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DEVELOPMENT OF NEEDLE-BASED microendoscopy FOR FLUORESCENCE MOLECULAR IMAGING OF BREAST TUMOR MODELS

Journal of Innovative Optical Health Sciences 2009年第4期2卷 343-352页

作者： CHAO-WEI CHEN TIFFANY R.BLACKWELL RENEE NAPHAS PAUL T.WINNARD JR VENU RAMAN KRISTINE GLUNDE YU CHEN Fischell Department of Bioengineering and Electrical and Computer Engineering University of Maryland College ParkMD 20742USA In Vivo Cellular and Molecular Imaging Center(ICMIC)Department of Radiology Johns Hopkins University School of Medicine BaltimoreMD 21205USA§yuchen@umd.edu¶kglunde@mri.jhu.edu

Fluorescence molecular imaging enables the visualization of basic molecular processes such as gene expression,enzyme activity,and disease-specific molecular interactions in vivo using targeted contrast agents,and therefore,is being developed for early detection and in situ characterization of breast *** advances in developing near-infrared fluorescent imaging contrast agents have enabled the specific labeling of human breast cancer cells in mouse model *** synergy with contrast agent development,this paper describes a needle-based fluorescence molecular imaging device that has the strong potential to be translated into clinical breast biopsy *** microendoscopy probe is based on a gradient-index(GRIN)lens interfaced with a laser scanning *** of the imaging performance,including the field-of-view,transverse resolution,and focus tracking characteristics were *** MDA-MB-231 breast cancer xenografts stably expressing the tdTomato red fluorescent protein(RFP)were used to detect the tumor cells in this tumor model as a proof of principle *** further development,this technology,in conjunction with the development of clinically applicable,injectable fluorescent molecular imaging agents,promises to perform fluorescence molecular imaging of breast cancers in vivo for breast biopsy guidance.

关键词： Breast cancer fluorescence molecular imaging microendoscopy optical imaging tdTomato fluorescent protein.

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Hybrid multimode - multicore fibre based holographic endoscope for deep-tissue neurophotonics

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Light(Advanced Manufacturing) 2022年第3期3卷 84-92页

作者： Yang Du Sergey Turtaev Ivo T Leite Adrian Lorenz Jens Kobelke Katrin Wondraczek Tomas Cizmar Leibniz Institute of Photonic Technology Albert-Einstein-Straβe 9Jena07745Germany Institute of Scientific Instruments of CAS Kralovopolska 147Brno61264Czechia Institute of Applied Optics Friedrich Schiller University JenaFrobelstieg 107743 JenaGermany

In-vivo microendoscopy in animal models became a groundbreaking technique in neuroscience that rapidly expands our understanding of the *** hair-thin endoscopes based on multimode fibres are now opening up the prospect of ultra-minimally invasive neuroimaging of deeply located brain *** these advancements with methods of functional imaging and optogenetics,as well as extending its applicability to awake and motile animals constitute the most pressing challenges for this *** we demonstrate a novel fibre design capable of both,high-resolution imaging in immobilised animals and bending-resilient optical addressing of neurons in motile *** optimised refractive index profile and the probe structure allowed reaching a spatial resolution of 2μm across a 230μm field of view for the initial layout of the ***,the fibre exhibits negligible cross-talk between individual inner-cores during fibre *** work provides a technological solution for imaging-assisted spatially selective photo-activation and activity monitoring in awake and freely moving animal models.

关键词： Multimode fibre Multicore fibre Fibre-based imaging microendoscopy Endomicroscopy Holographic endoscopy

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MICROENDOSCOPIC SPECTRAL IMAGING AS A TOOL FOR SMALL DUCTUAL DIAGNOSTICS:PRELIMINARY EXPERIENCE

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Journal of Innovative Optical Health Sciences 2012年第3期5卷 64-70页

作者： A.DOUPLIK W.L.LEONG A.M.EASSON S.DONE B.C.WILSON A.SHAHMOON Z.ZALEVSKY Department of Physics Ryerson University 350 Victoria StreetToronto M5B 2K3Canada School of Advanced Optical Technologies(SAOT)Friedrich-Alexander Erlangen-Nuremberg University ErlangenGermany Ontario Cancer Institute University Health Network TorontoCanada Xillix Ltd TorontoCanada Medical Photonics Engineering Group(MPEG)Chair of Photonics Technologies Friedrich-Alexander Erlangen-Nuremberg University ErlangenGermany Department of Surgical Oncology Princess Margaret Hospital University Health Network TorontoCanada Department of Medical Biophysics University of Toronto TorontoCanada Faculty of Engineering Bar-Ilan University Ramat GanIsrael

A technical feasibility of autofluorescence ductoscopy in breast milk ducts as blood vessels phantoms has been assessed as *** tumor can be clearly identified through the milk *** also present the operation principle as well as the preliminary experimental results of a new type of microsize multicorefiber that enables imaging through blood vessel *** of a manipulated microwire through a drilled phantom is presented.

关键词： Cancer margin delineation endoscopy microendoscopy autofluorescence imaging surgical guidance multicorefibers

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Endoscopic imaging:How far are we from real-time histology?

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World Journal of Gastrointestinal Endoscopy 2011年第10期3卷 183-194页

作者： Richa Shukla Wasif M Abidi Rebecca Richards-Kortum Sharmila Anandasabapathy Department of Medicine Mount Sinai School of Medicine Department of Bioengineering Rice University Division of Gastroenterology Mount Sinai School of Medicine

Currently,in gastrointestinal endoscopy there is increasing interest in high resolution endoscopic technologies that can complement high-definition white light endoscopy by providing real-time subcellular imaging of the epithelial *** 'optical biopsy' technologies offer the potential to improve diagnostic accuracy and yield,while facilitating real-time *** many endoscopic techniques have preliminarily shown high accuracy rates,these technologies are still *** review will provide an overview of the most promising high-resolution imaging technologies,including high resolution microendoscopy,optical coherence tomography,endocytoscopy and confocal laser *** review will also discuss the application and current limitations of these technologies for the early detection of neoplasia in Barrett's esophagus,ulcerative colitis and colorectal cancer.

关键词： microendoscopy Confocal laser endoscopy Endocytoscopy High-resolution Optical coherence tomography Barrett’s esophagus Ulcerative colitis Colon cancer

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