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Medicinal properties of Peganum harmala L. in traditional Iranian medicine and modern phytotherapy: a review

Journal of traditional Chinese medicine 2015年第1期35卷 104-109页

作者： Mina Cheraghi Niroumand Mohammad Hosein Farzaei Gholamreza Amin Department of traditional Pharmacy Faculty of Traditional Medicine Tehran University of Medical Sciences Faculty of Pharmacy Kermanshah University of Medical Sciences Department of Pharmacognosy School of Pharmacy and Medicinal Plants Research Center Tehran University of Medical Sciences

OBJECTIVE： To review the pharmacological activities of Peganum harmala L. （R harmala, Nitrariaceae） in traditional Iranian medicine （TIM） and mod- ern phytotherapy. METHODS： Opinions of TIM and modern phytotherapy about safety and acceptable dosage of this plant are discussed. Various medical properties of P. harmala were collected from important TIM references and added to scientific reports derived from modern medical databases like PubMed, Scirus, ScienceDirect and ***： The main medicinal part of the plant is the seed. In TIM resources, this plant possesses vari- ous Pharmacological activities such as carminative, galactagogue, diuretic, emmenagogue, antithrom-botic and analgesic. In modern phytotherapy, R harmala demonstrated numerous medicinal effects including cardiovascular, neurologic, antimicrobial, insecticidal, antineoplasmic, antiproliferative, gastrointestinal and antidiabetic effects. Adverse events such as neuro-sensorial symptoms, visual hallucination, bradycardia, hypotension, agitation, tremors, ataxia, abortion and vomiting cause peo- ple to use this plant cautiously. R harmala is contraindicated during pregnancy, due to its abortive and mutagenic activities. Because of increasing the expression of CYP1A2, 2C19, and 3A4 and inhi- bition of monoamine oxidase, the pharmacokinetic parameters of drugs which are mainly metabolized by these enzymes may be affected by R har- mala. CONCLUSION： The medicinal properties declared for this plant in TIM are compared with those showed in modern phytotherapy. Some of the TIM properties were confirmed in modern phytotherapy like emetic and analgesic activities and some have not been evaluated in modern phytotherapy such as its therapeutic effects on paralysis, epilepsy and numbness. Finally, the current review provides the evidence for other researchers to use TIM properties of P. harmala as an efficacious natural drug. Further preclinical and clinical studies for adequate evaluating safety and therape

关键词： Peganum harmala Pharmacologicalphenomena medicine, traditional Phytotherapy Review

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Perceptions of traditional,complementary and alternative medicine among conventional healthcare practitioners in Accra,Ghana:Implications for integrative healthcare

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Journal of Integrative medicine 2016年第5期14卷 380-388页

作者： Irene A.Kretchy Harry A.Okere Joseph Osafo Barima Afrane Joseph Sarkodie Philip Debrah Department of Pharmacy Practice and Clinical Pharmacy School of Pharmacy College of Health Sciences University of Ghana Department of Psychology School of Social Studies College of Humanities University of Ghana Department of Pharmacognosy School of Pharmacy College of Health Sciences University of Ghana Department of Pharmaceutics and Microbiology School of Pharmacy College of Health SciencesUniversity of Ghana

OBJECTIVE： Integrative medicine refers to ongoing efforts to combine the best of conventional and evidence-based complementary therapies. While this effort for collaboration is increasing, traditional complementary and alternative medicine （TM-CAM） remains poorly integrated into the current healthcare system of Ghana. At present, it is not clear if practitioners of mainstream medicine favor integrative medicine. The present study, therefore, sought to explore the perceptions of conventional healthcare professionals on integrative medicine. METHODS： A qualitative design composed of semi-structured interviews was conducted with 23 conventional healthcare professionals comprising pharmacists, physicians, nurses and dieticians from two quasi-government hospitals in Accra, Ghana. RESULTS： Participants＇ knowledge of TM-CAM was low, and although they perceived alternative medicine as important to current conventional healthcare in Ghana, they expressed anxieties about the potential negative effects of the use of TM-CAM. This paradox was found to account for the low levels of use among these professionals, as well as the low level of recommendation to their patients. The practitioners surveyed recommended that alternative medicine could be integrated into mainstream allopathic healthcare in Ghana through improving knowledge, training as well as addressing concerns of safety and efficacy. These findings are discussed under the themes： the knowledge gap, the paradox of TM-CAM, experience of use and prescription, and guided integration. We did not observe any differences in views among the participants. CONCLUSION： The conventional healthcare professionals were ready to accept the idea of integrative medicine based on knowledge of widespread use and the potential role of TM-CAM products and practices in improving healthcare delivery in the country. However, to achieve an institutional integration practitioners＇ understanding of TM-CAM must be improved, with specific attention

关键词： perceptions integrative medicine medicine, traditional complementary therapies healthcare qualitativeresearch Ghana

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A cross-sectional study of complementary and alternative medicine use in patients with coagulation disorders in Southern Iran

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Journal of Integrative medicine 2017年第5期15卷 359-364页

作者： Mohammadreza Bordbar Mehdi Pasalar Rezvan Aresehiri Sezaneh Haghpanah Soheila Zareifar Fatemeh Amirmoezi Hematology Research Center Shiraz University of Medical SciencesShiraz ***Iran Research Center for traditional Persian medicine and History of medicine Shiraz University of Medical SciencesShiraz ***Iran

OBJECTIVE：Complementary and alternative medicine（CAM）use has an increasing trend around the *** the wild application of CAM in patients with coagulation disorders,its efficacy is still questioned by many *** aim of this study was to determine the frequency and types of CAM usage,and the factors affecting CAM use among patients with bleeding ***：This cross-sectional study investigated the usage of CAM with a standard validated questionnaire in coagulopathic patients who were referred to Dastgheib Hospital,an educational therapeutic center affiliated to the Shiraz University of Medical Sciences in Shiraz,Southern ***：Between December 2015 and May 2016,75 patients were included in this *** hemophilia A and rare bleeding disorders were the most frequent among our ***,nearly half of the studied population（49.3%）used at least one CAM product or *** most common products were multivitamin（29.3%）,followed by folic acid（21.3%）and chamomile（12%）.32%of the patients resorted to faith *** main reasons of using CAM were reported to be increased general health,correction of anemia and thrombocytopenia and control of bleeding ***：CAM is being used frequently in patients with coagulation disorders like many other chronic illnesses all around the *** to emerging concern regarding the safety and possible interaction with the conventional medicine,it is necessary to develop basic data about the hematologic effects of these methods in order to use them more safely.

