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Application of Nuclear Magnetic Resonance Spectroscopy in metabolic differences and Potential Biomarkers Screening in Rats with Polycystic Ovary Syndrome

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Chinese Journal of Biomedical Engineering(English Edition) 2022年第4期31卷 160-167页

作者： YU Jia PAN Hai-feng WANG Han PAN Feng YANG Guang Jilin Province FAW General Hospital Changchun Jilin 130011China

Objective:To investigate the application of nuclear magnetic resonance(NMR)spectroscopy in the exploration of metabolic differences and potential biomarkers in rats with polycystic ovary syndrome(PCOS).Methods:PCOS model was established by subcutaneous injection of deoxy-epiandrosterone(DHEA)in 30 rats randomly selected from sixty 23-day-old SPF female SD rats and set as PCOS group,and the other 30 rats were subcutaneously injected with oil and set as oil group,PCOS model was successfully established by 20 days of injection in both groups,and blood samples were taken for biochemical detection and NMR detection analysis.At the same time,the body weight,ovarian weight and HE staining results of rats in both groups were observed.Results:Compared with the oil group,the rats in the PCOS group had higher body weight,ovarian weight and serum LH,FPG,T,E_(2)and HOMA levels,and lower serum FSH and INS levels(Pdifferences in blood metabolism between the PCOS model constructed by surface DHEA and the rats in the oil group.A total of 70 metabolites were detected in the serum samples of rats in the two groups by NMR technique,and 31 of them were different between the two groups,which can be classified into glucose,lipid,and and amino acid.There were significant differences in three metabolites,including isoleucine,valine,and creatine(Pdifferences in carbohydrate,lipid and amino acid metaboli

关键词： polycystic ovary syndrome nuclear magnetic resonance spectroscopy rats metabolic differences biomarkers

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