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Flexible Polyimide microelectrodes Array for Transcorneal Electrical Stimulation

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Journal of Biomedical Science and Engineering 2015年第8期8卷 544-554页

作者： Luis Nino de-Rivera Fidel W.Pérez-Tovar Jorge Santiago Amaya Félix Gil Carrasco Instituto Politécnico Nacional(IPN México)ESIME UPCMéxicoMéxico Asociación para evitar la ceguera en México I.A.P.Hospital“Luis Sánchez Bulnes”(APEC)MéxicoD.F.México

The relationship between the parameters of Transcorneal Electrical Stimulation (TES) and its neuro-protective effect of TES on axotomised Retinal Ganglion Cells (RGCs) is still unclear. This work discusses the design strategy of a new non conventional TES stimulator, the micro fabrication processes and characterization of an array of MEMS microelectrodes over a flexible polymer layer substrate to stimulate the human cornea. The micro-array of electrodes, over a flexible smooth biocompatible polyimide substrate, fine tunes the curvature of the cornea. This tool can help researchers to define the optimal electric stimulation parameters required in TES.

关键词： microelectrodes Flexible Polymide microelectrodes Transcorneal Electrical stimulation

A three-dimensional hollow graphene fiber microelectrode with shrink-effect-enabled enzyme immobilization for sensor applications

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Science Bulletin 2019年第11期64卷 718-722页

作者： Liwei Chen Xiaoteng Ding Jinfeng Zeng Lejiao Chongbei Wu Yuze Wang Qing Han Liangti Qu Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster ScienceMinistry of Education of ChinaSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China College of Life Sciences. Qingdao University Qingdao 266071China

microelectrodes are a type of electrode with microscopic dimension, and due to their rapid diffusing rates, high electrical current densities and signal-to-noise ratios, they can help improve the detection sensitivity for various analytes [1]. Investigations on the fabrication and the application of microelectrodes are highly relevant. Fiber-type microelectrodes with one-dimensional (ID) microstructures that possess ID diffusion, particularly carbon fiber microelectrodes, have been widely fabricated and used in many different types of sensors due to their low cost, small volume, portability, and good biocompatibility [1,2]. However, poor electrocatalytic activity and low response currents preclude the applications of carbon fiber microelectrodes in sensors.

关键词： microelectrodes three-dimensional hollow sensor applications

Neuronal firing in the ventrolateral thalamus of patients with Parkinson＇s disease differs from that with essential tremor

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Chinese Medical Journal 2010年第6期123卷 695-701页

作者： CHEN Hai ZHUANG Ping MIAO Su-hua YUAN Gao ZHANG Yu-qing LI Jian-yu LI Yong-jie Beijing Institute of Functional Neurosurgery Department of NeurologyXuanwu HospitalCapital Medical UniversityKey Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijing 100053China

Background Although thalamotomy could dramatically improve both parkinsonian resting tremor and essential tremor （ET）, the mechanisms are obviously different. This study aimed to investigate the neuronal activities in the ventrolateral thalamus of Parkinson＇s disease （PD） and ET. Methods Thirty-six patients （PD： 20, ET： 16） were studied. Microelectrode recordings in the ventral oral posterior （Vop）and the ventral intermediate nucleus （Vim） of thalamus was performed on these patients who underwent thalamotomy.Electromyography （EMG） was recorded simultaneously on the contralateral limbs to surgery. Single unit analysis and the interspike intervals （ISIs） were measured for each neuronal type. ISI histogram and auto-correlograms were constructed to estimate the pattern of neuronal firing. Mann-Whitney test and Kruskal-Wallis （K-W） test were used to compare the mean spontaneous firing rate （MSFR） of neurons of PD and ET patients. Results Three hundred and twenty-three neurons were obtained from 20 PD trajectories, including 151 （46.7%） tremor related neuronal activity, 74 neurons （22.9%） with tonic firing, and 98 （30.4%） neurons with irregular discharge. One hundred and eighty-seven neurons were identified from 16 ET trajectories including 46 （24.6%） tremor-related neuronal activity, 77 （41.2%） neurons with tonic firing, and 64 neurons （34.2%） with irregular discharge. The analysis of MSFR of neurons with tonic firing was 26.7 （3.4-68.3） Hz （n=74） and that of neurons with irregular discharge （n=98） was 13.9 （3.0-58.1） Hz in PD; whereas MSFR of neurons with tonic firing （n=77） was 48.8 （19.0-135.5） Hz and that of neurons with irregular discharge （n=64） was 26.3 （8.7-84.7） Hz in ET. There were significant differences in the MSFR of two types of neuron for PD and ET （K-W test, both P〈0.05）. Significant differences in the MSFR of neuron were also obtained from Vop and Vim of PD and ET （16.3 Hz vs. 34.8 Hz, 28.0 Hz vs. 49.9 Hz）（K-W test, both P 〈0.05）, respectively. Conclusion In consistent with recent findings, the decre

关键词： Parkinson disease essential tremor ventrolateral thalamic nucleus microelectrodes

Exocytosis determination of SH-SY5Y single cell stimulated by diff erent stimulants on indium tin oxide (ITO) micro-pore electrode

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BIOCELL 2013年第3期37卷 77-83页

作者： Hui ZHAO Fan ZHANG Ling LI Pingang HE Yuzhi FANG Department of Chemistry East China Normal UniversityShanghaiChina Department of Chemistry Zhoukou Normal UniversityZhoukouChina

