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A Critical Review on Traditional Herbal Drugs: An Emerging Alternative Drug for Diabetes

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International Journal of Organic Chemistry 2013年第1期3卷 1-22页

作者： Krishna Bihari Pandeya Indra Prasad Tripathi Mahendra Kumar Mishra Neelesh Dwivedi Yogesh Pardhi Arti Kamal Priyanka Gupta Nupa Dwivedi Chinmayi Mishra Faculty of Science & Environment Mahatma Gandhi Chitrakoot Gramoday Vishwavidyalaya Chitrakoot India Reseach Assistant Tropical Forest Research Institute (TFRI) Jabalpur India Research Scholar Mahatma Gandhi Chitrakoot Vishwavidyalaya Chitrakoot India Vice-Chancellor Mahatma Gandhi Chitrakoot Vishwavidyalaya Chitrakoot India

Diabetes is a chronic metabolic disease reaching an epidemic proportion in many parts of the world. By the year 2025 it is expected that 333 million people of the world will have diabetes as their main ailment. As today, India assumes the position of the diabetic capital of the world with the highest percentage of its population suffering from diabetes. It is pathetic to mention that in proportion to its people suffering from diabetes, this country has very weak spending power for treatment because of wide spread poverty. Therefore, this review is aimed at opening up new vistas in realizing the therapeutic potential of Ayurveda in treatment of diabetes and other chronic diseases. All drugs which we have discussed in this review have a significant role in therapy of diabetes mellitus.

关键词： Diabetes Mellitus Metabolic Disease Ayurveda Hyperglycemia Synthetic Drugs Herbal Drugs metallo Therapy Oral Hypoglycemic Drugs

THE ELECTRONIC CONFIGURATION OF 5-MEMBERED AND 6-MEMBERED RING SANDWICHES

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Chinese Science Bulletin 1982年第10期27卷 1063-1067页

作者：唐敖庆杨忠志冯星洪 Institute of Theoretical Chemistry Jilin University Changchun Shanghai Institute of Organic Chemistry Academia Sinican this paper a method of local symmetry is applied to metallo-organic 5-membered and 6-membered ring poly-decker sandwiches (briefly called 5-membered sandwich Ⅰ and 6-membered sandwich Ⅱ) and the nature of their chemical bond is discussed by means of the HMO theory. The stable electronic configuration for these sandwiches is obtained. A working rule for the total number of valence electrons being 6(2n+l)+4t is proposed. It is reasonable to suggest some potential synthetic goals of poly-decker sandwiches. The discovery in 1951 of the transition metal π-complex ferrocene created a new research field of metalloorganic sandwiches. Since then a lot of bis-decker sandwich-

In this paper, a method of local symmetry is applied to metallo-organic 5-membered and 6-membered ring poly-decker sandwiches (briefly called 5-membered sandwich Ⅰ and 6-membered sandwich Ⅱ), and the nature of their chemical bond is discussed by means of the HMO theory. The stable electronic configuration for these sandwiches is obtained. A working rule for the total number of valence electrons being 6(2n+l)+4t is proposed. It is reasonable to suggest some potential synthetic goals of poly-decker sandwiches. The discovery in 1951 of the transition metal π-complex, ferrocene, created a new research field of metalloorganic sandwiches. Since then, a lot of bis-decker sandwich-

关键词： sandwich membered briefly valence goals created symmetry metallo bonding orbital

KIDNEY AND URINARY TRACT

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China Medical Abstracts(Internal Medicine) 2002年第1期19卷 36-38页

BOND PARAMETRIC METHOD APPLIED TO BIO-INORGANIC CHEMISTRY

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Chinese Science Bulletin 1980年第11期25卷 937-941页

作者：陈念贻周国城 Shanghai Institute of Metallurgy Academia Sinica Shanghai Institute of Biochemistry Academia Sinica

The complex formation of metal ions with DNA, proteins and other bio-molecules plays a vital role in many biological processes and has been an important topic in bio-inorganaic chemistry. In recent years, the diseases... 详细信息

关键词： vital DNA deviation arder interact metallo 公犯 straight negativity 伍人

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ECONOMIC GEOLOGY

Abstracts of Chinese Geological Literature 2013年第3期29卷 54-55页

20131562 Chen Jianping(School of Earth Sciences and Resources,China University of Geosciences,Beijing 100083,China);Shi Rui 3D metallogenic Prediction for Western Section of Q8 Gold Deposit in Tongguan County of Shaan... 详细信息

