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merlin全新的组合式8-up CTP系统

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今日印刷 1998年第4期 90-90页

作者：吴畏

丹麦Purup-Eskofot公司新近推出了一种全新的大对开内滚筒式可直接出软片和印版的直接制版机merlin,其输出幅面可达820mm×1080mm,并提供可由客户指定的头、尾打孔功能,采用氩离子激光曝光,具有1270dpi、2540dpi和3175dpi三级可调分辨率... 详细信息

丹麦Purup-Eskofot公司新近推出了一种全新的大对开内滚筒式可直接出软片和印版的直接制版机merlin,其输出幅面可达820mm×1080mm,并提供可由客户指定的头、尾打孔功能,采用氩离子激光曝光,具有1270dpi、2540dpi和3175dpi三级可调分辨率。merlin的操作系统为一种专用的控制软件Purup-Eskofot Commander,它可以在显示照排机配置、静态参数等的同时显示正在曝光的工作状态。

关键词：上版 up CTP 过稿软片印版 merlin 照排机照相排字机版材

merlin-Gerin公司铸造生产的发展:法国公司经营活动研究:述评

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管理观察 1997年第4期 13-13页

作者：陈云卿

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笔记本电脑和手持PC的无线PC卡调制解调器merlin无线PC卡

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电子测试 2000年第12期13卷 92-92页

EH101“灰背隼”（merlin）直升机

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航空知识 1996年第8期 50-50页

天高海阔任悠游NOVATEL merlin G201 GPRS PCMCIA卡

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新潮电子 2002年第7期 58-58页

新型抗缺血药物治疗急性冠状动脉综合征的评价:雷诺嗪用于减少非ST段抬高型急性冠状动脉综合征局部缺血的代谢效能(merlin)-TIMI36试验的试验设计与原理

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 18-18页

作者： Morrow D.A. Scirica B.M. Karwatowska-Prokopczuk E. 罗亮 TIMI Study Group Cardiovascular Division Department of Medicine Boston MA United States Dr.

Background: Despite advances in antithrombotic therapies and invasive technology, the risk of recurrent ischemic complications in patients with non-ST-elevation acute coronary syndromes(NSTE-ACSs) remains substantial. Ranolazine is a novel agent that inhibits the late sodium current thereby reducing cellular sodium and calcium overload and has been shown to reduce ischemia in patients with chronic stable angina. Study Design: merlin-TIMI 36 is a phase III, randomized, double-blind, parallel-group, placebo-controlled, multinational clinical trial to evaluate the efficacy and safety of ranolazine during long-term treatment of patients with NSTE-ACS receiving standard therapy(N=6500). Eligible patients are randomized 1 ∶1 to ranolazine or matched placebo, initiated as 200 mg intravenously over 1 hour, followed by an 80-mg/h infusion(40 mg/h for patients with severe renal insufficiency) for up to 96 hours and oral ranolazine ER 1000 mg BID or matched placebo until the end of study. The primary end point is the time to first occurrence of any element of the composite of cardiovascular death, myocardial infarction, or recurrent ischemia. Secondary end points include ischemia on Holter monitoring, hospitalization for new or worsening heart failure, quality of life measures, and exercise performance. The evaluation of longterm safety will include death from any cause and symptomatic documented arrhythmia. Recruitment began in October 2004. The trial will continue until 730 major cardiovascular events and 310 deaths are recorded with expected completion in 24 to 28 months. Conclusions: merlin-TIMI 36 will evaluate the role of ranolazine in the acute and chronic management of patients presenting with NSTE-ACS.

