检索结果-南通市图书馆

Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer

Asian Journal of Andrology 2023年第4期25卷 462-467页

作者： Zhi-Peng Wang Jun-Ru Chen Jin-Ge Zhao Sha Zhu Xing-Ming Zhang Jia-Yu Liang Ben He Yu-Chao Ni Guang-Xi Sun Peng-Fei Shen Hao Zeng Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology The Third People’s Hospital of ChengduChengdu 610031China

To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases inmen with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients betweenNovember 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classifiedinto 5 subgroups according to metastatic patterns as follows: simple bone metastases (G1), concomitant bone and regional lymphnode (LN) metastases (G2), concomitant bone and nonregional LN (NRLN) metastases (G3), lung metastases (G4), and livermetastases (G5). In addition, patients in the G3 group were subclassified as G3a and G3b based on the LN metastatic plane(below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostatecancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showedthat patients in G1 and G2 had relatively favorable clinical outcomes, patients in G3a and G4 had intermediate prognoses, andpatients in G3b and G5 had the worst survival outcomes. We observed that patients in G3b had outcomes comparable to those inG5 but had a significantly worse prognosis than patients in G3a (median CFS: 8.2 months vs 14.3 months, P = 0.015;medianOS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC,and the presence of concomitant bone and NRLN metastases is a valuable prognostic factor. Furthermore, our findings indicatethat the farther the NRLNs are located, the more aggressive the disease is.

关键词： lymph node metastases metastatic hormone-sensitive prostate cancer metastatic pattern metastatic site nonregional lymph node metastases staging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical information and management status of de novo stage IV breast cancer patients: a Chinese multicenter investigation (CSBrS-002)

引用

Chinese Medical Journal 2021年第13期134卷 1569-1575页

作者： Ang Zheng Bao-Liang Guo Jian-Guo Zhang Feng Jin Chinese Society of Breast Surgery Department of Breast Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Department of General Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150081China 不详

Background:Although de novo stage IV breast cancer is so far incurable,it has entered an era of individualized treatment and chronic disease *** on systemic treatment,whether the surgical resection of primary or metastatic foci of de novo stage IV breast cancer can bring survival benefits is currently *** aimed to explore the clinicopathological factors and current status of the management of de novo stage IV breast cancer in China to provide a reference for clinical ***:Based on the assistance of Chinese Society of Breast Surgery,a retrospective study was conducted to analyze the clinical data of patients with de novo stage IV breast cancer in 33 centers from January 2017 to December *** relationship between basic characteristic(age,menstrual status,family history,reproductive history,pathological type,estrogen receptor[ER]status,progesterone receptor[PR]status,human epidermal growth factor receptor 2[HER2]status,Ki-67 percentage,and molecular subtype),and metastasis sites(lung metastasis,liver metastasis,and bone metastasis)was examined by Pearson Chi-square ***:A total of 468 patients with de novo stage IV breast cancer were *** median age of the enrolled patients was 51.5 *** most common pathological type of primary lesion was invasive carcinoma(97.1%).Luminal A,luminal B,HER2 overexpressing,and triple-negative subtypes accounted for 14.3%,51.8%,22.1%,and 11.8% of all cases,***,PR status,and HER2 status were correlated with lung metastasis(χ^(2)=6.576,4.117,and 8.643 and P=0.037,0.043,and 0.003,respectively).Pathological type,ER status,PR status,and molecular subtype were correlated with bone metastasis(χ^(2)=5.117,37.511,5.224,and 11.603 and P=0.024,<0.001,0.022,and 0.009,respectively).Age,PR status,HER2 status,Ki-67 percentage,and molecular subtype were correlated with liver metastasis(χ^(2)=11.153,13.378,10.692,21.206,and 17.684 and P=0.004,<0.001,0.001,<0.001,and 0.001,respect

关键词： De novo stage IV breast cancer metastatic site Systemic therapy Multicenter investigation Chinese Society of Breast Surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of sites versus number of metastases on survival of patients with organ metastasis from newly diagnosed cervical cancer

Impact of sites versus number of metastases on survival of p...

引用

2019年浙江省妇科肿瘤学学术大会

作者： Zhuomin Yin Huarong Tang Li Li Juan N Shuhui Yuan Hanmei Lou Department of Gynecologic Radiation Oncology Zhejiang Cancer Hospital

Objective:The aim of this study was to investigate the potential associations of the sites and the number of specific metastases with survival in patients newly diagnosed with cervical ***:Medical records of patients with organ metastases of newly diagnosed cervical cancer at Zhejiang Cancer Hospital from October 2006 to December 2016 were reviewed *** times were compared using the Kaplan-Meier *** associated with survival were identified using univariate and multivariate Cox proportional hazards ***:A total of 99 patients with newly diagnosed organ metastatic cervical cancer were *** follow-up was 11.6 months(range,0.5-114.7 months).Median overall survival(OS) time was 11.7 months from diagnosis,with 1-,2-,and 5-year OS rates of 48.2%,22.8%,and 12.6%,*** most common site of organ metastasis was bone(36.8%),followed by lung(32.8%) and liver(24%).In univariate analysis,OS rates were better for bone metastasis than visceral metastasis(P=0.013),oligometastasis than non-oligometastasis(P=0.003)and single organ metastasis than multiple organ metastases(P=0.016),while that for liver metastasis was poorer than non-liver metastases(Psite of metastasis is associated with overall survival of patients with newly diagnosed organ metastatic cervical cancer,with liver metastasis signifying particularly poor overall *** treatments should be administered to patients depending on the specific metastatic sites.

关键词： uterine cervical neoplasm survival organ metastasis metastatic site number of metastases

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：