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Journal of Integrative medicine 2013年第6期11卷 422-427页

作者： Dagmar Ehling Oriental Health Solutions LLC.

Patients with a diagnosis of polycystic ovary syndrome （PCOS） are on the rise. About 4%-12% of women are currently estimated to have this condition. It is hypothesized that PCOS appears in women who have long-standing insulin resistance （1R）, which leads to high androgen and testosterone levels; this ultimately disrupts their menstrual cycles. Some researchers attribute IR to genetic factors, although there have been only minute changes in the human genome in the past 20 000 years. However, even with a stable gene pool, genes can be turned on and offby the environment, food and air quality and toxin exposure.

关键词： polycystic ovary syndrome infertility Hashimoto disease acupuncture therapy medicine, Chinese traditional medicine, herbal diet dietary supplements case reports

Complementary and alternative medicine use in Iranian patients with diabetes mellitus

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Journal of Integrative medicine 2015年第5期13卷 319-325页

作者： Mohammad Hashem Hashempur Mojtaba Heydari Seyed Hamdollah Mosavat Seyyed Taghi Heydari Mesbah Shams Noncommunicable Diseases Research Center Fasa University of Medical Sciences Department of Traditional medicine School of Medicine Fasa University of Medical Sciences Research Center for Traditional medicine and History of medicine Department of Traditional Persian Medicine School of Medicine Shiraz University of Medical Sciences Essence of Parsiyan Wisdom Institute Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences Health Policy Research Center Shiraz University of Medical Sciences Endocrine and Metabolism Research Center Nemazee Hospital Shiraz University of Medical Sciences

OBJECTIVE： There is increasing interest in complementary and alternative medicine generally, and especially by those affected by chronic diseases, such as diabetes mellitus. We aimed to determine the prevalence and pattern of complementary and altemative medicine use among patients suffering from diabetes mellitus in Shiraz, southern Iran. Another objective was to explore associated factors for use of complementary and alternative medicine among patients with diabetes mellitus. METHODS： A 19-item semi-structured questionnaire （open- and close-ended） was administered to 239 patients with diabetes mellitus in this cross-sectional study. It was carried out in two outpatient diabetes clinics affiliated with the Shiraz University of Medical Sciences, Shiraz, Iran. RESULTS： One hundred and eighty patients （75.3%） used at least one type of complementary and alternative medicine in the last year prior to the interview. Patients with diabetes mellitus who were living in a large family （〉 5 members）, not taking insulin, and believed that complementary and alternative medicine have synergistic effects with conventional medicine, were independently and significantly （P values： 0.02, 0.04, and 0.01, respectively） more likely to use complementary and alternative medicine. Most of the users （97.7%） reported use of herbal preparations, and 89.4% of users did not change their medication, neither in medication schedule nor its dosage. CONCLUSION： The use of complementary and alternative medicine, especially herbal remedies, is popular among diabetes patients in Shiraz, Iran. This use is associated with patients＇ family size, type of conventional medications and their view about concomitant use of complementary and conventional medicine.

关键词： diabetes mellitus complementary therapies prevalence medicine, herbal Iran.

Constituents of the anti-asthma herbal formula ASHMI^(TM) synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells,and eotaxin by human lung fibroblasts in vitro

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Journal of Integrative medicine 2013年第3期11卷 195-205页

作者： Bolleddula Jayaprakasam Nan Yang Ming-Chun Wen Rong Wang Joseph Goldfarb Hugh Sampson Xiu-Min Li Center for Chinese herbal Therapy for Asthma and Allergy Department of PediatricsIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Pneumology Weifang Asthma HospitalWeifang 261041Shandong ProvinceChina Department of Human Genetics Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Pharmacology and Systems Therapeutics Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA

OBJECTIVE： Anti-asthma herbal medicine intervention （ASHMITM）, a combination of three tradi- tional Chinese medicinal herbs developed in our laboratory, has demonstrated efficacy in both mouse models of allergic asthma, and a double-blind placebo-controlled clinical trial in patients with asthma. This study was designed to determine if the anti-inflammatory effects of individual herbal constituents of ASHMITM exhibited synergy. METHODS： Effects of ASHMI and its components aqueous extracts of Lingzhi （Ganoderma lucidum）, Kushen （Sophora flavescens） and Gancao （Glycyrrhiza uralensis）, on Th2 cytokine secretion by murine memory Th2 cells （D10.G4.1） and eotaxin-1 secretion by human lung fibroblast （HLF-1） cells were determined by measuring levels in culture supernatants by enzyme- linked immunosorbent assay. Potential synergistic effects were determined by computing interaction indices from concentration-effect curve parameters. RESULTS： Individual Lingzhi, Kushen and Gancao extracts and ASHMI （the combination of individual extracts） inhibited production of interleukin （IL）-4 and IL-5 by murine memory Th2 cells and eotaxin-1 production by HLF-1 cells. The mean 25%-inhibitory-concentration （IC2s） values （mg/mL） forASHMI, Lingzhi, Kushen and Gancao for IL-4 production were 30.9, 79.4, 123, and 64.6, respectively; for IL-5 production were 30.2, 263, 123.2 and 100, respectively; for eotaxin-1 were 13.2, 16.2, 30.2, and 25.1, respectively. The IC50values （mg/mL） for ASHMI, Lingzhi, Kushen and Gancao for IL-4 production were 158.5, 239.9, 446.7, and 281.8, respectively; for eotaxin-1 were 38.1, 33.1, 100, and 158.5, respectively. The interaction indices of ASHMI constituents at IC25 were 0.35 for IL-4, 0.21 for IL-5 and 0.59 for eotaxin-l. The interaction indices at IC^0 values were 0.50 for IL-4 and 0.62 for eotaxin-1 inhibition. Inhibition of IL-5 did not reach IC^0 values. All interaction indices were below 1 which indicated synergy. CONCLUSION： By comparing the interactio

