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The effect of methylseleninic acid on paclitaxel efficacy in A2780 ovarian cancer cells

Journal of Nanjing Medical University 2009年第2期23卷 111-116页

作者： Qiaoli Zhang Rami G. Azrak Maternal and Child Health Center the First Affiliated Hospital of Xi' an Jiaotong University Xi' an 710061 China Department of Cancer Biology Roswell Park Cancer Institute Buffalo New York 14263 U.S.A.

Objective：The role of methylseleninic acid （MSeA）, a selenium compound, has been documented in cancer chemoprevention. However, the therapeutic effect of MSeA in combination with paclitaxel, a chemotherapeutic agent used to treat ovarian cancer, is unknown. In this study, we investigated the effect of combination treatment of MSeA and paclitaxel against ovarian cancer cells. Methods：Ovarian cancer cells（A2780） were treated with different concentrations of MSeA, paclitaxel alone or in combination. The individual and combined concentrations of drugs that achieved certain cells growth/death were determined using a sulforhodamine B（SRB） assay. Drug effects on cell viability were further confirmed using floating cell count and trypan blue exclusion assay. The mean Values ± standard deviation were calculated and compared between treatment groups using unpaired t test. Results： The concentration of paclitaxel alone that inhibited 50% of cell growth（IC50） was 0.5 μmol/L. This concentration increased to 1.2 μmol/L when paclitaxel was given in sequential combination with MSeA. The number of dead cells after the combination treatment did not show a significance increase when compared with drug alone. Conclusion：Pretreatment with MSeA did not enhance the paclitaxel effect against A2780 ovarian cancer cells.

关键词： methylseleninic acid paclitaxel ovarian cancer

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Modulation of histone acetylation in human esophageal squamous cells exposed to methylseleninic acid

Modulation of histone acetylation in human esophageal squamo...

引用

细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Chenfei Hu Wei Zhang Qing Xu Leehuang Chen Kai Ma Mei Liu Hongxia Zhu Jinfeng Bai Lanping Quan Ningzhi Xu Laboratory of Cell and Molecular Biology Cancer Institute & Cancer Hospital Academy of Medical Sciences & Peking Unio Medical College

Selenium is an essential trace element for humans and animals,however,the anti-tumor effects of selenium compounds remain *** this study,we explored the function of selenium in esophageal *** result indicated that methylseleninic acid could induce growth inhibition and apoptosis in esophageal squamous cell carcinoma(ESCC) ***,MSA could induce cell growths inhibition in nude mice xenograft *** treated with MSA,HDAC activity was inhibited in

关键词： Selenium methylseleninic acid Histone deacetylase histone acetyltransferase KLF4 cell growth inhibition

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