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Erythrocyte membrane proteins and membrane skeleton

Frontiers in Biology 2007年第3期2卷 247-255页

作者： LU Yiqin LIU Junfan Department of Biochemistry Xiangya School of MedicineCentral South UniversityChangsha 410078China

Considerable advances in the research field of erythrocyte membrane were achieved in the recent two *** findings in the structure-function correlation and interactions of erythrocyte membrane proteins have attracted extensive *** progress was also made in the molecular pathogenesis of erythrocyte membrane *** in the composition,function and interac-tion of erythrocyte membrane proteins,erythrocyte mem-brane skeleton,and relevant diseases are briefly described and summarized here on the basis of domestic and world literatures.

关键词： erythrocyte membrane proteins interaction functional disorders membrane skeleton

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Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome

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Frontiers of Medicine 2022年第6期16卷 946-956页

作者： Yashuang Yang Guimei Li Yanzhou Wang Yan Sun Chao Xu Zhen Wei Shuping Zhang Ling Gao Sijin Liu Jiajun Zhao Department of Endocrinology Shandong Provincial HospitalShandong UniversityJinan250021China Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China Shandong Key Laboratory of Endocrinology and Lipid Metabolism Jinan250021China Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan250117China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China Department of Pediatric Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China Medical Social Work Office Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China

Prader—Willi syndrome(PWS)is a rare congenital disease with genetic alterations in chromosome *** genetic disorders and DNA methylation abnormalities involved in PWS have been investigated to a significant degree,other anomalies such as those in erythrocytes may occur and these have not been clearly *** the present study,we uncovered slight anemia in children with PWS that was associated with increased red blood cell(RBC)distribution width(RDW)and contrarily reduced hematocrit(HCT)***,the increased ratio in RDW to HCT allowed sufficient differentiation between the PWS patients from the healthy controls and,importantly,with individuals exhibiting conventional *** morphologic examinations revealed a significant deformity in erythrocytes and mild hemolysis in PWS *** mechanistic investigations unveiled compromised membrane skeletal assembly and membrane lipid composition,and revealed a reduced F-actin/G-actin ratio in PWS *** ascribed these phenotypic changes in erythrocytes to the observed genetic defects,including DNA methylation *** collective data allowed us to uncover RBC deformation in children with PWS,and this may constitute an auxiliary indicator of PWS in early childhood.

关键词： Prader-Willi syndrome early diagnosis erythrocyte deformation membrane skeleton membrane lipid

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