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In vivo observation of cerebral microcirculation after experimental subarachnoid hemorrhage in mice

Neural Regeneration Research 2018年第3期13卷 456-462页

作者： Xiao-mei Yang Xu-hao Chen Jian-fei Lu Chang-man Zhou Jing-yan Han Chun-hua Chen Department of Human Anatomy and Embryology Peking University Health Science Center School of Basic Medical Sciences Peking University Health Science Center Tasly microcirculation Research Center Peking University Health Science Center

Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previous studies primarily used fixed tissue or delayed injury models. Therefore, in the present study, we used in vivo imaging to observe the dynamic changes in cerebral microcirculation after subarachnoid hemorrhage. Subarachnoid hemorrhage was induced by perforation of the bifurcation of the middle cerebral and anterior cerebral arteries in male C57/BL6 mice. The diameter of pial arterioles and venules was measured by in vivo fluorescence microscopy at different time points within 180 minutes after subarachnoid hemorrhage. Cerebral blood flow was examined and leukocyte adhesion/albumin extravasation was determined at different time points before and after subarachnoid hemorrhage. Cerebral pial microcirculation was abnormal and cerebral blood flow was reduced after subarachnoid hemorrhage. Acute vasoconstriction occurred predominantly in the arterioles instead of the venules. A progressive increase in the number of adherent leukocytes in venules and substantial albumin extravasation were observed between 10 and 180 minutes after subarachnoid hemorrhage. These results show that major changes in microcirculation occur in the early stage of subarachnoid hemorrhage. Our findings may promote the development of novel therapeutic strategies for the early treatment of subarachnoid hemorrhage.

关键词： nerve regeneration subarachnoid hemorrhage microcirculation disturbance leukocyte adhesion albumin extravasation cerebral blood flow vasoconstriction early brain injury neural regeneration

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