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Study on the mechanism of cholic acid derivatives in traditional Chinese medicine based on the regulation of gene expression

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 35-41页

作者： Yongchun Huang Jie Zhang Pengxiang Zhao Yufeng Ma Qiangqiang Jia Shoude Zhang State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China Department of Pharmacy Medical College of Qinghai UniversityXining 810016China Pharmacy Intravenous Admixture Services Qinghai University Affiliated HospitalXining 810016China

Objective:To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine(TCM)based on the regulation of gene ***:Genome-wide gene expression profiles of Michigan Cancer Foundation-7(MCF-7)cells treated with or without 4 cholic acid derivatives were detected by gene chip *** in upregulated and downregulated genes were analyzed using the Connectivity Map(CMap)*** affinity between cholic acid derivatives and the potential target was confirmed by molecular *** cholic acid derivative-regulated pathway enrichment analysis was performed by the STRING database,and the potential pathway was confirmed by in vitro experiments on MD Anderson-Metastatic Breast-231(MDA-MB-231)***:Compared with the reference genome in the CMap database,the gene expression profiles of cholic acid derivatives were similar to those of antipsychotic,anticancer,anti-inflammatory,and antiinfective *** them,4 derivatives were associated with antianxiety drugs,and molecular docking results showed that these compounds may act by binding to the ligand-binding site of gammaaminobutyric acid(GABA)***,the cytoskeletal pathway is one of the pathways enriched in the *** them,ursodeoxycholic acid showed significant inhibitory activity on the cytoskeleton formation of MDA-MB-231 ***:The gene expression detection method,combined with CMap and pathway enrichment analysis,could be used to study the mechanism of the active ingredients of *** addition,our research showed that cholic acid derivatives have a potential affinity for membrane receptors,where they can exert anxiolytic activity by modulating opioid receptor,GABA receptor,and dopamine ***,ursodeoxycholic and chenodeoxycholic acid inhibit cytoskeleton formation,probably by acting on membrane proteins to activate the corresponding cytoskeletal pathways.

关键词： Cholic acid derivatives Gene chip CMap Pathway enrichment analysis membrane receptors Cytoskeleton

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Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

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Cancer Drug Resistance 2020年第4期3卷 879-911页

作者： Serkan Yaman Uday Chintapula Edgar Rodriguez Harish Ramachandramoorthy Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010USA Joint Bioengineering Program University of Texas Southwestern Medical CenterDallasTX 75235USA

Nanotechnology-based drug delivery platforms have been developed over the last two decades because of their favorable features in terms of improved drug bioavailability and *** recent advancement in nanotechnology platforms,this approach still falls short to meet the complexity of biological systems and diseases,such as avoiding systemic side effects,manipulating biological interactions and overcoming drug resistance,which hinders the therapeutic outcomes of the NP-based drug delivery *** address these issues,various strategies have been developed including the use of engineered cells and/or cell membrane-coated *** membrane receptor profiles and characteristics are vital in performing therapeutic functions,targeting,and homing of either engineered cells or cell membrane-coated nanocarriers to the sites of *** this context,we comprehensively discuss various cell-and cell membrane-based drug delivery approaches towards cancer therapy,the therapeutic potential of these strategies,and the limitations associated with engineered cells as drug carriers and cell membrane-associated drug ***,we review various cell types and cell membrane receptors for their potential in targeting,immunomodulation and overcoming drug resistance in cancer.

关键词： Cell membrane-based drug delivery cell-mediated drug delivery membrane receptors drug carriers cancer drug resistance nanoparticles

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