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Predicting CircRNA-Disease Associations Based on Improved Weighted Biased meta-structure

Journal of Computer Science & Technology 2021年第2期36卷 288-298页

作者： Xiu-Juan Lei Chen Bian Yi Pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China School of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Computer Science Georgia State UniversityAtlantaGA 30302U.S.A

Circular RNAs(circRNAs)are RNAs with a special closed loop structure,which play important roles in tumors and other *** to the time consumption of biological experiments,computational methods for predicting associations between circRNAs and diseases become a better *** the limited number of verified circRNA-disease associations into account,we propose a method named CDWBMS,which integrates a small number of verified circRNA-disease associations with a plenty of circRNA information to discover the novel circRNA-disease *** adopts an improved weighted biased meta-structure search algorithm on a heterogeneous network to predict associations between circRNAs and *** terms of leave-one-out-cross-validation(LOOCV),10-fold cross-validation and 5-fold cross-validation,CDWBMS yields the area under the receiver operating characteristic curve(AUC)values of 0.9216,0.9172 and 0.9005,***,case studies show that CDWBMS can predict unknow circRNA-disease *** conclusion,CDWBMS is an effective method for exploring disease-related circRNAs.

关键词： circular RNA(circRNA) circRNA-disease association meta-structure heterogeneous network

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Multi-layer quasi-zero-stiffness meta-structure for high-efficiency vibration isolation at low frequency

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1189-1208页

作者： Jiahao ZHOU Jiaxi ZHOU Hongbin PAN Kai WANG Changqi CAI Guilin WEN College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body The Ministry of Science and TechnologyChangsha410082China School of Mechanical Engineering Zhejiang Sci-Tech UniversityHangzhou310018China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004Hebei ProvinceChina

An easily stackable multi-layer quasi-zero-stiffness(ML-QZS)meta-structure is proposed to achieve highly efficient vibration isolation performance at low ***,the distributed shape optimization method is used to design the unit cel,i.e.,the single-layer QZS(SL-QZS)***,the stiffness feature of the unit cell is investigated and verified through static ***,the unit cells are stacked one by one along the direction of vibration isolation,and thus the ML-QZS meta-structure is ***,the dynamic modeling of the ML-QZS vibration isolation metastructure is conducted,and the dynamic responses are obtained from the equations of motion,and verified by finite element(FE)***,a prototype of the ML-QZS vibration isolation meta-structure is fabricated by additive manufacturing,and the vibration isolation performance is evaluated *** results show that the vibration isolation performance substantially enhances when the number of unit cells *** importantly,the ML-QZS meta-structure can be easily extended in the direction of vibration isolation when the unit cells are properly ***,the ML-FQZS vibration isolation meta-structure should be a fascinating solution for highly efficient vibration isolation performance at low frequency.

关键词： quasi-zero stiffness(QZS) meta-structure high efficiency low frequency vibration isolation

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