关键词： medicine, Chinese traditional medicine, herbal plant extracts anti-asthma herbal medicine intervention (ASHMI) anti-asthmatic agents chemokine CCL11 interleukin-4 interleukin -5 in vitro

Pharmacological characteristics of Kampo medicine as a mixture of constituents and ingredients

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Journal of Integrative medicine 2013年第1期11卷 11-16页

作者： Hiroyasu Satoh Health Life Science Shitennoji UniversityHabikino Osaka 583-8501 Japan

herbal medicine in Japan is termed as Kampo medicine, which is derived from traditional Chinese medicine. Shakuyakukanzoto （Shao-Yao-Gan-Cao-Tang） as a kind of Kampo formulations is composed of just two components; Paeoniae Radix and Glycyrrhizae Radix, which produced marked relaxation of intestinal tract. Mokuboito （Mu-Fang-Ji-Tang） inhibited cardiac ionic channel currents, and as a mixture also produced great vasodilatation. Sinomenine （a main ingredient of Mokuboito） as a single compound also caused the vasodilatation, but decreased it along with ageing. Gypsum containing in Mokuboito and Chotosan （Diao-Teng-San） caused more marked effects, as compared with those without Gypsum. On the other hand, Rokumigan （Liu-Wei-Wan）, Hachimijiogan （Ba-Wei-Di-Huang-Wan） and Goshajinkigan （Niu- Che-Shen-Qi-Wan） increase in order the number of contained ingredients. The formulations with more herbs （ingredients） produced much more effective actions on rat aorta, presumably due to compensation of the decline of pharmacological sensitivity with ageing. Thus, there are some important differences between single chemical drugs and mixture drugs with many ingredients. The effects of Kampo medicine （mixture） are never just a sum of each effect induced by a lot of in qredients. For elder persons, furthermore, Kampo medicine exerts more effective actions.

关键词： Kampo medicine multiple compounds medicine, herbal anti-ageing drugs vasodilatation rats

Saffron (Crocus sativus L.) and major depressive disorder:a meta-analysis of randomized clinical trials

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Journal of Integrative medicine 2013年第6期11卷 377-383页

作者： Heather Ann Hausenblas Debbie Saha Pamela Jean Dubyak Stephen Douglas Anton Department of Sport and Exercise Sciences Jacksonville University Department of Aging and Geriatric Research University of Florida

Due to safety concerns and side effects of many antidepressant medications, herbal psychopharmacology research has increased, and herbal remedies are becoming increasingly popular as alternatives to prescribed medications for the treatment of major depressive disorder （MDD）. Of these, accumulating trials reveal positive effects of the spice saffron （Crocus sativus L.） for the treatment of depression. A comprehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted. OBJECTIVE： The purpose of this study was to conduct a meta-analysis of published randomized controlled trials examining the effects of saffron supplementation on symptoms of depression among participants with MDD. SEARCH STRATEGY： We conducted electronic and non-electronic searches to identify all relevant randomized, double-blind controlled trials. Reference lists of all retrieved articles were searched for relevant studies. INCLUSION CRITERIA： The criteria for study selection included the following：（1） adults （aged 18 and older） with symptoms of depression, （2） randomized controlled trial, （3） effects of saffron supplementation on depressive symptoms examined, and （4） study had either a placebo control or antidepressant comparison group. DATA EXTRACTION AND ANALYSIS： Using random effects modeling procedures, we calculated weighted mean effect sizes separately for the saffron supplementation vs placebo control groups, and for the saffron supplementation vs antidepressant groups. The methodological quality of all studies was assessed using the Jadad score. The computer software Comprehensive Meta- analysis 2 was used to analyze the data. RESULTS： Based on our pre-specified criteria, five randomized controlled trials （n = 2 placebo controlled trials, n = 3 antidepressant controlled trials） were included in our review. A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms （M ES = 1.62, P 〈

关键词： Crocus depressive disorder dietary supplements mood disorders quality of life medicine, herbal meta-analysis