关键词： Prediction Tianshan metallo stratigraphic shallow

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Ⅱ型胶原酶构建兔角膜离体扩张模型

中华眼视光学与视觉科学杂志 2016年第5期18卷 275-279页

作者：乔静李海丽宋文静汤韵荣蓓杨松霖吴元晏晓明北京大学第一医院眼科视觉损伤与修复教育部重点实验室 100034

目的探索使用Ⅱ型胶原酶建立兔角膜离体扩张模型的方法及其可行性.方法实验研究.20只离体兔角膜采用随机数字表法分为Ⅰ组（阴性对照组）、Ⅱ组（5 mg/mlⅡ型胶原酶组）、Ⅲ组（10 mg/mlⅡ型胶原酶组）及Ⅳ组（15 mg/mlⅡ型胶原酶组）... 详细信息

目的探索使用Ⅱ型胶原酶建立兔角膜离体扩张模型的方法及其可行性.方法实验研究.20只离体兔角膜采用随机数字表法分为Ⅰ组（阴性对照组）、Ⅱ组（5 mg/mlⅡ型胶原酶组）、Ⅲ组（10 mg/mlⅡ型胶原酶组）及Ⅳ组（15 mg/mlⅡ型胶原酶组）,每组5只角膜.刮除上皮后角膜置于人工前房上,各组采用不同浓度Ⅱ型胶原酶溶液浸泡60 min.分别记录处理前后各组角膜在不同人工前房内压力[模拟眼压（I0P）]下（15、30、45 mmHg）角膜平均曲率及角膜中央厚度,并对处理后各组角膜进行组织学检查.各组处理前后角膜平均曲率差值△Km及角膜中央厚度差值△CCT的变化采用单因素方差分析.结果不同IOP梯度下,4组角膜处理前后角膜平均曲率差值△Km差异有统计学意义（F=8.46、9.24、8.58,P＜0.01）;在各个IOP梯度下各组比较发现Ⅳ组与Ⅰ组的△Km差异均有统计学意义（P＜0.01）,Ⅱ组、Ⅲ组与Ⅰ组的△Km差异均无统计学意义（P＞0.05）.不同IOP梯度下,4组角膜处理前后角膜中央厚度差值△CCT差异均无统计学意义（F=0.22、0.66、1.60,P＞0.05）.与阴性对照组相比,胶原酶处理过的角膜基质胶原纤维排列疏松,基质水肿.结论 15 mg/mlⅡ型胶原酶溶液浸泡角膜60min能使角膜平均曲率增加,可用于建立兔角膜离体扩张模型.

关键词：基质金属蛋白酶8 圆锥角膜兔角膜扩张角膜曲率角膜厚度 Matrix metallo proteinase 8

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避免在畜间产生“超级细菌”

中国畜牧兽医文摘 2015年第1期31卷 11-11页

作者：呼格吉乐图孟和吉日嘎拉布仁宝力道内蒙古新巴尔虎左旗阿木古郎镇畜牧兽医工作站内蒙古呼伦贝尔021299 内蒙古新巴尔虎左旗新宝力格苏木农牧业服务中心内蒙古呼伦贝尔021212

超级病菌是对几乎所有抗生素有抗药性的细菌的统称。2011年4月卫生专家表示,一种几乎可以抵抗所有已知抗生素的超级细菌可能正在蔓延,对全球卫生构成威胁。这种细菌暂被命名为＂新德里超级细菌＂（New Delhi metallo-beta-lactamase 1,... 详细信息

超级病菌是对几乎所有抗生素有抗药性的细菌的统称。2011年4月卫生专家表示,一种几乎可以抵抗所有已知抗生素的超级细菌可能正在蔓延,对全球卫生构成威胁。这种细菌暂被命名为＂新德里超级细菌＂（New Delhi metallo-beta-lactamase 1,简称NDM-1）。NDM-1基因可以在多种细菌间转移,将普通细菌变成＂超级细菌＂。这种细菌能抵御除替加环素和多粘菌素之外的所有抗生素药效,其中一些细菌对现在所有抗生素都有耐药性。

关键词：超级细菌抗生素滥用替加环素 lactamase 超级病菌多粘菌素全球卫生 metallo 抗菌药物耐药菌