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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Pakming LAU CAS Key Laboratory of Brain Function and Disease School of Life ScienceUniversity of Science and Technology of ChinaHefei 230027China

＜正＞Recent studies indicate that ketamine,a noncompetitive NMDA receptor antagonist,can produce rapid antidepressant effects within hours that sustains for weeks in patients resistant to conventional antidepressants that increase central serotonergic（5-HT） *** ask whether and how ketamine modulates synaptic plasticity in the schaffer-CAl pathway of the hippocampus in rodents that is known to be involved in the pathology of major depressive disorder（MDD）.Using in vivo field potential recordings,we found that metaplasticity at schaffer-CAl pathway of the hippocampus is disrupted in forced swimming model of ***,after ketamine injection,metaplasticity in the same group of animals is restored to the level comparable to nai’ve animals,apparently through mTOR-dependent synaptic ***,the rapid antidepressant action of ketamine may be mediated by restoring metaplasticity at schaffer-CAl pathway of the hippocampus in rodents.

关键词： depression ketamine metaplasticity hippocampus

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NMDA受体NR2A和NR2B亚基在海马CA1区LTP和metaplasticity中作用的研究

NMDA受体NR2A和NR2B亚基在海马CA1区LTP和metaplasticity中作用的...

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作者：廖振华上海交通大学

学位级别：硕士

脑的学习记忆功能和突触可塑性的机制长期以来是神经科学的研究热点,而长时程增强(long-term potentiation, LTP)被认为是研究突触可塑性的最重要的细胞模型。大量证据已经证明LTP的形成必须要有NMDA受体的激活。近年来,关于N-methyl-D-... 详细信息

脑的学习记忆功能和突触可塑性的机制长期以来是神经科学的研究热点,而长时程增强(long-term potentiation, LTP)被认为是研究突触可塑性的最重要的细胞模型。大量证据已经证明LTP的形成必须要有NMDA受体的激活。近年来,关于N-methyl-D-aspartate(NMDA)型谷氨酸受体的NR2A和NR2B亚基在长时程增强的形成中的不同作用有很多相关文献报告,但是其具体作用机制还不清楚。本实验通过电生理学方法在小鼠成年期海马CA1区的神经细胞测试和比较了NR2A及NR2B亚基的选择性阻断剂分别在低频和高频刺激诱发的LTP形成中的作用,发现NR2B的选择性阻断剂虽然可以提高低频刺激诱发LTP的概率,却不能增强高频刺激诱发的LTP的强度;而NR2A的选择性阻断剂对两种刺激所引起的LTP形成均起到抑制作用。以上结果表明NR2B通过提高LTP诱发的阈值对LTP形成起到负向调节作用,而NR2A的激活则是LTP的形成的必要条件。本实验还对NMDA受体NR2B亚基在metaplasticity,即可塑性的可塑性中的作用进行了研究。通过电生理学方法在小鼠成年期海马CA1区的神经细胞测试和比较了在priming刺激后阻断NR2B或NR2A亚基对metaplasticity的影响,发现priming刺激后NR2B的阻断导致了正常情况下无法被诱导的LTP的恢复,从而提示了NR2B亚基为metaplasticity的诱导所必需。

关键词：海马长时程增强 metaplasticity NMDA受体 NR2A NR2B

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The role of NMDA receptor 2B subunits on metaplasticity in hippocampal CA1 neurons

The role of NMDA receptor 2B subunits on metaplasticity in h...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Zhen-Hua LIAO,Qian YANG,Yi-Xin XIAO,Yue ZHANG,Sheng-Tian LI Institute of Nueroscinces,Shanghai Jiao Tong University,Shanghai 200240,China

＜正＞Long-term potentiation（LTP）,one of the major forms of synaptic plasticity,is thought to be an important cellular model for learning and *** has been shown from many experiments that an activation of N-methyl-D-aspartate subtype of glutamate receptors（NMDARs） plays an important role in an induction of LTP at hippocampal CA1 synapse. NMDARs are assembled from NMDAR subunit 1（NR1） and at least one type of ***1 is an essential and basic functional ***2,as contrast,serves as an assistant subunit to lead to the diversity of NMDA *** different subtypes of NR2 subunit,including NR2A,NR2B,NR2C and NR2D,NMDARs vary in their *** adult mice hippocampus,NR2A and NR2B are the predominant NR2 *** once reported by Yu Tian Wang’s group, NR2A is required for an induction of LTP and NR2B for LTD,but many other reports are also available to contradict this *** these results have suggested that the role of NR2A and NR2B on synaptic plasticity is *** 1996, Wickliffe *** and Mark *** brought us a concept of metaplasticity,*** plasticity of *** is shown from the experiments at the hippocampal CAl area that a "Priming" stimulus prior to tetanic stimulus shall change the amplitude of *** duration of "Priming" stimulus may stay for one *** this study we investigated the role of NR2A and NR2B in the induction of metaplasticity in mice hippocampal CA1 *** evidences are provided here that NR2B is involved in the regulation of *** have made further study of its functional mechanism.

