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microalbuminuria sensitive near-infrared AIE probe for point-of-care evaluating kidney diseases

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Aggregate 2024年第3期5卷 421-428页

作者： Zhirong Zhu Xiaoyan Chen Hongze Liao Li Li Haojian Yang Qi Wang Wei-Hong Zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina Department of Pathology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Research Center for Marine Drugs Department of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Laboratory Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Urinary microalbumin(mALB)serves as an exceptionally sensitive indicator for the early detection of kidney damage,playing a pivotal role in identifying chronic renal failure and kidney lesions in ***,the currentfluores-cent methodologies for point-of-care(POC)diagnosis of mALB in real urine still exhibit suboptimal ***,the development and synthesis of QM-N2,an albumin-activated near-infrared(NIR)aggregation-induced emission(AIE)fluorescent probe,are *** strategic incorporation and positioning of quaternary ammonium salts within the quinoline-malononitrile(QM)scaffold sig-nificantly influence solubility and luminescence ***,the quaternary ammonium salt-free variant,QM-OH,and the quaternary ammonium salt integrated at the donor function group(DFG)site,QM-N1,display limited solubility in aqueous solutions while demonstrating a distinctfluorescence ***,the incorporation of quaternary ammonium salt at the conformational functional group(CFG)site in QM-N2 imparts superior dispersibility in water and reduces the ***,the integration of a well-defined D-π-A struc-ture within QM-N2 enables itself with near-infrared emission,which is crucial for mitigating interference from autofluorescence present in urine *** inter-action with albumin,QM-N2 forms a tight bond with the IIA site of the subdomain of human serum albumin(HSA),inducing alterations in protein configuration and constraining the intrinsic motion offluorescent *** interaction inducesfluorescence,facilitating the sensitive detection of trace ***,QM-N2 is applied for POC testing of mALB using portable equipment,particularly in the diagnosis of mALB-related diseases,notably chronic renal *** positioning underscores its potential as an ideal candidate for self-health measurement at home or in community hospitals.

关键词： AIE-active probe kidney disease microalbuminuria point-of-care testing

In vivo evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria

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Frontiers of Medicine 2014年第4期8卷 471-476页

作者： Xiaoyan Chen Wenxia Xiao Xinchun Li Jianxun He Xiaochun Huang Yuyu Tan Department of Endocrinology First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China Department of Radiology First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China

This work aims to estimate the value of diffusion weighted imaging （DWI） and diffusion tensor imaging （DTI） in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria （NAU） versus microalbuminuria （MAU） prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group （n = 14） or MAU group （n = 16） according to 8 h overnight urinary albuminuria excretion rate （AER） results. A contemporary cohort of health check-up recipients were included as controls （n = 12）. DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient （ADC） and fractional anisotropy （FA） of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm^2, the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls （P 〈 0.01）. The mean ADC in the MAU group [（2.22± 0.07） × 10^-3 mm^2/s] was slightly lower than that of the NAU group [（2.31 ± 0.22） × 10^- 3 mm^2/s], but this difference was not statistically significant （P 〉 0.05）. The FAvalue in the MAU group was higher than that in the control group （0.45 ± 0.07 vs. 0.3±0.03, P = 0.004） but did not differ from that in the NAU group （0.42 ± 0.03）（P 〉 0.05）. ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.

关键词： type 2 diabetes mellitus microalbuminuria diffusion weighted imaging diffusion tensor imaging early-stagekidney injury

Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria

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World Journal of Gastroenterology 2013年第1期19卷 97-102页

作者： Goh Eun Chung Nam Ju Heo Min Jung Park Su Jin Chung Hae Yeon Kang Seung Joo Kang Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM:To investigate the relationship between Helicobacter pylori(***) seropositivity and the presence of ***:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System Gangnam Center for a routine check-up and underwent tests for *** immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were *** study subjects completed a structured questionnaire,anthropometric measurements and laboratory *** immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the *** presence of microalbuminuria was defined as a UACR from 30 to 300 μg/*** presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic *** logistic regression analysis was performed to identify the risk *** dependent variable was microalbuminuria,and the independent variables were the other study ***:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were *** them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with *** with microalbuminuria had a significantly higher *** seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that *** seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL microalbuminuria in diabetic subjects after adjust

