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Stem cell therapy for idiopathic pulmonary fibrosis: How far are we from the bench to the bedside?

Journal of Biomedical Science and Engineering 2013年第8期6卷 24-31页

作者： Zheng Wang Xiaoju Zhang Yi Kang Yanli Zeng Hongmei Liu Xiaoqian Chen Lijun Ma Department of Infectious Disease People’s Hospital of Zhengzhou University Zhengzhou China Department of Respiratory and Critical Care Medicine People’s Hospital of Zhengzhou University Zhengzhou China Department of Respiratory Medicine the Second People’s Hospital of Anhui Province Hefei China

Idiopathic pulmonary fibrosis (IPF) is characterized by exuberant apoptosis and inadequate regeneration of lung parenchyma cells. Intratracheal alveolar type II epithelial cell instillation alleviates lung inflammation and fibrosis. Resident lung epithelial stem cells, as well as exogenous mesenchymal stem cells, are capable of differentiating into lung epithelial cells and repair the injured lung. It is thus supposed that, either engraftment of exogenous stem cells, or methods facilitating endogenous lung stem cell proliferation, are promising treatments for IPF, a devastating disease. Arrays of cellular and animal studies have shown the potential of stem cells in alleviating experimental lung fibrosis. Moreover, clinical trials have been launched to investigate the potentials of cell-based therapy in IPF patients. We intend to discuss the newest advances on stem cell therapy in pulmonary fibrosis, particularly the advantages, promises, and possible hurdles to pass from the successes in laboratory experiments to the eventual clinical applications.

关键词： Pulmonary Fibrosis mesenchymal Stem Cells Tissue Engineering Embryonic Stem Cells Alveolar Epithelial Cell

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Rare Occurrence of Primary Chest Wall Bone Tumours

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Open Journal of Orthopedics 2012年第4期2卷 138-143页

作者： Bhaskar Mitra Anadi Roy Choudhury Palash Bhattacharya Biswanath Paul Department of Pathology Midnapore Medical College & Hospital Paschim Medinipur India Department of Pathology RG Kar Medical College & Hospital Kolkata India.

Primary tumors involving the bony skeleton of the chest wall are uncommon. After a retrospective review of the histopathology archive at our institution from Oct 08 to Mar 09 we found three malignant neoplasms affecting the rib, clavicle and the costal cartilages, one mesenchymal chondrosarcoma, one case of clear cell chondrosarcoma and an aggressive osteoblastoma each having distinctive histological diagnosis. Our limited experience in the occurrence of primary chest wall tumors showed that there are occurrences of rare bony lesions. A strong clinical suspicion, clinico-radiological correlation and histopathological confirmation are required for proper evaluation.

关键词： Primary Chest Wall Tumours mesenchymal Chondrosarcoma Clear Cell Chondrosarcoma Aggressive Osteoblastoma

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Anticancer Gene-engineered MSC-mediated Cancer Cell Death: An Imaging Demonstration

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Engineering（科研） 2012年第10期4卷 35-38页

作者： Xu-Yong Sun Zhuang Chen Mani R. Moniri Hong Lu Long-Jun Dai Garth L. Warnock Department of Surgery University of British Columbia Vancouver Canada Institute of Transplant Medicine 303 Hospital of PLA Nanning Guangxi China Laboratory of Infection and Immunity Affiliated Hospital of Luzhou Medical College Luzhou Sichuan China

This study was performed to demonstrate the transportation of an engineered MSC-produced intracellular anticancer gene product between mesenchymal stem cell (MSC) and cancer cells.? MSC-mediated anticancer strategy has held great promise owing to MSCs’ capacity of tumor-directed migration and the availability of specific anticancer genes.? All anticancer genes that have been used in previous MSC-mediated anticancer studies were limited in functioning via extracellular mechanisms, mainly because of the restriction by cell membrane to macromolecules including proteins.? In order to apply the majority of potent anticancer genes to the MSC-mediated anticancer system, a specifically designed expression vector which bears an intracellular anticancer gene, PTEN, is utilized to demonstrate the feasibility of the system in cancer therapies.? A transacting activator of transcription (TAT) was introduced into an expression vector followed by a segment for PTEN-RFP fusion protein.? A direct demonstration of PTEN-RFP transportation between MSC and cancer cells was obtained from direct co-cultures.? A marked cancer cell death was observed in indirect co-cultures with conditioned media from PTEN-transfected MSCs.? The demonstration of PTEN-engineered MSC-produced PTEN transportation indicates the feasibility of applying intracellular anticancer gene expression system in MSC-mediated strategies for cancer therapy.

关键词： Genetic Engineering mesenchymal Stem Cells Gene Therapy Cancer Therapy PTEN

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间叶瘤15例报告

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中华小儿外科杂志 1986年第2期8卷 94-96页

作者：贾和庚潘少川郭哲人北京儿童医院

间叶瘤是由原始中胚层间叶组织发生的肿瘤,又称为混合性中胚层肿瘤,它可由各种间叶组织组成,包括纤维组织、脂肪组织、粘液组织、血管组织、骨与软骨组织、肌肉组织和淋巴组织等.肿瘤内上述组织多少不等,由几种成分混合组成.间叶瘤又可... 详细信息

间叶瘤是由原始中胚层间叶组织发生的肿瘤,又称为混合性中胚层肿瘤,它可由各种间叶组织组成,包括纤维组织、脂肪组织、粘液组织、血管组织、骨与软骨组织、肌肉组织和淋巴组织等.肿瘤内上述组织多少不等,由几种成分混合组成.间叶瘤又可分为良性和恶性两种.本文收集北京儿童医院近年内病理诊断为'间叶瘤'的病例15例进行总结,就其病理特点、临床特点以及治疗进行介绍与讨论.

关键词：组织发生 clinical characteristics 间叶瘤 adipose tissue blood vessels 肿瘤中胚层 type mesenchymal collection pathology 脂肪组织血管组织纤维组织软骨组织淋巴组织临床特点肌肉组织混合儿童医院

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