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Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies

Regenerative Biomaterials 2024年第2期3卷 1-16页

作者： Xiaoqian Hong Geer Tian Yang Zhu Tanchen Ren Department of Cardiology of the Second Affliated Hospital and State Key Laboratory of Transvascular Implantation Devices Cardiovascular Key Laboratory of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310o09China Binjiang Institute of Zhejiang University Hangzhou 310053China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

metal ions participate in many metabolic processes in the human body,and their homeostasis is crucial for *** cardiovascular diseases(CVDs),the equilibriums of metal ions are frequently interrupted,which are related to a variety of disturbances of physiological processes leading to abnormal cardiac *** supplement of metal ions has the potential to work as therapeutic strategies for the treatment of *** with other therapeutic drugs,metal ions possess broad availability,good stability and safety and diverse drug delivery *** delivery strategies of metal ions are important to exert their ther-apeutic effects and reduce the potential toxic side effects for cardiovascular applications,which are also receiving increasing *** local delivery strategies for metal ions based on various biomaterials are constantly being *** this review,we comprehensively summarized the positive roles of metal ions in the treatment of cVDs from three aspects:protecting cells from oxidative stress,inducing angiogenesis,and adjusting the functions of ion *** addition,we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair,as well as the currently available engineered strategies for the precise delivery of metal ions,such as integrated with nanoparticles,hydrogels and scaffolds.

关键词： metal ions cardiovascular disease tissue engineering oxidative stress angiogenesis ion channel

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metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 230-240页

作者： Chen Chen Shan Yang Yufei Liu Yue Qiu Jing Yao State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals Department of PharmaceuticsChina Pharmaceutical UniversityNanjing 211198China

Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received considerable attention in biomedical applications. Herein, binary metal ions Mn(Ⅱ)/Fe(Ⅲ) are used to induce the formation of indocyanine green(ICG) ***, the sheet-like J-aggregates are able to act as "carriers" for loading hydrophobic chemotherapeutic gambogic acid(GA), realizing the effect of "killing two birds with one stone" for both treatment and delivery. The as-designed nanoassembly is formed spontaneously in aqueous environment via π-π stacking, electrostatic interaction, and hydrophobic force, exhibiting enhanced photostability of ICG and outstanding reactive oxygen species(ROS) generation ability. Moreover, significant inhibition of tumor growth by the synergetic effect of phototherapy and chemotherapy is verified in a subcutaneous4T1 tumors model. In conclusion, this work not only presents a facile and green approach to manufacture carrier-free nanodrugs, but also establishes a universal platform that has potential application in the co-delivery of near-infrared dye and hydrophobic molecules.

关键词： metal ions J-aggregates Combination therapy

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Dual-functional pyrene implemented mesoporous silicon material used for the detection and adsorption of metal ions

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中国化学工程学报:英文版 2023年第8期60卷 108-117页

作者： Jing Huang Honghui Cai Qian Zhao Yunpeng Zhou Haibo Liu Jing Wang School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China

A fluorescent active organic–inorganic hybrid material Py N-SBA-15 was synthesized by implementing pyrene derivatives into mesoporous SBA-15 *** N-SBA-15 had detection and removal functionalities toward Al^(3+),Cu^(2+),and Hg^(2+).On the one hand,Py N-SBA-15 was used as a fluorescence sensor and displayed high sensitivity toward Al^(3+),Cu^(2+),and Hg^(2+)cations (limit of detection:8.0×10^(-7),1.1×10^(-7),and 2.9×10^(-6)mol·L^(–1),respectively) among various analytes with“turn-off”*** the other hand,the adsorption studies for these toxic analytes (Cu^(2+),Hg^(2+),and Al^(3+)) showed that the ion removal capacity could reach up to 45,581,and 85 mg·g^(-1),***,the Langmuir isotherm models were better fitted with the adsorption data,indicating that the adsorption was mono-layer *** analysis revealed that the adsorption process was well described by the pseudo-second-order kinetic model for Cu^(2+)and Hg^(2+)and pseudo-first-order kinetic model for Al^(3+).The prepared silica material could be reused in four recycles without significantly decreasing its adsorption ***,the Py N-SBA-15 material can serve as a promising candidate for the simultaneous rapid detection and efficient adsorption of metal ions.

