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MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression

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Chinese Journal of Cancer 2016年第12期35卷 666-672页

作者： Run-Fen Cheng Jian Wang Jing-Yi Zhang Lin Sun Yan-Rui Zhao Zhi-Qiang Qiu Bao-Cun Sun Yan Sun Department of Pathology Tianjin Medical University Cancer Institute and Hospital Department of Pancreatic Oncology Tianjin Medical University Cancer Institute and Hospital Department of Epidemiology and Biostatistics Tianjin Medical University Cancer Institute and Hospital Department of Pathology Tianjin Medical University

Background: MicroRNA?506(mir?506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of mir?506 in pancreatic ductal adenocarcinoma(PDAC) remains unclear. In this study, we aimed to evaluate the phenotype of mir?506 in PDAC.Methods: Using mi RNA in situ hybridization, we examined the expression of mir?506 in 113 PDACs and 87 paired normal pancreatic tissues. We evaluated mi R?506 expression in PDAC cells, normal pancreatic ducts, and acinus/islands, and we analyzed the associations between mir?506 expression and the clinicopathologic characteristics of PDAC patients.Results: mir?506 expression was higher in PDAC than in matched normal pancreatic ductal cells(P 506 than the poorly diferentiated ones(P = 0.023). Moreover, mi R?506 expression was negatively associated with pathologic T category(P = 0.004) and lymph node metastasis(P = 0.033), suggesting that mi R?506 might inhibit the progression of PDAC.Conclusions: Our results suggest that mi R?506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house?keeping, tumor?suppressing mi RNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.

关键词： Pancreatic ductal adenocarcinoma mir?506 Tumor suppressor Development Progression

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