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Fatty Acid Synthase Inhibitors from Plants and Their Potential Application in the Prevention of metabolic syndrome

Clinical oncology and cancer researeh 2011年第1期8卷 1-9页

作者： Wei-xi Tian Xiao-feng Ma Shu-yan Zhang Ying-hui Sun Bing-hui Li College of Life Sciences Graduate University of Chinese Academy of Sciences Beijing 100049 China College of Life Sciences Graduate University of Chinese Academy of Sciences Beijing 100049 China Institute of Biophysics Chinese Academy of Sciences Beijing 100101China Central Laboratory of Oncology Department Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China

Fatty acid synthase （FAS） attracts more and more attention recently as a potential target for metabolic syndrome,such as cancer, obesity, diabetes and cerebrovascular disease. FAS inhibitors are widely existed in plants, consisting of diversiform compounds. These inhibitors exist not only in herbs also in many plant foods, such as teas, allium vegetables and some fruits. These effective components include gallated catechins, theaflavins,flavonoids, condensed and hydrolysable tannins, thioethers,pentacyclic triterpenes, stilbene derivatives, etc, and they target at the different domains of FAS, showing different inhibitory mechanisms. Interestingly, these FAS inhibitor-contained herbs and plant foods and their effective components are commonly related to the prevention of metabolic syndromes including fatreducing and depression of cancer. From biochemical angle,FAS can control the balance between energy provision and fat production. Some studies have shown that the effects of those effective components in plants on metabolic syndromes are mediated by inhibiting FAS. This suggests that FAS plays a critical role in the regulation of energy metabolism, and the FAS inhibitors from plants have significant potential application value in the treatment and prevention of metabolic syndromes.

关键词： fatty acid synthase metabolic syndrome cancer metabolism inhibitor

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