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Chinese Journal of Chemistry 2006年第6期24卷 739-744页

作者：张翠萍吴艳波杨频 Key Laboratory of Chemical Biology of Molecular Engineering of Ministry of Education at Institute of Molecular Science Shanxi University Taiyuan Shanxi 030006 China

In this work, the recognition of DNA including G：T mismatched pairs by the two different structures of [Ru（phen）2hpip]^2＋ was firstly studied with molecular modeling respectively. The results revealed that all of the four chiral isomers of the two structures could recognize the mismatched DNA from the minor groove orientation especially and the interaction was enantioselective and sitespecific. The two left isomers were more preferential than the right ones. Especially, the structure Ⅱ which had much lower energy after interacting with DNA was the advantaged structure. Detailed energy analysis indicated that the steric interaction in the process of the complex inserting base stack determined the recognition results and the electrostatic interaction made an effect to some extent.

关键词： metal complex molecular modeling steric collision electrostatic interaction

Modification of metal complex on the StereoselectiveHydrogenation of 2,3-Butanedione

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Chinese Chemical Letters 2001年第2期12卷 127-128页

作者： Yan LI Han Fan LIU PCLCC Center for Molecular ScienceInstitute of ChemistryChinese Academy of SciencesBeijing 100080

The modification of some metal complexes on Pt/Al2O3 clusters leads to remarkable increases in both the activity and the selectivity for meso-2,3-butanediol in the stereoselectivity hydrogenation of 2,3-butanedione.

关键词： stereoselective hydrogenation 2,3-butanedione metal complex platinum cluster

Synthesis, characterization, and anti-cancer activity of emodin-Mn(Ⅱ) metal complex

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Chinese Journal of Natural Medicines 2014年第12期12卷 937-942页

作者： YANG Li TAN Jun WANG Bo-Chu ZHU Lian-Cai Key Laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education College of Bioengineering Chongqing University School of Biological & Chemical Engineering Chongqing University of Education

To synthesize and characterize a novel metal complex of Mn(II) with emodin, and evaluate its anti-cancer activity. The elemental analyses, IR, UV-vis, atomic absorption spectroscopy, TG-DSC, 1H NMR, and 13 C NMR data were used to characterize the structure of the complex. The cytotoxicity of the complex against the human cancer cell lines HepG 2, HeL a, MCF-7, B16, and MDA-MB-231 was tested by the MTT assay and flow cytometry. Emodin was coordinated with Mn(II) through the 9-C=O and 1-OH, and the general formula of the complex was Mn(II)(emodin)2·2H2O. In studies of the cytotoxicity, the complex exhibited significant activity, and the IC50 values of the complex against five cancer cell lines improved approximately three-fold compared with those of emodin. The complex could induce cell morphological changes, decrease the percentage of viability, and induce G0/G1 phase arrest and apoptosis in cancer cells. The coordination of emodin with Mn(II) can improve its anticancer activity, and the complex Mn(II)(emodin)2·2H2O could be studied further as a promising anticancer drug.

关键词： Emodin Cytotoxicity metal complex Cell cycle arrest Apoptosis

Preparation of Carbon Nanotubes by the Catalysis of Polymer metal complex on Porous Al203 Matrix

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Chemical Research in Chinese Universities 2001年第Z1期17卷 95-96页

作者： SHI YanLi Department of Chemistry Lanzhou University

At present, synthesis of carbon nanotubes (CNTs) is normally conducted on a vapor-to-solid interface at ca. 500-3500℃ via various vapor phase methods, such as are discharge, laser ablation, catalytic pyrolysis and chemical vapor deposition, etc.1-2 Recently, channel materials (such as channels of alumina and of AlPO4-5 zeolite) 3 have been utilized as solid-state templates to grow CNTs inside the channel. Here we described a novel method to prepare the carbon nanotubes based on the decomposition of C2H2 gas on the Co-Ni catalyst anchored by polymer complex on the porous A12O3 matrix. The degree of graphitization of synthesized CNTs and catalysts are of great interest.