关键词： synapse metaplasticity NMDA receptor NR2B LTP

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Electric-Induced Cycloelimination for Simulating Structural Plasticity in Organic Nociceptors

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CCS Chemistry 2024年第6期6卷 1466-1476页

作者： Zhiheng Zhu Kai Liu Haojie Huang Yangshuang Bian Mingcong Qin Chengyu Wang Wei Wen Mingliang Zhu Wenkang Shi Yanwei Liu Zhiyuan Zhao Huijuan Yan Hanlin Wang Yunqi Liu Yunlong Guo Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100190

Continuous lifelong acquisition,updating,and finetuning of knowledge and skills is of crucial significance for the survival of ***,current neuromorphic devices exhibit obvious catastrophic forgetting when restimulated by new *** remains a challenge for neuromorphic devices and artificial intelligence to achieve continuous ***,we propose an electric-induced cycloelimination strategy to realize an organic transistor nociceptor that can simulate synaptic and structural *** system benefits from the ring-opening characteristics of cross-linked poly(vinyl cinnamate)under a strong pulse voltage,during which new energy-level trap states are *** prepared organic transistor nociceptors exhibit both structural and synaptic *** simulate the characteristics of human nociceptors,including threshold,relaxation,sensitization,and maladaptation *** the first time,we have simulated and explored the structural plasticity behavior in organisms based on electronic *** remarkably,the transistor nociceptors realize the reinput of information without forgetting the initial informa *** strategy developed for the preparation of organic transistor nociceptors provides insights for addressing the catastrophic forgetting in the lifelong learning of intelligent neuromorphic devices.

关键词： electric-induced cycloelimination structural plasticity organic nociceptors organic transistors metaplasticity

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Repetitive transcranial magnetic stimulation for post-traumatic stress disorder:Lights and shadows

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World Journal of Clinical Cases 2022年第17期10卷 5929-5933页

作者： Carmen Concerto Giuseppe Lanza Francesco Fisicaro Manuela Pennisi Alessandro Rodolico Giulia Torrisi Rita Bella Eugenio Aguglia Department of Clinical and Experimental Medicine Psychiatry UnitUniversity of CataniaCatania 95124Italy Department of Surgery and Medical-Surgical Specialties University of CataniaCatania 95123Italy Clinical Neurophysiology Research Unit Oasi Research Institute-IRCCSTroina 94018Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies“G.F.Ingrassia” University of CataniaCatania 95123Italy

We have read with interest the publication that describes the available data related to the use of neuromodulation strategies for the treatment of posttraumatic stress disorder(PTSD).Despite treatment advances,however,a substantial proportion of PTSD patients receiving psychological and/or pharmacological treatment do not reach an adequate clinical *** their paper,the authors draw attention to the current understanding of the use of repetitive transcranial magnetic stimulation(rTMS)as a potential treatment for *** of the previous studies indeed applied both inhibitory(1 Hz)and excitatory(>1 Hz,up to 20 Hz)rTMS to the right and/or left dorsolateral prefrontal *** larger therapeutic effects observed when high-frequency stimulation was applied,the question of which side and frequency of stimulation is the most successful is still *** authors also reported on the after-effect of rTMS related to neuroplasticity and identified the intermittent theta burst stimulation as a technique of particular interest because of it showed the most effective improvement on PTSD ***,although numerous studies have highlighted the possible beneficial use of rTMS protocols for PTSD,the exact mechanism of action remains *** their conclusions,the authors stated that rTMS has been demonstrated to be effective for the treatment of PTSD ***,we believe that further research with homogeneous samples,standardized protocols,and objective outcome measures is needed to identify specific therapeutic targets and to better define significant changes when active and sham stimulation procedures are compared.

