检索结果-南通市图书馆

Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

引用

Hepatoma Research 2015年第1期1卷 136-146页

作者： Mohamed I.M.Ibrahim Rialet Pieters Sekena H.Abdel-Aziem Anna M.vander Walt Cornelius C.Bezuidenhout John P.Giesy Mosaad A.Abdel-Wahhab Food Toxicology and Contaminants Department National Research CenterDokkiCairo 12622Egypt Unit of Environmental Sciences and Management North-West UniversityPrivate Bag X6001Potchefstroom 2520South Africa Cell Biology Department National Research CenterDokkiCairo 12622Egypt Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSaskatchewan S7N 5B4Canada Department of Zoology and Center for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824USA Department of Biology and Chemistry and State Key Laboratory in Marine Pollution City University of Hong KongKowloonHong KongChina School of Biological Sciences University of Hong KongHong KongChina State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210093JiangsuChina Department of Biology Hong Kong Baptist UniversityHong KongChina

Aim:Protective effects of aqueous extract of Amaranthus hybridus against afl atoxin B1(AFB_(1))and/or fumonisin B1(FB_(1))on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA ***:H4IIE-luc cells were incubated with different concentrations of AFB_(1) and/or FB_(1) for 24 and 48 h with or without aqueous extract of ***:AFB_(1) decreased the viability of cells after 24 and 48 h of ***_(50)values for AFB_(1) were 10.5 and 1.8μmol/L for the two periods,*** the 48 h exposure to mycotoxin repeated with a pre-treatment of 20 and 40μg/mL extract of ***,the EC_(50)changed to 3.88 and 7.67μmol/L,respectively.H4IIE-luc cells exposed to FB_(1) for 24 h responded more than those incubated for 48 *** treated with a combination of AFB_(1) and FB_(1) were less viable with a signifi cant decrease in the greater *** mixture of AFB_(1) and FB_(1) resulted in a signifi cant threat to H4IIE-luc as indicated by the absence or appearance of new bands in random amplifi ed polymorphic DNA analysis,which demonstrated damage to *** protective effects were probably due to greater content of total phenolics,carotenoids,β-carotene,folic-,linolenic-,linoleic and palmitic acids,as well as calcium,magnesium,iron,zinc,and selenium observed in the ***:Exposure to 40μg/mL of extract of *** protected cells from damage to DNA by stabilizing DNA.

关键词： Afl atoxin B1 Amaranthus hybridus cytotoxicity DNA fumonisin B1 hepatoma cells methyl thiazol tetrazolium assay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：