关键词： metal complex carbon nanotubes chemical vapor deposition polymer complex vapor phase

Preparation and Aqueous Recognition of metal complex Imprinted Polymer Using N-vinyl-2-pyrrolidone as Functional Monomer

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Chinese Journal of Chemical Engineering 2007年第4期15卷 595-599页

作者：王学军许振良邴乃慈杨座国 Chemicai Engineering Research Center East China University of Science and Technology Shanghai 200237 China

Using nickel（II） acetate.-2,2＇-dipyridyl complex as template and N-vinyl-2-pyrrolidone （NVP） as coordinate functional monomer,.a new kind of metal-compiexing template molecularly impnnted polymer （MIP） was prepared..The results of *** binding experiments in. aqueous solution showed that the MIP had higher＇binding capacity for nickel（ II ）-2,2＇-dipyridyl than the non-imprinted polymer with the same chemical composition. Theinfluences of metal ions and pHof solution on the recognition performance of MIP were investigated. The bindingcharacteristics of MIP were evaluated by the Scatchard analysis with one-site and two-site binding equations, respectively. The results on substrate selectivity of imprinted polymer revealed that MIP had better binding affinityfor template among thetested compounds.

关键词： molecularly imprinted polymer metal complex Scatchard plot recognition in water

APPLICATION OF IMPROVED MS—X_α METHOD TO d—d TRNSITION ENERGIES OF TRANSITION—metal complex

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Chinese Chemical Letters 1992年第6期3卷 441-444页

作者： Han Xing LIU Bo Fu LI Chia Chung SUN Advanced Materials Research Institute, Wuhan University of Technology, Wuhan, 430070 Institute of Theoretical Chemistry, Jilin University, Changchun, 130021

Based on X_α multiple scattering one-electron wave functions, a way for solving the many-electron Schrodinger equation by means of irreducible tensor method is reported. As an application, the analysis of the spectra... 详细信息

关键词： metal complex METHOD TO d d TRNSITION ENERGIES OF TRANSITION APPLICATION OF IMPROVED MS

Ultrafast time-resolved study of model DNAs and binding interactions between DNA and metal complex

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Ultrafast time-resolved study of model DNAs and binding inte...

Synthesis and Crystal Structure of the Novel Chiral o-Hydroxyphenyloxazoline metal complexes

中国化学会第30届学术年会-第四十四分会：化学动力学

作者： Chensheng Ma Wai-Ming Kwok David.L.Phillips Chi-Ming Che College of Chemistry and Environmental Engineering Shenzhen University Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Chemistry The University of Hong Kong

Study of the excited states of nucleic acids has been undergoing a revival in recent years impelled largely by femtosecond time-resolved spectroscopy. The properties and dynamics of nucleic acid excited states play a pivotal role in controlling both the photostability and the propensity towards photodamage of the genetic material, which is crucial for understanding evolution of life and is also essential for public health. Binding interactions between nucleic acids and metal complex have on the other hand found broad applications in areas such as develop of anticancer drug and sensory material, etc. In this presentation, we will demonstrate ultrafast spectroscopic study which we integrated fs broadband time-resolved fluorescence with fs transient absorption to characterize directly excited states of A/T model DNAs as well as to explore bindings between an platinum complex with a series of selected model and natural DNAs and RNAs. The results we obtained for A/T DNAs show that the electronic nature, energy, and decay dynamics of excited states all vary significantly with the composition, sequence, and conformation of the oligomeric *** bindings between platinum complex and nucleic acids, manifested by the energy and lifetime of emission from the interacting systems, exhibit critical dependence on the content and sequence of the nucleic acids. In particular, it was found that the intercalation of the complex into A/T containing DNAs may give rise to a highly emissive adduct with abnormally low emission energy and unusually long emission lifetime rarely reported in the literature. These findings provide important insights for in-depth understanding of the nucleic acid excited states and binding interactions of metal complex with nucleic acids, which may have important ramification for improving the applications in related areas.

