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Innovations and challenges of polyphenol-based smart drug delivery systems

Nano Research 2022年第9期15卷 8156-8184页

作者： Yanan Wang Jingwen Zhang Yi Zhao Minju Pu Xinyu Song Liangmin Yu Xuefeng Yan Jun Wu Zhiyu He Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China

Polyphenols,as widely existing natural bioactive products,provide a vast array of advanced biomedical applications attributing to their potential health benefits that linked to antioxidant,anti-inflammatory,immunoregulatory,neuroprotective,cardioprotective function,*** polyphenol compounds could dynamically interact and bind with diverse species(such as polymers,metal ions,biomacromolecules,etc.)via multiple interactions,including hydrogen bond,hydrophobic,π–π,and cation–πinteractions due to their unique chemical polyphenolic structures,providing far-ranging strategies for designing of polyphenol-based *** polyphenols emerged as multifaceted players,acting either as inherent therapeutics delivered to combat diverse diseases or as pivotal assemblies of drug delivery *** this review,we focused on the rational design and application of metal-phenolic network(MPN)based delivery systems,polyphenol-based coating films,polyphenol hollow capsules,polyphenolincorporated hydrogels,and polymer-polyphenol-based nanoparticles(NPs)in various diseases therapeutic,including cancer,infection,cardiovascular disease,neurodegenerative disease,*** versatility and mechanisms of polyphenols in the field of biomacromolecules(e.g.,protein,peptide,nucleic acid,etc.)delivery and cell therapy have been comprehensively *** through the literature review,the remaining challenges of polyphenol-containing nanosystems need to be addressed are involved,including long-term stability,biosafety in vivo,feasibility of scale-up,etc.,which may enlighten the further developments of this *** review provides perspectives in utilizing natural polyphenol-based biomaterials to rationally design next generation versatile drug delivery system in the field of biomedicine,which eventually benefits public health.

关键词： polymer-phenolic nanoparticles metal-phenolic network metal-phenolic coatings metal-phenolic hollow capsules polyphenol-protein interactions

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