关键词： Helicobacter pylori Seropositivity microalbuminuria Atherosclerosis Diabetes

microalbuminuria associated with systolic blood pressure and arterial compliance in Chinese metabolic syndrome patients

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Chinese Medical Journal 2007年第16期120卷 1395-1399页

作者： LI Xin-li XU Qiong LU Xin-zheng ZHANG Hai-feng ZHOU Yan-li CAO Ke-jiang HUANG Jun Department of Cardiology First Aftiliated Hospital of Nanjing Medical University Nanjing 210029 China

Background There is significant evidence showing that microalbuminuria and arterial compliance are sensitive markers for early cardiovascular diseases. However, whether microalbuminuria is associated with reduced arterial compliance in Chinese metabolic syndrome （MS） patients remains unknown. Methods According to the definition of MS proposed by ATPⅢ in 2001, USA, subjects （n=362） were divided into three groups according to the number of risk factors： group 1 （control）, group 2 （medium, 〈 3 risk factors） and group 3 （MS, ≥ 3 risk factors）. Both large artery compliance （C1） and small artery compliance （C2） were measured with the CVProfilor DO-2020 Cardiovascular Profiling System, and microalbuminuria was evaluated with the ratio of albumin to urine creatinine. Results （1） As C1 and C2 levels elasticity decreased, albumin creatinine ratio （ACR） and the prevalence of microalbuminuria increased within those groups with MS risk factors. C1 and C2 were negatively correlated with the ranking of MS risk factors, ACR was positively correlated with the ranking of MS risk factors （all P〈0.05）. （2） Subjects were also categorized into a microalbuminuria group and a normal group, C1 and C2 in the microalbuminuria group were lower than in the normal group. （3） Multivariate regression analysis showed that increased systolic blood pressure （SBP） and reduced arterial compliance were the main risk factors for microalbuminuria in the MS group. Conclusions The risk of developing microalbuminuria was higher in the subjects with multiple metabolic abnormalities. Increased systolic blood pressure and reduced arterial compliance may be the main predictors for microalbuminuria in MS.

关键词： metabolic syndrome microalbuminuria arterial elasticity

Tangled relationship between insulin resistance and microalbuminuria in children with obesity

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World Journal of Clinical Pediatrics 2022年第6期11卷 455-462页

作者： Alberto Maria Colasante Mario Bartiromo Michele Nardolillo Stefano Guarino Pierluigi Marzuillo GiuseppeSalvatore R C Mangoni di S Stefano Emanuele Miraglia del Giudice Anna Di Sessa Department of Woman Childand General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaples 80138Italy

Childhood obesity represents a complex disease with a well-known cardiometabolic burden including fatty liver,type 2 diabetes,metabolic syndrome,and cardiovascular *** a pathogenic point of view,insulin resistance(IR)represents the key factor underlying the spectrum of these obesity *** observed in adults,recent data supported the occurrence of microalbuminuria(MA)as marker of early kidney dysfunction and its potential link with cardiometabolic factors also in children with *** fact,a well-documented pathophysiological hypothesis both in adults and children supported an intimate correlation with the major feature of obesity such as IR through the influence of insulin on renal *** on the clinical and prognostic relevance of this relationship in daily practice(including an increased risk of chronic kidney disease development overtime),more scientific attention needs to be paid to the evaluation of early kidney damage in children with *** this paper,we attempt to address three debated questions regarding the intriguing liaison between IR and MA in children with obesity:(1)What is the prevalence of pediatric MA?(2)What is the state of art of MA in children with obesity?and(3)Is there a link between IR and MA in children with obesity?