关键词： DNA excited states time-resolved fluorescence transient absorption metal complex DNA binding

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Chinese Journal of Structural Chemistry 2003年第2期22卷 155-160页

作者：吴海臣杜大明花文廷金祥林 Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

The chiral o-hydroxyphenyloxazoline ligands were synthesized and their metal complexes with Cu, Ni and Ti were prepared. The crystal structure of complex 2a formed by ligand 1a with Cu (molar ratio 2:1) was determined by single-crystal X-ray diffraction analysis, and it belongs to monoclinic, space group P21 with a = 11.679(2), b = 17.681(4), c = 12.838(3) ? b = 106.50(3), C26H32N2O4Cu, Mr = 500.08, V = 2541.8(9) 3, Z = 4, F(000) = 1052, Dc = 1.307 g/cm3, m = 0.892 mm-1, the final R = 0.0448 and wR = 0.0930 (I > 2s(I)). In the asymmetric unit of complex 2a, there exist two types of molecules which are self-associated by intermolecular O…Cu interactions, and 揹imeric complex?is thus formed. The distances of the Cu and O atoms of a pair of intermolecular coordinated molecules are 2.828 ?for Cu(1)…O(21) and 2.776 ?for Cu(2)…O(13), respectively. The coordination N and O atoms and the central Cu are slightly deviated from coplanarity.

关键词： o-hydroxyphenyloxazoline metal complex self-assembly crystal structure

Synthesis, Spectroscopic and Electrochemical Investigations of Two vic-Dioximes and Their Mononuclear Ni（Ⅱ）, Cu（Ⅱ） and Co（Ⅱ） metal complexes Containing Morpholine Group

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Chinese Journal of Chemistry 2006年第11期24卷 1599-1604页

作者： KILIC, Ahmet TAS, Esref GUMGUM, Bahattin YILMAZ, Ismail Department of Chemistry Harran University Sanliurfa 63510 Turkey Department of Chemistry Dicle University Diyarbakir 21280 Turkey Department of Chemistry Technical University oflstanbul Istanbul Maslak 34469 Turkey

Two vic-dioxime ligands （LxH2） containing morpholine group have been synthesized from 4-[2-（dimethylaminoethyl）] morpholine with anti-phenylchloroglyoxime or anti-monochloroglyoxime in absolute THF at -15 ℃. Reaction of two vic-dioxime ligands with MCl2·nH2O （M： Ni, Cu or Co and n=2 or 6） salts in 1 ： 2 molar ratio afforded metal complexes of type [M（LxH）2] or [M（LxH）2·2H2O]. All of metal complexes are non-electrolytes as shown by their molar conductivities （Am） in DMF （dimethyl formamide） at 10^-3 mol·L^-1. Structures of the ligands and metal complexes have been solved by elemental analyses, FT-IR, UV-Vis, ^1H NMR and ^13C NMR, magnetic susceptibility measurements, molar conductivity measurements. Furthermore, redox properties of the metal complexes were investigated by cyclic voltammetry.

关键词： morpholine electrochemistry dioxime structure metal complex cyclic voltammetry

metal complexes with 8-Hydroxyquinoline: Synthesis and <i>In Vitro</i>Antimicrobial Activity

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Open Journal of Applied Sciences 2021年第1期11卷 1-10页

作者： Amira Cipurković Emir Horozić Snjež ana Marić Lejla Mekić Halid Junuzović Faculty of Natural Sciences and Mathematics University of Tuzla Tuzla Bosnia and Herzegovina Faculty of Technology University of Tuzla Tuzla Bosnia and Herzegovina Faculty of Pharmacy University of Tuzla Tuzla Bosnia and Herzegovina

In this paper, three complexes with 8-hydroxyquinoline (8-HQ) were synthesized, their spectral analysis was performed and the antimicrobial effect was examined in vitro. The stoichiometric ratio of the complex was determined conductometrically and spectrophotometrically. FTIR and UV/VIS spectroscopy were used for structural characterization. Antimicrobial activity was examined by diffusion technique on selected gram-positive and gram-negative bacteria, and C. albicans. Square planar and octahedral geometry complexes were synthesized by mixing in a molar ratio of 1:2 (M:L). Based on the spectral data, it is concluded that both oxygen and nitrogen atoms from 8-HQ are involved in the formation of the complex. The antimicrobial activity of the complexes is high, with zones of inhibition in the range of 15 - 28 mm. 8-HQ was shown to have a significantly higher ability to inhibit the growth of the tested microorganisms.

关键词： 8-HQ metal complex Antimicrobial Activity In Vitro Study