关键词： Post-traumatic stress disorder Neuromodulation Repetitive transcranial magnetic stimulation Translational neuroscience Neuroplasticity metaplasticity

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Priming stimulation modifies synaptic plasticity in the perforant path of hippocampal slice in rat

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Neuroscience Bulletin 2006年第4期22卷 227-231页

作者： Lian ZHANG Hong-Mei XIAO Yan-Xia ZHOU Xiao-Ping LUO Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Physiology School of Basic Medical Science Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective The potential of all central nervous system synapses to exhibit long term potentiation （LTP） or long term depression （LTD） is subject to modulation by prior synaptic activity, a higher-order form of plasticity that has been termed metaplasticity. This study is designed to examine the plasticity and metaplasticity in the lateral perforant path of rat. Methods Field potential was measured with different priming and conditioning stimulation protocols. Results Ten-hertz priming, which does not affect basal synaptic transmission, caused a dramatic reduction in subsequent LTP at lateral perforant path synapses in vitro, and the reduced LTP lasted for at least 2 h. The LTD was unaffected. The reduction of LTP in the lateral perforant path was also readily induced by applying priming antidromically at the mossy fibers. Conclusion Priming with 10 Hz, which is within a frequency range observed during physiological activity, can cause potent, long-lasting inhibition of LTP, but not LTD. This form of metaplasticity adds a layer of complexity to the activity-dependent modification of synapses within the dentate gyrus.

关键词： metaplasticity hippocampus long term potentiation long term depression priming

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low-frequency stimulation in hippocampal CA1 slices from adult rats

low-frequency stimulation in hippocampal CA1 slices from adu...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Na-Na SHI,Li ZHANG,Ping LI,Tai-Zhen HAN Department of Physiology and Pathophysiology,Medical School of Xi''an Jiaotong University,Xi''an 710061

＜正＞Long-term potentiation（LTP） has been magnetic in its appeal because of its obvious potential for being a fundamental mechanism underlying the formation and storage of memory in the brain,especially in the hippocampus. Although LTP appears persistent,current work has provided evidence that various manipulations or pharmacological treatments when applied shortly after LTP induction can reverse *** reversal was effectively induced by different factors,such as afferent low-frequency stimulation（LFS）,brief cooling shocks,brief periods of hypoxia,application of adenosine receptor agonists and group I mGluR agonist（S）-3,*** kind of reversal of synaptic strength from a potentiated state to pre-LTP levels was referred to as depotentiation（DP）.Studies in the past decades have revealed several common features of *** among them is the time window of the applied reversal stimulation,that is the stimulation used to induce DP was effective if applied after the induction of LTP within a narrow time range（usually tens of min）.A number of electrical stimulation protocols have been reported to effectively induce DP immediately after LTP induction,including LFS,theta pulse stimulation and even high-frequency stimulation（HFS）.Despite the fact that reliable DP was obtainable 1h post-induction of LTP in the amygdala,it seemed impossible to evoke DP with such a long time interval after LTP induction in the adult *** present study aimed to determine whether LTP could still be reversed when the stimulation was applied beyond the optimal time window in hippocampal slices from adult *** excitatory postsynaptic potentials（fEPSPs） were recorded from the strata radiatum in CA1,following stimulation of Schaffer ***-burst stimulation（TBS） induced LTP that could be reversed by repeated paired-pulse LFS（PPLFS） after almost 3 h *** when synapse strength reached a plateau did application of PP-LFS trigger *** addition,it w

关键词： long-term potentiation depotentiation saturation metaplasticity theta-burst stimulation paired-pulse stimulation

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可供性与元可塑性：再探物质能动性论题

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科学技术哲学 2021年第11期

作者：夏永红李建会

文章回顾了认知考古学家马拉福瑞斯的共时的物质能动性论题，并尝试构想了一种历时的物质能动性论题。前者基于可供性概念，主张技能活动源于环境可供性的引导，而非人类的意图和规划；后者基于元可塑性概念，主张人类心灵与文化环境在... 详细信息

文章回顾了认知考古学家马拉福瑞斯的共时的物质能动性论题，并尝试构想了一种历时的物质能动性论题。前者基于可供性概念，主张技能活动源于环境可供性的引导，而非人类的意图和规划；后者基于元可塑性概念，主张人类心灵与文化环境在演化和发育过程中是相互塑造的，外部环境具有对认知演化和发育的能动性。通过对能动性条件的界定，文章论证了物质能动性的共时版本并不成立，它承诺的物质能动性更多是旨在破除人类中心论的修辞策略，而历时版本承诺的物质能动性则有可能在字面意义上是成立的。物质能动性论的历时版本不仅打破了心物二元的笛卡尔式图景，还进一步打破了基因完全决定的达尔文式图景，展现了一种更具动态性和建构性的世界现。

关键词：延展心灵认知过程物质能动性可供性元可塑性 extended mind cognitive process agency motility affordance metaplasticity

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