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A novel protein complex that regulates active dna demethylation in Arabidopsis

Journal of Integrative Plant Biology 2021年第4期63卷 772-786页

作者： Pan Liu Wen-Feng Nie Xiansong Xiong Yuhua Wang Yuwei Jiang Pei Huang Xueqiang Lin Guochen Qin Huan Huang Qingfeng Niu Jiamu Du Zhaobo Lang Rosa Lozano-Duran Jian-Kang Zhu Shanghai Center for Plant Stress Biology Center of Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Department of Horticulture College of Horticulture and Plant ProtectionYangzhou UniversityYangzhou 225009China Department of Horticulture&Landscape Architecture Purdue UniversityWest LafayetteIndiana 47906USA

Active dna demethylation is critical for altering dna methylation patterns and regulating gene *** 5-methylcytosine dna glycosylase/lyase ROS1 initiates a base-excision repair pathway for active dna demethylation and is required for the prevention of dna hypermethylation at 1000 s of genomic regions in *** ROS1 is regulated and targeted to specific genomic regions is not well ***,we report the discovery of an Arabidopsis protein complex that contains ROS1,regulates ROS1 gene expression,and likely targets the ROS1 protein to specific genomic ***1 physically interacts with a WD40 domain protein(RWD40),which in turn interacts with a methyl-dna binding protein(RMB1)as well as with a zinc finger and homeobox domain protein(RHD1).RMB1 binds to dna that is methylated in any sequence context,and this binding is necessary for its function in ***-of-function mutations in RWD40,RMB1,or RHD1 cause dna hypermethylation at several tested genomic regions independently of the known ROS1 regulator *** the hypermethylated genomic regions include the dna methylation monitoring sequence in the ROS1 promoter,plants mutated in RWD40,RMB1,or RHD1 show increased ROS1 ***,ROS1 binding to the ROS1 promoter requires RWD40,RMB1,and RHD1,suggesting that this complex dictates ROS1 targeting to this *** results demonstrate that ROS1 forms a protein complex with RWD40,RMB1,and RHD1,and that this novel complex regulates active dna demethylation at several endogenous loci in Arabidopsis.

关键词： dna demethylation dna methylation methyl-dna binding ROS1 WD40 domain

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