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Cloning and characterization of a mouse liver-specific gene mfrep-1, up-regulated in liver regeneration

Cell Research 2002年第Z2期 353-361页

作者： JUN VAN, HAD YING, FBI GU, JIN HE, Yu Li LI, Hm MIN LIU, YONG HUA XU Laboratory of Molecular and Cellular Oncology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200031, China Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Human fibrinogen-related protein-1/liver fibrinogen-related protein-1 (HFREP-l/LFIRE-1), a liver-specific protein, is a member of fibrinogen superfamily that exerts various biological activities. However, the function of HFREP-l/LFIRE-1 in liver remains unknown. Here we isolated its mouse ortholog gene-mouse fibrinogen-related protein-1 (mfrep-1), which encoded 314 amino acids, exhibiting 80.4% similarity to HFREP-l/LFIRE-1. Northern blot analysis revealed that 1.2-kb mfrep-1 mRNA was detected selectively in mouse liver. To explore the function of mfrep-1, we examined the levels of mfrep-1 mRNA during regeneration after 70% partial hepatectomy (PHx) in mice, mfrep-1 mRNA increased in the regenerating liver and reached the first shoulder peak at 2-4 h after PHx. Cycloheximide pretreatment could suppress the induction of mfrep-1, indicating the up-regulation of this gene need de novo protein synthesis. Its mRNA continued to elevate at 6 h thereafter and reached the second peak at 24 h. The enhanced express

关键词： mfrep-1 in silico cloning liver regeneration liver-specific expression.

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