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Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

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World Journal of Hepatology 2022年第8期14卷 1562-1575页

作者： Samar Samir Youssef Asmaa Elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz Department of Microbial Biotechnology National Research CentreCairo 1211Egypt Department of Environmental and Occupational Medicine National Research CentreCairo 1211Egypt Department of Endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11562 Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 1256Egypt Theodor Bilharz Research Institute Cairo 1256Egypt

BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common *** expression of microRNAs(mirnas)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different ***,limited information is available regarding their expression in Egyptian HCC *** To assess the role of circulating mirnas-326,miRNA-424,and miRNA-511 in Egyptian HCC *** This prospective observational study included 70 HCC patients and 25 healthy *** circulating levels of these three mirnas were evaluated by real-time *** operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression *** All mirnas were differentially expressed in HCC patients;mirnas326 and miRNA-424 were upregulated,while miRNA-511 was *** miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from ***,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.

关键词： Hepatocellular carcinoma mirnas-326 miRNA-424 miRNA-511 Modified response evaluation criteria in solid tumors

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