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PHOSPHO1 Serves as a Key metabolism-related Biomarker in the Tumorigenesis of Diffuse Large B-cell Lymphoma

Current Medical Science 2022年第4期42卷 754-768页

作者： Tian-rui CHEN Huang-ming CAO Yin WU Jiang-tao XIE Hai-feng LAN Li-na JIN Department of Medicine Shanghai Di An Medical Laboratory Co.LtdShanghai 200433China Department of Orthopedic Oncology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Hematology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Hematology Myeloma&Lymphoma Center Changzheng HospitalNaval Medical UniversityShanghai 200003China

Objective:Diffuse large B-cell lymphoma(DLBCL)is an aggressive type of non-Hodgkin *** to its genetic heterogeneity and abnormal metabolism,many DLBCL patients have a poor *** study investigated the key metabolism-related genes and potential ***:Differentially expressed genes,differentially expressed transcription factors(TFs),and differentially expressed metabolism-related genes(DEMRGs)of glucose and lipid metabolic processes were identified using the edgeR *** DEMRGs were screened by Lasso regression,and a prediction model was *** cell type identification by estimating relative subsets of RNA transcripts algorithm was utilized to assess the fraction of immune cells,and gene Set Enrichment Analysis was used to determine immune-related pathways.A regulatory network was constructed with significant co-expression interactions among TFs,DEMRGs,immune cells/pathways,and hallmark ***:A total of 1551 DEMRGs were identified.A prognostic model with a high applicability(area under the curve=0.921)was constructed with 13 *** of DLBCL was highly related to the neutrophil *** DEMRGs(PRXL2AB,CCN1,DECR2 and PHOSPHO1)with 32 TF-DEMRG,36 DEMRG-pathway,14 DEMRG-immune-cell,9 DEMRG-immune-gene-set,and 67 DEMRG-protein-chip interactions were used to construct the regulatory ***:We provided a prognostic prediction model based on 13 DEMRGs for *** found that phosphatase,orphan 1(PHOSPHO1)is positively regulated by regulatory factor X5(RFX5)and mediates MYC proto-oncogene(MYC)targeting the V2 pathway and neutrophils.

关键词： diffuse large B-cell lymphoma metabolism-related gene immune microenvironment regulatory network PHOSPHO1

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