关键词： Kidney damage microalbuminuria Insulin resistance Children Obesity

RENAL ENDOGENOUS ET-1 AND URINARY SODIUM EXCRETION AND microalbuminuria IN HUMAN SALT-SENSITIVE HYPERTENSION

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Academic Journal of Xi'an Jiaotong University 2001年第1期13卷 30-32页

作者：朱丹军刘治全刘杰刘昀 Department of Cardiology First Hosp. of Xi'an Jiaotong Univ. Xi'an 710061 China

Objective To investigate the urinary endothelin-1 (ET-l ) excretion and urinary sodium excretion, microalbuminuria and ambulatory blood pressure(ABP) in salt-sensitive(SS) hypertension patients. Methods Twen- ty-one cases of normotensive subjects and 32 cases of uncomplicated hypertensive patients were recruited in this study. Salt sensitivity was determined by acute venous saline loading test. Before saline loading, 24-hour ABP mea- surements were performed. Urine samples were collected to assay ET-1,urinary sodium excretion and urinary albumin excretion(UAF). Results Compared to slat-resistant(SR) subgroup, SS showed low urinary ET-1 excretion in nor- motensive group (P<0.05) or hypertensive group (P<0.01),regardless or saline loading or not. The nighttime MAP of SS was higher than SR subgroup in normotensive or hypertensive group. Urinary sodium excretion during 4h of saline loading was significantly lower in SS than that in SR hypertensive patients (P<0.05). Twenty-four-hour UAE of SS patients was higher than SR group (P<0.01). Results of further correlation analysis indicated that the urinary ET-1 excretion was positively related to urinary sodium content and negatively to ABP and UAE. Conclusion Uri- nary ET-1 is low in SS normotensives or hypertension patients,which may play a role in renal sodium retention and renal impairment or SS hypertension patients.

关键词： salt sensitivity hypertension endothelin-1 microalbuminuria

Significance of intensive glycemic control on early diabetic nephropathy patients with microalbuminuria

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Journal of Pharmaceutical Analysis 2010年第2期22卷 135-138页

作者： Wan-Hong Lu1,Bing-Yin Shi1,Xiao-Tian Zhang2,Dan-Guo Wei3,Wei-Dong Liu4,Pei-Zhen Duan51. the First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710061 2. Department of Human Anatomy and Histology,Medical School of Xi’an Jiaotong University,Xi’an 710061 3. Health Center of Changqing Construction and Engineering Company,Xi’an 710086 4. Hospital of Xi’an University of Architecture and Technology,Xi’an 710055 5. Hospital of Xi’an University of Posts and Telecommunications,Xi’an 710061,China. First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China Department of Human Anatomy and Histology Medical School of Xi'an Jiaotong University Xi'an 710061 China Health Center of Changqing Construction and Engineering Company Xi'an 710086 China Hospital of Xi'an University of Architecture and Technology Xi'an 710055 China Hospital of Xi'an University of Posts and Telecommunications Xi'an 710061 China

Objective To investigate the therapeutic effect of intensive glycemic control on patients with early diabetic nephropathy. Methods A total of 41 type 2 diabetes patients who developed microalbuminuria were divided into two groups randomly. Patients in Group A received intensive glycemic control and the blood glucose in Group B was regularly controlled. Glycemic monitoring and control were followed for 12 weeks to observe the changes of microalbuminuria in both groups; meanwhile the levels of serum lipids and coagulation indices were also recorded. Results The urine albumin excretion rate (UAER) in Group A decreased significantly from (47.91±13.86)mg/24h to (35.31±14.56)mg/24h after 12 weeks (P0.05]. The decrease of triglyceride (TG) and low-density lipoprotein cholesterol (LDL cholesterol),and the increase of high-density lipoprotein cholesterol (HDL cholesterol) showed no significant differences (P>0.05). And the level of plasma fibrinogen (FIB) showed no significant decrease after 12 weeks,either (P>0.05). Conclusion Intensive glycemic control reduces the level of microalbuminuria and may ameliorate the progression of early diabetic nephropathy.

