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The functional analysis of transiently upregulated mir-101 suggests a “braking” regulatory mechanism during myogenesis

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Science China(Life Sciences) 2021年第10期64卷 1612-1623页

作者： Shurong Liu Shujuan Xie Huafeng Chen bin Li Zhirong Chen Yeya Tan Jianhua Yang Lingling Zheng Zhendong Xiao Qi Zhang Lianghu Qu MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Vaccine Research Institute of Sun Yat-sen University the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Cell-Gene Therapy Translational Medicine Research Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Skeletal muscle differentiation is a highly coordinated process that involves many cellular signaling pathways and microRNAs(mirNAs).A group of muscle-specific mirNAs has been reported to promote myogenesis by suppressing key signaling pathways for cell ***,the functional role and regulatory mechanism of most non-muscle-specific mirNAs with stage-specific changes during differentiation are largely ***,we describe the functional characterization of mir-101a/b,a pair of non-muscle-specific mirNAs that show the largest change among a group of transiently upregulated mirNAs during myogenesis in C2C12 *** overexpression of mir-101a/b inhibits myoblast differentiation by suppressing the p38/MAPK,Interferon Gamma,and Wnt pathways and enhancing the C/EbP ***2a,a key protein in the p38/MAPK pathway,was identified as a direct target of mir-101a/***,we found that the long non-coding RNA(lncRNA)Malat1,which promotes muscle differentiation,interacts with mir-101a/b,and this interaction competes with Mef2a mRNA to relieve the inhibition of the p38/MAPK pathway during *** results uncovered a“braking”role in differentiation of transiently upregulated mirNAs and provided new insights into the competing endogenous RNA(ceRNA)regulatory mechanism in myoblast differentiation and myogenesis.

关键词： mir-101a/b p38/MAPK signaling pathway Mef2a Malat1 skeletal muscle differentiation

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