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Anti-Obesity Effects of Dietary d-Allulose and medium-chain triglycerides in High-Fat Diet-Fed Rats

Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yokoyama Takako Yamada Tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose medium-chain triglycerides Body Fat Rat

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Consumption of medium-chain triglycerides improves immune status and gut microbiota in tunnel workers

Consumption of medium-chain triglycerides improves immune st...

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中国营养学会第十五届全国营养科学大会

作者： Qing Xu Huizi Li Yumeng Liu Peng Zhang Yong Zhang Xinsheng Zhang Yinghua Liu Department of Nutrition the First Medical Center of Chinese People's Liberation Army General Hospital Department of Nutrition PLA Rocket Force Characteristic Medical Center

Background and Objectives: Adverse environmental factors of tunnel increase the occurrence of respiratory and intestinal inflammatory disease, which is seriously harmful to workers health. Many studies have reported that mediumchain triglycerides(MCT) can improve immune status and alter the gut microflora. This study aims to investigate the effect of MCT on the immune status and gut microbiota of tunnel workers. Methods Methods and Study Design: Forty-five subjects were randomly divided into the MCT group(n=30) and control group(n=15), where they orally administered an MCT-milk or a placebo milk for 12 weeks, respectively. The primary outcome was the incidence of respiratory infections and diarrhea. Secondary outcomes were the changes in immune-related markers in serum and the changes in gut microbiota. Results Results: The incidence of diarrhea in MCT group was significantly decreased after 4 weeks intervention(p <0.01), while there were no significant changes in control group. MCT reduced the level of pro-inflammatory cytokines(TNF-α, CRP, and IL-6) and enhanced the anti-inflammatory cytokine(IL-10, C3, C4, IgA, IgG, and IgM), respectively(p <0.01). Chao index reduced(p <0.01) as well as microbiota composition changed significantly after 12 weeks MCT intervention. MCT significantly reduced the abundance of Bacteroides, Roseburia, Ruminococcus, Lachnospira and significantly increased that of Blautia and Fusicatenibacter at the genus level, respectively(p <0.01). Conclusion Conclusions: Our findings indicated that consumption of MCT reduced the diarrhea occurs, improved the serum immune profiles and gut microbiota in tunnel workers, which suggests that MCT may improve the immune status of tunnel workers by regulating gut microbiota.

关键词： medium-chain triglycerides tunnel environment immunity gut microbiota

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Coconut oil:what do we really know about it so far?

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Food Quality and Safety 2019年第2期3卷 61-72页

作者： Renan da Silva Lima Jane Mara Block Department of Food Science and Technology Federal University of Santa CatarinaFlorianópolisBrazil

In recent years,coconut oil has emerged as a potential‘miracle’*** media vehicles and health specialists assure that this fat is capable of promoting health benefits,such as weight reduction,cholesterol lowering,prevention of cardiovascular diseases,and anti-inflammatory effect,among *** claims are used to market the product and boost its sales by coconut oil ***,governmental regulatory agencies in many countries are still sceptical about the benefits obtained by the consumption of coconut oil due to its high-saturated fatty acid *** light of such controversy,this review focused on analysing the published literature on the alleged health claims,in order to investigate if there is enough scientific evidence to support *** was verified that the metabolism of lauric acid,the major fatty acid in coconut oil,remains *** studies reported that the product was not efficient in weight ***,it has been reported that the consumption of coconut oil increased low-density lipoprotein cholesterol,consequently increasing the risk of cardiovascular *** general,the studies present conflicting results and there is a lack of long-term human-based clinical ***,as a saturated fat,coconut oil should be consumed with moderation and the health allegations should not be used to market the product,once they are not scientifically proven so far.

关键词： lauric acid saturated fatty acids medium-chain triglycerides LDL cholesterol cardiovascular diseases

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