关键词： Dual function Nanomaterials Mesoporous silica metal ions Detection and adsorption

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Nucleobase,nucleoside,nucleotide,and oligonucleotide coordinated metal ions for sensing and biomedicine applications

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Nano Research 2022年第1期15卷 71-84页

作者： Jiaojiao Zhou Heyou Han Juewen Liu State Key Laboratory of Agricultural Microbiology College of Food Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Chemistry Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada

metal ions play critical roles in chemical,biological,and environmental *** biomolecules have the ability to coordinate with metal ions and form various ***,nucleosides,and nucleotides,as the essential components of DNA,have emerged as a useful building block for the construction of functional *** recent years,DNA oligonucleotides have also been used for this *** herein review the strategies for the synthesis of soft nanomaterials through the assembly of nucleotides(or DNA)and metal ions to yield various nanoparticles,fibers,and *** coordination methods are simple to operate and can be carried out under ambient *** luminescent,catalytic,and molecular recognition properties of these coordination materials are described with representative recent *** applications ranging from biosensing,enzyme encapsulation,catalysis,templated shell growth to cancer therapy are ***,challenges of this field and future perspectives are discussed.

关键词： nucleotides DNA metal ions self-assembly nanostructures

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A minimized fluorescent chemosensor array utilizing carboxylate-attached polythiophenes on a chip for metal ions detection

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 72-80页

作者： Yui Sasaki Xiaojun Lyu Zhoujie Zhang Tsuyoshi Minami Institute of Industrial Science The University of TokyoTokyo 153-8505Japan

Chemosensor arrays have a great potential for on-site applications in real-world ***,to fabricate on chemosensor array a number of chemosensors are required to obtain various optical patterns for multianalyte ***,we propose a minimized chemosensor array composed of only two types of carboxylate-functionalized polythiophene derivatives for the detection of eight types of metal *** recognition of the metal ions,the polythiophenes exhibited changes in their fluorescence intensity and various spectral *** both chemosensors have the same polymer backbone and recognition moiety,only the difference in the number of methylene groups contributed to the difference in the fluorescence response ***,the metal ions in aqueous media were successfully discriminated qualitatively and quantitatively by the chemosensor microarray on the glass *** study offers an approach for achieving a minimized chemosensor array just by changing the alkyl chain lengths without the necessity for many receptors and reporters.

关键词： metal ions polythiophene chemosensor array fluorescence pattern recognition

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Unravelling the effects of complexation of transition metal ions on the hydroxylation of catechol over the whole pH region

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Journal of Environmental Sciences 2022年第5期34卷 392-402页

作者： Zexiu An Jianfei Sun Qiong Mei BoWei Mingxue Li Ju Xie Maoxia He Qiao Wang Environment Research Institute Shandong UniversityQingdao 266237China School of Environmental and Materials Engineering Yantai UniversityYantai 264005China College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Catechol pollutants(CATPs)serving as chelating agents could coordinate with many metal ions to form various CATPs-metal *** information is available on the effects of complexation of metal ions on CATPs *** work presents a systematical study of·OH-mediated degradation of catechol and catechol-metal complexes over the whole pH range in advanced oxidation processes(AOPs).Results show that the pH-dependent complexation of metal ions(Zn^(2+),Cu^(2+),Ti^(4+)and Fe^(3+))promotes the deprotonation of catechol under neutral and even acidic *** radical adduct formation(RAF)reactions are both thermodynamically and kinetically favorable for all dissociation and complexa-tion species,and-OH/-O-group-containing C positions are more vulnerable to·OH *** kinetic results show that the complexation of the four metal ions offers a wide pH range of effectiveness for catechol *** pH 7,the apparent rate constant(k_(app))values for different systems follow the order of catechol+Ti^(4+)≈catechol+Zn^(2+)>catechol+Cu^(2+)>catechol+Fe^(3+)>*** mechanistic and kinetic results would greatly improve our understanding of the degradation of CATPs-metal and other organics-metal complexes in *** toxicity assessment indicates that the·OH-based AOPs have the ability for decreasing the toxicity and increasing the biodegradability during the processes of catechol degradation.

关键词： Catechol metal ions Complexation pH Degradation

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metal ions as effectual tools for cancer with traditional Chinese medicine

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Acupuncture and Herbal Medicine 2023年第4期3卷 296-308页

作者： Lei Wang Yingqiu Xie Sandugash Myrzagali Weiling Pu Erwei Liu State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Department of Biology School of Sciences and HumanitiesNazarbayev UniversityAstanaKazakhstan

Malignant tumor has become a major threat affecting human health,and is one of the main causes of human *** studies have shown that many traditional Chinese medicines(TCM)have good anti-tumor activity,which may improve the therapeutic effect of routine treatment and quality of life with lower ***,the efficacy of TCM alone for the treatment of tumors is *** ions are essential substances for maintaining normal physiological *** article summarized the multiple mechanisms in which metal ions are involved in the prevention and treatment of tumors in TCM.

