The First Affiliated Hospital of Wenzhou Medical University Wenzhou Institute University of Chinese Academy of Sciences State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast University Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Artificial micromotors have a demonstrated value in the biomedical area. Attempts to develop this technology tend to impart micromotors with novel functions to improve the values. Herein, we present novel structural color-barcode micromotors for the multiplex assays. We found that, by rapidly extracting solvent and assembling monodispersed nanoparticles in droplets, it could form stomatocyte colloidal crystal clusters, which not only showed striking structural colors and characteristic reflection peaks due to their ordered nanoparticles arrangement, but also provided effective cavities for the integration of functional elements. Thus, the micromotors with catalysts or magnetic elements in their cavities, as well as with the corresponding structural color coding, could be achieved by using the platinum and ferric oxide dispersed pre-gel to fill and duplicate the stomatocyte colloidal crystal clusters. We have demonstrated that the self-movement of these structural color-barcode micromotors could efficiently accelerate the mixing speed of the detection sample and greatly increase the probe–target interactions towards faster and more sensitive single or multiplex detection, and the magnetism of these barcode micromotors enables the flexible collection of the micromotors, which could facilitate the detection processes. These features make the stomatocyte structural color-barcode micromotors ideal for biomedical applications.

关键词： structural color micromotor sensor photonic crystal multiplex assay

Motion-based pH sensing using spindle-like micromotors

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Nano Research 2016年第5期9卷 1310-1318页

作者： Limei Liu Yonggang Dong Yunyu Sun Mei Liu Yajun Su Hui Zhang Bin Dong Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices and Collaborative Innovation Center (CIC) of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China

In this study, we report a spindle-like micromotor. This device, which is fabricated using a one-step electrospinning method, consists of biodegradable polycaprolactone and an anionic surfactant. Intriguingly, not only can the resulting micromotor move autonomously on the surface of water for a long period of time （-40 min） due to the Marangoni effect, but it also exhibits a pH sensing behavior due to variations in the surface tension caused by the release of surfactant under different pH conditions. More interestingly, we reveal that the motion-based pH sensing property is size-dependent, with smaller structures exhibiting a higher sensitivity. In addition, since polycaprolactone is a biode- gradable material, the micromotor described in this study can be easily degraded in solution. Hence, features such as one-step fabrication, motion readout, and biodegradability render this micromotor an attractive candidate for sensing algplications.

关键词： micromotor autonomous movement self-propelling motion-based sensing

Recent progress on the design and fabrication of micromotors and their biomedical applications

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Bio-Design and Manufacturing 2018年第4期1卷 225-236页

作者： Wensen Jiangl Liang Ma Xiaobin Xul School of Materials Science and Engineering Tongji UniversityShanghai 201804China State Key Laboratory of Fluid Power and Mechatronic Systems &School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China

The advancement in the micro-/nanofabrication techniques has greatly facilitated the development of micromotors.A variety of micromotors have been invented with powerful functions,which have attracted a broad range of interests from chemistry, physics,mechanics,biology and *** this paper,we reviewed recent progress in micromotors and highlighted representative *** mechanisms of micromotors by internal and external energy sources were *** described general fabrication strategies of the popular micromotors (wire,tubular,helical and Janus)including bottom-up and top-down *** the application section,we primarily focused on the biological applications,such as biological cargo delivery, biosensing and *** last,we discussed the current challenges and provided future prospects.

关键词： micromotor Nanomotor Electric tweezers Drug delivery Nanorobot Micromachine

Chinese herb pollen derived micromotors as active oral drug delivery system for gastric ulcer treatment

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Bioactive Materials 2024年第2期32卷 28-36页

作者： Lijun Cai Cheng Zhao Xinyue Cao Minhui Lu Ning Li Yuan Luo Yongan Wang Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing100850China Southeast University Shenzhen Research Institute Shenzhen518071China

Considerable efforts have been devoted to treating gastric *** in this field tend to develop drug delivery systems with prolonged gastric retention ***,we develop novel Chinese herb pollen-derived micromotors as active oral drug delivery system for treating gastric *** Chinese herb pollen-derived micromotors are simply produced by asymmetrically sputtering Mg layer onto one side of pollen *** exposed to gastric juice,the Mg layer can react with the hydrogen ions,resulting in intensive generation of hydrogen bubbles to propel the *** from the autonomous motion and unique spiny structure,our micromotors can move actively in the stomach and adhere to the surrounding ***,their special architecture endows the micromotors with salient capacity of drug loading and *** on these features,we have demonstrated that our Chinese herb pollen-derived micromotors could effective deliver berberine hydrochloride and show desirable curative effect on the gastric ulcer model of ***,these Chinese herb pollen-derived micromotors are anticipated to serve as promising oral drug delivery carriers for clinical applications.

关键词： micromotor Chinese herb Pollen Drug delivery Gastric ulcer Wound healing

Designing bioactive micro-/nanomotors for engineered regeneration

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Engineered Regeneration 2021年第1期2卷 109-115页

作者： Lijun Cai Dongyu Xu Hanxu Chen Li Wang Yuanjin Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China

Micro/nanoscale motors(MNMs)have been regarded as promising tools in the field of engineered regeneration due to unique property of autonomous ***,a review on the advancements of MNMs in the area of engineered regeneration is presented,covering aspects from their propulsion mechanisms to their frontiers in engineered regeneration,listing the revolutionary applications in biosensing,medical imaging,drug delivery and tissue ***,challenges and future directions of MNMs are finally discussed on the basis of the achievements.

关键词： micromotor Nanomotor Engineered regeneration Propulsion mechanisms

Multi-try Counter-meshing Gears Discrimination Device Based on MEMS Technology

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Journal of Shanghai Jiaotong university(Science) 2008年第3期13卷 280-284页

作者：李胜勇陈文元张卫平高孝裕肖奇军谈顺毅冯敏华 Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Scienceand Technology Shanghai Jiaotong University

A multi-try counter-meshing gears (CMG) discrimination device based on micro electromechani-cal system (MEMS) technology was designed for some specified information fields. The discrimination device consists of two groups of metal CMG, two pawl/ratchet mechanisms, two driving micromotors and two re-setting micromotors, which make the CMG withdraw by raising the pawls. The energy-coupling element is a photoelectric sensor with a circular plate which is notched. micromotor is fabricated using the ultraviolet LiGA (UV-LiGA) fabrication process and precision mechanical engineering. The discrimination device has the function which can automatically reset, with the correct resetting code, it can be tried another times.

关键词： multi-try counter-meshing gears discrimination device micro electromechanical system (MEMS) micromotor