The human neuroblastoma SH-SY5Y cell line has been used as a model to study mechanisms of neurotransmitter release.In order to study the mechanism of SH-SY5Y single cell exocytosis stimulated by different stimulants,including high K+,3-(1-nitroso-2-pyrrolidinyl)pyridine and nicotine,a type of indium tin oxide(ITO)micro-pore electrode was used to obtain the corresponding amperometric response time.When the cell is stimulated by 0.1 M K+,almost immediate exocytosis could be detected,due to the rapid depolarization of cell membrane.However,the stimulations with 1 mM nicotine and 3-(1-nitroso-2-pyrrolidinyl)pyridine result in a short delay between stimulation and exocytosis,which can be correlated with the time needed for binding of the stimulant to the nicotinic acetylcholine(ACh)receptor and the induction of post-binding phenomena.Thus,the response time of SH-SY5Y single cell exocytosis is significantly affected by the exocytosis mechanisms.

关键词： amperometric monitoring microelectrodes mechanism response time

State-of-the-art MEMS and microsystem tools for brain research

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Microsystems & Nanoengineering 2017年第1期3卷 439-454页

作者： John P.Seymour Fan Wu Kensall D.Wise Euisik Yoon Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48105USA Diagnostic Biochips Inc.Glen BurnieMD 21061USA Department of Biomedical Engineering University of MichiganAnn ArborMI 48105USA

Mapping brain activity has received growing worldwide interest because it is expected to improve disease treatment and allow for the development of important neuromorphic computational methods.MEMS and microsystems are expected to continue to offer new and exciting solutions to meet the need for high-density,high-fidelity neural interfaces.Herein,the state-of-the-art in recording and stimulation tools for brain research is reviewed,and some of the most significant technology trends shaping the field of neurotechnology are discussed.

关键词： brain research electrophysiology MEMS microelectrodes neural engineering neuroscience optoelectrodes optogenetics

Neuronal firing in the globus pallidus internus and the ventrolateral thalamus related to parkinsonian motor symptoms

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Chinese Medical Journal 2009年第19期122卷 2308-2314页

作者： CHEN Hai ZHUANG Ping ZHANG Yu-qing LI Jian-yu LI Yong-jie Beijing Institute of Functional Neurosurgery Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

Background It has been proposed that parkinsonian motor signs result from hyperactivity in the output nucleus of the basal ganglia, which suppress the motor thalamus and cortical areas. This study aimed to explore the neuronal activity in the globus pallidus internus （GPi） and the ventrolateral thalamic nuclear group （ventral oral posterior/ventral intermediate, Vop/Vim） in patients with Parkinson＇s disease （PD）. Methods Twenty patients with PD who underwent neurosurgery were studied. Microelectrode recording was performed in the GPi （n=10） and the Vop/Vim （n=10） intraoperatively. Electromyography （EMG） contralateral to the surgery was simultaneously performed. Single unit analysis was carried out. The interspike intervals （ISI） and coefficient of variation （CV） of ISI were calculated. Histograms of ISI were constructed. A unified Parkinson＇s disease rating scale （UPDRS） was used to assess the clinical outcome of surgery. Results Three hundred and sixty-three neurons were obtained from 20 trajectories. Of 175 GPi neurons, there were 15.4% with tremor frequency, 69.2% with tonic firing, and 15.4% with irregular discharge. Of 188 thalamic neurons, there were 46.8% with tremor frequency, 22.9% with tonic firing, and 30.3% with irregular discharge. The numbers of three patterns of neuron in GPi and Vop/Vim were significantly different （P 〈0.001）. ISI analysis revealed that mean firing rate of the three patterns of GPi neurons was （80.9±63.9） Hz （n=78）, which was higher than similar neurons with 62.9 Hz in a normal primate. For the Vop/Vim group, ISI revealed that mean firing rate of the three patterns of neurons （n=95） was （23.2±17.1） Hz which was lower than similar neurons with 30 Hz in the motor thalamus of normal primates. UPDRS indicated that the clinical outcome of pallidotomy was （64.3±29.5）%, （83.4±19.1）% and （63.4±36.3）%, and clinical outcome of thalamotomy was （92.2±12.9）%, （68.0±25.2）% and （44.3±7.2）% for tremor, rigidity and bradykinesia, respectively. A significant difference of tremor and rigidity was fo

关键词： Parkinson＇s disease movement disorders globus pallidus thalamus microelectrodes

EffectsofDachengqiDecoction（大承气汤）andRhubarbonCellularElectricalActivityintheSmoothMuscleofGuinea－PigTaeniaColi

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Chinese Journal of Integrative Medicine 1995年第2期1卷 56-58页

作者： Yang Wen-xiu(杨文修) Jin Zheng-gen (金正根) Yu Qi (于琦) Xu Wen-Sheng (许文胜) Ni Hong-yan (倪红艳) Yu Hai-ying (于海鹰) (Biophysics Division , Nankai University , Tianjin ) (300100)Tian Zai-shan ( 田在善) (Tianjin Institute of Acute Abdomen with in Biophysics Division Nankai University Tianjin Tianjin Institute of Acute Abdomen with Integrated Traditional and Western Medicine Tianjin

The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellularelectrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique.DCQ and Rb both improve the depolarization of cell membrane , speed up the burst ot slow wave and spikepotentials (when the drug concentration was 1 % ,P>0. 05 , 10 % or 20 % ,P

关键词： Dachengqi decoction rhubarb smooth muscle microelectrodes intracellular record-ing slow wave potential spike potential