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microrna-1224-5p Is a potential prognostic and Therapeutic Biomarker in Glioblastoma:Integrating Bioinformatics and Clinical Analyses

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Current Medical Science 2022年第3期42卷 584-596页

作者： Xing WEI Qing-mei ZHANG Chang LIU Song WU Wei-xia NONG Ying-ying GE Li-na LIN Feng LI Xiao-xun XIE Bin LUO Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning 530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Central Laboratory of pre-Clinical Medicine(Key Laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning 530021China Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Key Laboratory of Early prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China

Objective Glioblastoma(GBM)is the most common,invasive,and malignant primary brain tumor with a poor prognosis and high recurrence ***’s known that some micrornas(miRNAs)which are associated with tumorigenesis and progression can be considered as prognostic and therapeutic targets in tumors including *** study aims to highlight the potential role of the core miRNAs in GBM and their potential use as a prognostic and therapeutic *** Differentially expressed miRNAs(DEmiRNAs)were identified in GBM by integrating miRNA-sequencing results and a GBM microarray dataset from the Gene Expression Omnibus(GEO)database through bioinformatics *** dysregulated miRNAs were identified by survival analysis through Chinese Glioma Genome Atlas(CGGA).Target genes of the dysregulated miRNAs were predicted on MiRWalk and miRTarBase ***2.0 database,Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways analysis were used to analyze the function of the dysregulated ***,protein-protein interaction(ppI)network analysis was used to identify the top 20 hub targets of the up-regulated and down-regulated miRNAs,***,core miRNAs in GBM were identified by constructing dysregulated miRNA-differentially expressed hub gene *** of the core miRNAs expression was detected in 41 GBM tissues compared to 8 normal brain ***,the potential biomarkers were identified by clinical correlation analysis and survival *** Totally,68 intersecting DEmiRNAs were identified,40 of which were upregulated and the other 28 miRNAs were *** upregulated and 4 downregulated miRNAs showed prognostic *** differentially expressed hub genes were regulated by the miR-28-5p and miR-1224-5p,which were respectively upregulated and downregulated in *** correlation between miR-1224-5p level and recurrence was statistically significant(p=0.011).Survival analysis showed that high

关键词： glioblastoma micrornas microrna-1224-5p bioinformatics

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