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ACETYLCHOLINESTERASE HISTOCHEMISTRY OF THE THALAMUS IN THE PRIMATE

Academic Journal of Xi'an Jiaotong University 2001年第2期13卷 101-106页

作者：刘健张巧俊 Department of Physiology Med. School of Xi'an Jiaotong Univ. Xi' an 710061 China

Objective To observe the distribution of acetylcholinesterase activity in the thalamus of the monkey.Methods Histochemical method was used to detect the acetylcholinesterase activity in the thalamus.Results Acetylcholinesterase was found to be inhomogeneous distribution in the primate thalamus and to reveal previously uncovered inhomogeneity within certain thalamic nuclei and their subdivisions. The medial, ventral and posterior nuclear groups displayed markedly uneven acetylcholinesterase reaction.In the mediodorsal nucleus,three distinct sbudivisions were revealed by acetylcholinesterase histochemistry, medial magnocellular part, ventral sector of central parvicellular part and dorsolateral sector of lateral pars multiformity showed weak, moderate and strong acetylcholinesterase activity, respectively. In the ventral nuclear group, acetylcholinesterase histochemistry was strong in the medial part of ventral posterior nucleus, moderate in the magnocellular part of ventral anterior, caudal, medial, oral and pars postrema parts of ventral lateral nucleus, as well as lateral part of ventral posterior nucleus, poor and weak in the inferior part of ventral posterior nucleus, par compacta of the medial part of ventral posterior nucleus and parvicellular part of ventral anterior nucleus. In the pulvinar nucleus, acetylcholinesterase reaction ranged from weak, moderate to strong in the parts of the oral, medial and lateral, as well as inferior of this nucleus, respectively. Regional variations of acetylcholinesterase activity within the thalamic nuclei and their subdivisions can help to identify them by acetylcholinesterase histochemistry. In addition, the dark patches of strong acetylcholinesterase activity contrasting with a lighter surrounding matrix were revealed within the parvicellular part and pars multiformis of mediodorsal nucleus, paracentral nucleus, central lateral nucleus, pars postrema part of ventral lateral nucleus and medial habenula nucleus, as well as medial part of pulvinar necleus, respectively.Conc

关键词： mediodorsal nucleus ventral thalamic nuclei acetylcholinesterase histochemistry thalamus monkey

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T-type Ca2+ channels in thalamic control of behavior

T-type Ca2+ channels in thalamic control of behavior

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Sukchan Lee Soojung Lee Huisu Kim Guk Bae Kim Ingie Hong Sukwoo Choi Sung-Yon Kim Sang Jeong Kim Hee-Sup Shin Department of Physiology SeoulNational University College of Medicine and Neuroscience Research Institute Medical Research CenterKorea School of Biological Sciences College of Natural SciencesSeoul National UniversityKorea Department of Physiology Seoul National University College of Medicine and Neuroscience Research Institute Medical Research CenterKorea

Objective The mediodorsal thalamus(MD) is a part of the limbic system and connects reciprocally with the prefrontal cortex,the amygdala and the hippocampus,which comprise a network of structures involved in fear memory. However,the contribution of the MD to fear behavior is poorly understood.Phospholipase C(PLC) b4 is expressed intensely in the MD but very lightly in the prefrontal cortex and the amygdala,the two key regions known to regulate fear extinction.Methods Here,we examined a role of the MD using the PLCb4 knock-out(PLCb4) mice in the formation and extinction of auditory-conditioned fear.Results The PLCb4 mice showed normal acquisition and long-term memory of auditory-conditioned fear.However,the mutant was severely impaired in fear extinction.Patch clamp recording on the mutant MD neurons in thalamic slices showed an increase of low threshold Ca currents mediated via T-type Ca channels compared to the wild type.An infusion in vivo of T-type channel blocker into the MD ameliorated the impaired extinction phenotype in PLCb4 and facilitated the extinction in wild type mice.Conclusion These results suggest that the mediodorsal thalamus is involved in the control of fear extinction and T-type Ca channels play an inhibitory role in this process.

关键词： T-type Ca2+ channels mediodorsal nucleus thalamus fear extinction

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