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Laser Manipulation of micro Untransmissive Particles in Water

Journal of Thermal Science 2009年第1期18卷 85-90页

作者： Masahiro OTA Makoto SHIMODA Yuuki SUSAI Division of Mechanical Engineering Tokyo Metropolitan University

The laser trapping of untransmissive particles are discussed in this paper. Photon can generate the momentum tothe untransmissive particle by diffraction and reflection on the surface of the particles. We tried laser trapping ofuntransmissive particles using an attractive force caused by the diffraction and radiation force caused by *** laser trapping system includes CW YAG laser, which has 1.064 μm in wave length and an optical *** motions of particles were monitored by a CCD camera on the top of the microscope and recordedby PC connected to the CCD camera.

关键词： Laser manipulation Laser trapping Optical tweezers micro manipulation micro sphere

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Preparation and in vitro release studies of thymosin-loaded PLA microspheres

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Journal of Southeast University(English Edition) 2007年第2期23卷 294-297页

作者：何熠肖国民东南大学化学化工学院南京210096

To obtain a kind of convenient oral dosage form of protein, which can be fully absorbed and is efficient and safe, the thymosin-loaded PLA（polylactic acid） microspheres are prepared by the emulsification- solvent evaporation method and the orthogonal design is used to optimize the technology of preparation. The form of the medicament microspheres of thymosin are proved by differential thermal analysis （DTA）. The drug content is determined by the Lowry method, and the package ratio of medicament microspheres of thymosin and drug release in vitro are calculated. The results show that the average diameter and encapsulation efficiency of the product prepared according to the optimized formulation are 13. 8 μm and 80. 7%, respectively. The in vitro release behavior within 12 h can be described by the Higuchi equation with T1/2 = 295 rain. There are no significant changes in size distribution and residual drug contents after being stored at 25℃ and 40 ℃ for 90 d, respectively. Due to the fact that its thymosin content and package ratio meet the requirement, and its releasing half life is long, the thymosin-loaded PLA microsohere has a favorable application future.

关键词： thymosin polylactic acid micro sphere in vitro release

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