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Diacylated anthocyanins from purple sweet potato(Ipomoea batatas L.)attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期24卷 587-601页

作者： Luhong SHEN Yang YANG Jiuliang ZHANG Lanjie FENG Qing ZHOU College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacy Wuhan City Central HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China

Studies have shown that targeting xanthine oxidase(XO)can be a feasible treatment for fructose-induced hyperuricemia and *** study aimed to evaluate the dual regulatory effects and molecular mechanisms of diacylated anthocyanins from purple sweet potato(diacylated AF-PSPs)on hyperglycemia and hyperuricemia induced by a high-fructose/high-fat *** body weight,organ index,serum biochemical indexes,and liver antioxidant indexes of mice were measured,and the kidneys were observed in pathological *** relative expression levels of messenger RNAs(mRNAs)of fructose metabolism pathway enzymes in kidney were detected by fluorescent real-time quantitative polymerase chain(qPCR)reaction technique,and the expression of renal transporter protein and inflammatory factor pathway protein was determined by immunohistochemistry(IHC)*** showed that diacylated AF-PSPs alleviated hyperuricemia in mice,and that this effect might be related to the regulation of liver XO activity,lipid accumulation,and relevant renal *** AF-PSPs reduced body weight and relieved lipid metabolism disorder,liver lipid accumulation,and liver oxidative stress,thereby enhancing insulin utilization and sensitivity,lowering blood sugar,and reducing hyperglycemia in ***,diacylated AF-PSPs restored mRNA levels related to renal fructose metabolism,and reduced kidney injury and *** study provided experimental evidence for the mechanisms of dual regulation of blood glucose and uric acid(UA)by diacylated AF-PSPs and their utilization as functional foods in the management of metabolic syndrome.

关键词： Diacylated anthocyanins from purple sweet potato(diacylated AF-PSPs) Hyperglycemia Hyperuricemia metabolism syndrome Regulation of renal function

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The Investigation of the Correlation between Metabolic syndrome and Chinese Medicine Constitution Types in Senior Retired Military Personnel of the People's Liberation Army

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Chinese Journal of Integrative Medicine 2012年第7期18卷 485-489页

作者：封颖璐郑国银凌昌全 Department of Geriatrics the 401st Hospital of the People's Liberation Army Department of Traditional Chinese Medicine Changhai Hospital of the Second Military Medicine University

Objective： To investigate the incidence of metabolic syndrome （MS） and the distribution of constitutional pattern in elderly retired personnel of the People＇s Liberation Army. Methods： Adopting the method of cross-sectional field investigation, from June to December in 2008, the investigation questionnaires were completed by the aged over 60 and collected from 69 military retired residences in the 4 cities of Shanghai, Nanjing, Hangzhou and Qingdao. Other data, including demographic characteristics, physiological characteristics, life style and former medical history, were collected and analyzed. The statistical analysis for the database was drawn up by the software Epidata 3.0. Results： A total of 4,502 people were included in this study, and 35.3% of them were diagnosed with MS. There was no obvious difference in mobility among ages （60 to 69, 70 to 79 and over 80, P〉0.05）. Referring to the MS patients in the 70s age group, both the phlegm- dampness and dampness-heat constitutional types were evidently higher than those in the 60s age group （P=0.019, P=O.O08）; while MS patients in 80s and older showed a significantly lower incidence of dampness- heat constitution than those in the 60s （P=O.O0）; and qi-deficiency constitution was obviously higher in the 80s age group than those in the other two groups （P=O.O0）. The top 3 constitutions in MS people were, respectively, phlegm-dampness, dampness-heat and qi-deficiency constitution; while in non-MS people, the top 3 constitutions were gentleness, qi-deficiency and phlegm-dampness. When the patient＇s body mass index （BMI） was more than 25 kg/m2, the rate of phlegm-dampness and dampness-heat constitution significantly increased, while the rate of qi-deficiency constitution declined; the discrepancy was significant （P=O.O0）. Conclusions： The prevalence rate of MS in military senior people was 35.3%, which did not vary among the three age groups. Phlegm-dampness, dampness-heat and qi-deficiency constitution were the three

关键词： aged metabolism syndrome body constitution clinical trial cross-sectional studies

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