关键词： metal ions Traditional Chinese medicine Treatment modalities Tumor development

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Chelation Assignments of Ga^Ⅲ,Ge^Ⅳand Si^Ⅳmetal ions WithPipemidic Acid Antibiotic Drug:Synthesis,Spectroscopic Characterizations and Biological Studies

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光谱学与光谱分析 2020年第10期40卷 3303-3308页

作者： Abeer A El-Habeeb Department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia

Pipemidic acid is one of an efficient quinolone antibacterial *** pipemidic acid“Hpipc”withgallium(Ⅲ),germanium(Ⅳ)and silicon(Ⅳ)afforded three molecular formulas of[Ga(pipc)2(H 2O)(Cl)]·4H 2O,1,[Ge(pipc)2(Cl)2]·4H 2O,2 and[Si(pipc)2(Cl)2]·4H 2O,3 *** three new complexes were characterized based on elemental analysis,conductance,FTIR,UV-Vis,^1HNMR and XRD *** pipc chelate exhibits O,O coordinated through the carbonyl(C O)and carboxylato(COO)of both oxygen *** coordinate geometry was proposed regarding complexes of 2 and 3,so the axial position was occupied by two coordinated *** vitro,the antibacterial,antifungal,and anti-cancer assessments concerning the synthesized pipc complexes were *** complexes have an excellent anti-microbial activity.

关键词： Pipemidic metal ions Chelation FTIR XRD Biological activity

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Interactions between metal ions and the biopolymer in activated sludge： quantification and effects of system pH value

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Frontiers of Environmental Science & Engineering 2017年第1期11卷 79-87页

作者： Yun Zhou Siqing Xia Binh T. Nguyen Min Long Jiao Zhang Zhiqiang Zhang State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and Engineering Tongji University Shanghai 200092 China Biodesign Swette Center for Environmental Biotechnology Arizona State University Tempe AZ 85287-5701 USA School of Civil Engineering and Transportation Shanghai Urban Construction Vocational College Shanghai 200432 China

The quantification and effects of system pH value on the interactions between Pb（II） and the biopolymer in activated sludge were investigated. The biopolymer had two protein-like fluorescence peaks （Ex/Em = 280 nm1326-338 nm for peak A; Ex/Em = 220-230 nm/324-338 nm for peak B）. The fluorescence intensities of peak B were higher than those of peak A. The fluorophores of both peaks could be largely quenched by Pb（ll）, and the quencher dose for peak B was about half of that for peak A. The modified Stern-Volmer equation well depicted the fluorescence quenching titration. The quenching constant （Ka） values for both peaks decreased with rising system pH value, and then sharply decreased under alkaline conditions. It could be attributed to that the alkaline conditions caused the reduction of available Pb（II） due to the occurrence of Pb（OH）2 sediments. The Ka values of peak B were bigger than those for peak A at the same system pH values. Accordingly, the aromatic proteins （peak B） played a key role in the interactions between metal ions and the biopolymer.

关键词： metal ions Biopolymer Activated sludge Three-dimensional excitation emission matrix (3D-EEM) Fluorescence regional integration (FRI) technique Quantification

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The Catalytic Effect of metal ions on the Degradation of 4-Chlorophenol Induced by an Aqueous Pulsed Discharge Plasma

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Plasma Science and Technology 2013年第7期15卷 677-684页

作者：郝小龙张兴旺雷乐成 School of Environmental and Civil Engineering Jiangnan University Institute of Industrial Ecology and Environment Zhejiang University

The influence of metal ions, such as Fe^2＋, Fe^3＋, Cu^2＋ and Mn^2＋, on 4-CP degrada-tion was investigated in an aqueous pulsed discharge plasma system with or without the addition of a TiO2 photo-catalyst. From an analysis of the pseudo first-order rate constant （kcp） and energy efficiency （G50%） for 4-CP degradation, the experimental results show that the degrada- tion of 4-CP is much enhanced in the presence of ferrous ions at the optimal concentration of 0.2-0.8 mmol/L or 0.2 mmol/L in an aqueous pulsed discharge plasma without or with the TiO2 system, respectively, and the enhancement is ascribed to plasma induced Fenton and photo-Fenton reactions. Meanwhile, the rank of such metal ions for catalytic effect on 4-CP degradation was Fe^2＋〉 Fe^3＋〉 Cu^2＋〉 Mn^2＋ and Fe^2＋〉 Fe^3＋〉 Mn^2＋〉 Cu^2＋ for the former and the latter systems, respectively, and the reasons behind this were discussed through the analysis of active species, especially hydrogen peroxide.

关键词： aqueous pulsed discharge plasma metal ions para-chlorophenol degradation,plasma catalysis

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