关键词： medicine, traditional complementary medicine alternative therapies coagulation disorder hemophilia Iran

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Leech therapy in treatment of cutaneous leishmaniasis:a case report

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Journal of Integrative medicine 2017年第5期15卷 407-410页

作者： Nasrin Hamidizadeh Amir Azizi Mohammad M.Zarshenas Sara Ranjbar Molecular Dermatology Research Center Shiraz University of Medical SciencesShirazIran Research Center for traditional medicine and History of medicine Shiraz University of Medical Sciences ShirazIran Departments of Phytopharmaceuticals(traditional)Pharmacy School of PharmacyShiraz University of Medical SciencesShirazIran Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazIran

1 IntroductionApplication of leeches has been a common treatment measure since ancient times and descriptions can be found in the works of Pliny,Galen,Avicenna and Themison.

关键词： leeching leishmaniasis, cutaneous medicine, traditional

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Phytochemical profile and biological activity of Juglans regia

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Journal of Integrative medicine 2016年第5期14卷 359-373页

作者： Nisha Panth Keshav Raj Paudel Rajendra Karki College of Pharmacy and Natural medicine Research Institute Mokpo National University Department of Oriental medicine Resource Mokpo National University

Juglans regia Linn. （Juglandaceae）, popularly known as English or Persian walnut, is a valuable medicinal plant with a potency to cure various diseases in traditional medicine, Since ancient time, different local ethnic groups have used various part of J. regia for a wide array of ailments including helminthiasis, diarrhea, sinusitis, stomach ache, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, anorexia, thyroid dysfunction, cancer and infectious diseases. Biological activities of J. regia have been reported in several peer review journals and scientific attention is increasing. The present review attempts to provide comprehensive information on plant description, ethnobotanical use, toxicity, phytochemical profile, pharmacology, clinical studies and current research prospective of the J. regia. Currently, there is an immense interest on isolation/identification of active constituents from walnut and screening those active compounds for pharmacological activities. In addition, researchers are performing clinical trials as well as screening various solvent extracts or fractions of J. regia in several animal diseases models to identify promising therapeutic benefits. In the present work, we review the latest information based on published scientific investigations of J. regia.

关键词： plant extracts Juglans regia medicine, traditional phytochemicals pharmacology

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A review on the pharmacological and toxicological aspects of Datura stramonium L.

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Journal of Integrative medicine 2013年第2期11卷 73-79页

作者： Bhakta Prasad Gaire Lalita Subedi Department of Herbal Pharmacology College of Oriental Medicine Kyung Hee University Department of Pharmaceutical Sciences School of Health and Allied Sciences Pokhara University

Datura stramonium L., a wild-growing plant of the Solanaceae family, is widely distributed and easily accessible. It contains a variety of toxic tropane alkaloids such as atropine, hyoscamine, and scopolamine. In Eastern medicine, especially in Ayurvedic medicine, D. stramonium has been used for curing various human ailments, including ulcers, wounds, inflammation, rheumatism and gout, sciatica, bruises and swellings, fever, asthma and bronchitis, and toothache. A few previous studies have reported on the pharmacological effects of D. stramonium; however, complete information regarding the pharmacology, toxicity, ethnobotany and phytochemistry remains unclear. Ethnomedicinally, the frequent recreational abuse of D. stramonium has resulted in toxic syndromes. D. stramonium, in the form of paste or solution to relieve the local pain, may not have a deleterious effect; however, oral and systemic administration may lead to severe anticholinergic symptoms. For this reason, it is very important for individuals, mainly young people, to be aware of the toxic nature and potential risks associated with the use of this plant. This comprehensive review of D. stramonium includes information on botany, phytochemistry, pharmacology, toxicology and ethnomedicinal uses.

关键词： Datura stramonium pharmacologic actions medicine, traditional phytotherapy drug toxicity review

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Functional constipation in children: non-pharmacological approach

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Journal of Integrative medicine 2015年第2期13卷 69-71页

作者： Majid Nimrouzi Mohammad M.Zarshenas Essence of Parsiyan Wisdom Institute Research Center for Traditional Medicine and History of MedicineShiraz University of Medical Sciences Research Institute for Islamic and Complementary medicine Iran University of Medical Sciences Department of Phytopharmaceuticals (traditional Pharmacy) School of Pharmacy Shiraz University of Medical Sciences

Teb （medicine） as described by Avicenna on the opening pages of the al-Qdngn fi al-Tibb （The Cannon of medicine） was ＂a science by which one learns the conditions of the human body in health and in the nonexistence of health to keep health or to bring it back＂. According to Avicenna＇s Canon of medicine and other traditional Persian medicine （TPM） resources, the observance of the six essential qualities provides guidance to any medical intervention. These qualities include air, food and drink, physical activity and rest, sleep and wake, retention and release （the bodily functions of absorption and evacuation） as well as mood and mental states. According to Avicenna＇s theory,

关键词： pediatrics constipation medicine, traditional

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