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Preparation and characterization of methacrylated gelatin/bacterial cellulose composite hydrogels for cartilage tissue engineering

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Regenerative Biomaterials 2020年第2期7卷 195-202页

作者： Liling Gu Tao Li Xiongbo Song Xianteng Yang Senlei Li Long Chen Pingju Liu Xiaoyuan Gong Cheng Chen Li Sun Medical College Guizhou UniversityGuiyang 550025China Department of Rehabilitation Guizhou Provincial People’s HospitalGuiyang 550002China Center for Joint Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Orthopedics Guizhou Provincial People’s HospitalGuiyang 550002China Zunyi Traditional Chinese Medicine Hospital Zunyi 563099China

methacrylated gelatin(GelMA)/bacterial cellulose(BC)composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed by *** morphology of GelMA/BC hydrogel was examined by scanning electron microscopy and compared with pure *** hydrogels had very well interconnected porous network structure,and the pore size decreased from 200 to 10 mm with the increase of BC *** composite hydrogels were also characterized by swelling experiment,X-ray diffraction,thermogravimetric analysis,rheology experiment and compressive *** composite hydrogels showed significantly improved mechanical properties compared with pure *** addition,the biocompatility of composite hydrogels were preliminarily evaluated using human articular *** cells encapsulated within the composite hydrogels for 7 days proliferated and maintained the chondrocytic ***,the GelMA/BC composite hydrogels might be useful for cartilage tissue engineering.

关键词： methacrylated gelatin bacterial cellulose hydrogel cartilage tissue engineering

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Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： Yang J. Fatima K. Zhou X. He C. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defects requires superior mechanical strength, a feat that a single hydrogel scaffold cannot achieve. The objective is to seamlessly integrate optimal microarchitecture, mechanical robustness, vascularisation, and osteoinductive biological responses to effectively address these critical load-bearing bone defects. To confront this challenge, three-dimensional (3D) printing technology was employed to prepare a polycaprolactone (PCL)-based integrated scaffold. Within the voids of 3D printed PCL scaffold, a methacrylate gelatin (GelMA)/methacrylated silk fibroin (SFMA) composite hydrogel incorporated with parathyroid hormone (PTH) peptide-loaded mesoporous silica nanoparticles (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/PCL (PM@GS/PCL) scaffold. The feasibility of fabricating this functional scaffold with a customised hierarchical structure was confirmed through meticulous chemical and physical characterisation. Compression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the composite scaffold. Additionally, in vitro angiogenesis potential of PM@GS/ PCL scaffold was evaluated through Transwell and tube formation assays using human umbilical vein endothelium, revealing the superior cell migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenchymal stem cells clearly illustrated robust osteogenic differentiation properties within this scaffold. Furthermore, the bone repair potential of the scaffold was investigated on a rat femoral defect model using micro-computed tomography and histological examination, demonstrating enhanced osteogenic and angiogenic performance. This study presents a promising strategy for fabricating a microenvironment-matched composite scaffold for bone tissue engineering, providing a potential solution for effective bone defect repair. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserve

关键词： angiogenesis bone regeneration methacrylated gelatin methacrylated silk fibroin osteogenesis PTH

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