关键词： glycemic control diabetic nephropathy (DN) microalbuminuria

microalbuminuria in White and Black Hypertensive Nondiabetic Brazilian Patients

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World Journal of Cardiovascular Diseases 2014年第5期4卷 236-243页

作者： Andreza Alves Belo Eduardo Luis Guimaraes Machado Amintas Fabiano de Souza Figueiredo Estevao Lanna Figueiredo Centro de Desenvolvimento Inovacao Ciencia e Tecnologia—CDICTBHTECBelo HorizonteMGBrazil Faculdade de Ciencias Medicas de Minas Gerais Belo HorizonteMGBrazil Departamento de Análises Clinicas e Toxicologicas Faculdade de FarmaciaUniversidade Federal de Minas GeraisBelo HorizonteMGBrazil Hospital Lifecenter Belo HorizonteMGBrazil

microalbuminuria (MAU) is a predictor of cardiovascular mortality in patients with diabetes mellitus (DM) and hypertension (HTN) and also in an unselected population. The American Diabetes Association (ADA) and the National Kidney Foundation (NKF) define MAU as an albumin/creatinine ratio (ACR) between 30 and 300 μg/mg in both men and women. Aim: To evaluate the possible relationship among MAU, HTN and gender and ethnicity in Brazilian nondiabetic primary hypertensive patients. Design: Population-based study. Participants: Ninety-eight men and women, seventy-two black and twenty-six white nondiabetic primary hypertensive patients aged 20 years or older were selected. Forty healthy individuals, paired according to age, gender, and ethnics were used as controls. Methods: Early-morning midstream urine was used. Urinary albumin was spectrophotometrically measured with Coomassie Brillant Blue G-250. Creatinine was determined by a method based on Jaffe’s reaction. ACR (μg albumin/mg creatinine) was calculated. Data are expressed as medians. Results: ACR level was significantly higher in 98 hypertensive patients (38.00) than in 40 control individuals (23.00) (P < 0.001). ACR level was significantly higher in 48 hypertensive male (46.00) than in 50 hypertensive female (34.00) (P = 0.008). No significant effect of ethnicity on ACR levels between 26 hypertensive Whites (35.50) and 72 hypertensive Blacks (38.00) was observed (P = 0.978). Conclusions: The ACR level, significantly higher in hypertensive patients than in control individuals, supports data from the literature. To our knowledge, this is the first study demonstrating that the ACR level is significantly higher in men than in women. The lack of an ethnicity effect supports what was already asserted, namely, that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, as estimated by molecular markers.

关键词： Albumin Creatinine Rate microalbuminuria Primary Hypertension Ethnic Groups Brazilian

microalbuminuria and Associated Factors in Diabetics at the CNHU-HKM of Cotonou

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Journal of Diabetes Mellitus 2023年第1期13卷 1-11页

作者： Annelie Kerekou Hode Hubert Dedjan Doucelyne d’Almeida Endocrinology Teaching Unit Faculty of Health Sciences of the University of Abomey-Calavi Abomey-Calavi Benin

Diabetes mellitus is a disease of great frequency and is a major public health problem. Several complications can occur during the course of diabetes such as diabetic nephropathy, which starts with microalbuminuria in diabetic patients. This was a cross-sectional and analytical study which took place from 23 September to 23 December 2021 in the Endocrinology-Metabolism-Nutrition Department of the CNHU-HKM of Cotonou, Benin. We carried out an exhaustive census of the patients. Type 2 diabetic patients were included in the study, and 24-hour microalbumunuria, fundus examination and assessment of complications were performed. We identified 145 type 2 diabetic patients of whom 44 had positive microalbuminuria, i.e. a prevalence of 30.3%. There were 61 men and 84 women with a sex ratio of 0.72. The mean age was 59 years with extremes of 26 and 85 years. The complications identified in diabetics with positive microalbuminuria were Neuropathy (43.2%), Nephropathy (22.7%) and Retinopathy (20.5%). Factors associated with microalbuminuria in diabetics were: age, occupation, hypertension, diabetes imbalance, erectile dysfunction. Conclusion: microalbuminuria is common in type 2 diabetes. It should be managed early to slow the progression of kidney disease to the end stage.

关键词： Diabetes microalbuminuria Associated Factors Benin