关键词： merlin ST段抬高 TIMI36 雷诺嗪局部缺血药物治疗试验设计长期安全性次要终点

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DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor

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Journal of Molecular Cell Biology 2019年第9期11卷 725-735页

作者： N.Max Schabla Koushik Mondal Patrick C.Swanson Department of Medical Microbiology and Immunology Creighton University2500 California PlazaOmahaNE 68178USA Present address:Institute of Cellular and Molecular Immunology Georg-August-University of GottingenMedical FacultyHumboldtallee 3437073 GottingenGermany Present address:Department of Ophthalmology Hamilton Eye InstituteUniversity of Tennessee Health Sciences Center930 Madison AvenueMemphisTN 38163USA

Cullin-RING ligases(CRLs)comprise a large group of modular eukaryotic E3 ubiquitin *** this family,the CRL4 ligase(consisting of the Cullin4[CUL4]scaffold protein,the Rbxl RING finger domain protein,the DNA damage-binding protein 1[DDB1],and one of many DDBl-associated substrate receptor proteins)has been intensively studied in recent years due to its involvement in regulating various cellular processes,its role in cancer development and progression,and its subversion by viral accessory *** discovered as a target for hijacking by the human immunodeficiency virus accessory protein r,the normal targets and function of the CRL4 substrate receptor protein DDBl-Cul4-associated factor 1(DCAF1;also known as VprBP)had remained elusive,but newer studies have begun to shed light on these ***,we review recent progress in understanding the diverse physiological roles of this DCAF1 in supporting various general and cell type-specific cellular processes in its context with the CRL4 E3 ligase,as well as another HECT-type E3 ligase with which DCAF1 also associates,called EDD/*** also discuss emerging questions and areas of future study to uncover the dynamic roles of DCAF1 in normal physiology.

关键词： V(D)J recombination merlin Dicer p53 EDD/DYRK2 TET Hippo

The CREB-Binding Protein Inhibitor Underlying a Promising Therapeutic Strategy in NF2-associated Meningioma

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The CREB-Binding Protein Inhibitor Underlying a Promising Th...

化浊解毒方对慢性萎缩性胃炎大鼠Hippo/YAP信号通路的影响

第十四届中国医师协会神经外科医师年会

作者：邓佼娇

Background: Neurofibromin 2（NF2）-associated meningiomas often cause severe neurologic morbidity and mortality without clearly effective medical treatments. Herein, to uncover novel therapeutic avenues in NF2-associated meningiomas, a focused drug screening in meningioma cells with different merlin expression pattern was performed in present study. Methods: A total of 346 patients with meningiomas was followed up. A 20-agent library covering a wide range of meningioma relevant targets was screened with 10 high-grade patient-derived meningioma cell lines, malignant meningioma cell lines IOMM-Lee（NF2 wildtype）, CH157-MN（NF2 deficient） and human astrocyte cell line HA1800. Therapeutic effects and biological mechanisms of the lead compound, ICG-001, in NF2-associated meningiomas were characterized in vitro and in patient-derived xenograft（PDX） models. Results: We found low merlin expression is associated with meningioma proliferation and poor clinical outcomes in a large patient series（n=346）. Interestingly, loss of merlin expression in high grade meningioma cells rendered sensitivity to ICG-001, a cA MP-responsive element binding（CREB）-binding protein（CBP） inhibitor. Treatment with ICG-001 alone reduced growth of NF2-associated xenografts in mice, as well. Mechanistically, ICG-001 reduces mitotic slippage and self-renewal in NF2-associated meningioma cells by inhibiting CBP function as a coactivator of Wnt/β-catenin-mediated transcription. We also provide further evidence that ICG-001 inhibits proliferation of NF2-associated meningioma cells at least partly through attenuating the FOXM1-mediated Wnt/β-Catenin ***: This study provides a rationale for the clinical evaluation of CBP inhibitors in the treatment of patients with NF2-associated meningiomas. Our findings uncover a novel mechanism of merlin/FOXM1/β-Catenin pathway to reduce cellular growth through therapeutic administration of ICG-001 in meningiomas.

关键词： Meningioma NF2 merlin ICG-001 FOXM1 β-Catenin

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化浊解毒方对慢性萎缩性胃炎大鼠Hippo/YAP信号通路的影响