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A little goes a long way: CLE peptides mediate phloem initiation

Journal of Integrative Plant Biology 2019年第10期61卷 1034-1035页

作者： Amala John Zachary L.Nimchuk Department of Biology University of North Carolina at Chapel Hill

The root system of a tree can often extend many-fold the diameter of the tree;it provides physical support, dissolved minerals and water but relies on a constant supply of nutrients from photosynthetically active tissues in aboveground organs. The phloem is re-sponsible for such transport and the success of a plant relies heavily on the integrity of the phloem in its root system.

关键词： CLE peptides mediate initiation

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Study on the protective effect of VitE on the nAchR in PC12 cells

Study on the protective effect of VitE on the nAchR in PC12 ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jian-Ying TIAN~*,Li-Jun MA,Peng CHE,Wei MA,Zhen-Hua MIAO Department of anatomy,Basic medical college,Ningxia Medical University,Yinchuan 750004,China

Objective Multiple lines of evidence have implicated nicotinic transmission in the pathology of Alzheimer’s disease(AD).Oxygen-free radicals and lipid hydroperoxides may have an aetiological role in the development of lesions in the central nervous system in patients with Alzheimer’s *** inα7 nicotinic acetylcholine receptor (nAChR),is responsible for attentional and cognitive deficits in *** provide useful information for finding drug candidates for the treatment of AD,a study was carried out To detect the effect of VitE on theα7nAChR injuried by HO / *** The cell viability was mesured by MTT ***α7nAChR protein level was identified by BCA and Dot ***(1)Compared with contrast group,the cells significantly decreased after treated with 100μM HO/ Fe.(2) The viability attenuated pretreated with VitE in 20μM,40μM,60μM(P<0.05,P<0.05,P<0.01).(3)The protein level ofα7nAChR reduced significantly(P<0.01),but was improved if pretreated with VitE in a dose-dependent way(20μM group (P<0.05),40μM,60μM group(P<0.01).Conclusion Subjects with dementia attributed to Alzheimer’s disease have a degree of disturbance in antioxidant balance which may predispose to increased oxidative *** may be a potential therapeutic area for antioxidant supplementation,such as VitE.

关键词： VitE mediate antioxidant protection

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S2A-3 The Alpha6*-nAChR is A Highly Sensitive Target for Low Dose Alcohol

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神经药理学报 2018年第4期8卷 36-37页

作者： WU Jie Division of Neurology Barrow Neurological InstituteSt.Joseph’s Hospital and Medical CenterPhoenix AZ 85013USA

Alcohol use disorder(AUD)is a serious public health problem that affects approximately 17 million Americans and results in tremendous social,legal and medical costs to the *** other addictive drugs(e.g.,morphine,cocaine or nicotine)that have specific molecular targets,ethanol(EtOH)has no specific *** most previous studies,EtOH concentrations used for investigation were too high(e.g.,>50 mmol·L-1)compared to the EtOH concentrations in human brain after alcohol drinking,and the high dose EtOH may produce nonspecific modulations of a variety of receptors,ion channels,intracellular signaling cascades,and gene expression in the ***,it is important to understand low dose(e.g.,mediate the sensitivity to low dose EtOH remain to be *** containingα6 subunits(α6*-nAChRs)shows a highly restricted distribution in midbrain dopaminergic neurons that are associated with drug dependence and ***,we report that low dose EtOH(0.1~5 mmol·L-1)significantly potentiatesα6*-nAChR function using patch-clamp whole-cell *** EtOH modulatesα6*-nAChR-mediated function depending on both EtOH and nicotine concentrations,representing a positive allosteric *** conclusion,our results demonstrate a functionalα6*-nAChR transfected in human SH-EP1 cells that can be used as an excellent cell model to investigateα6*-nAChR function and *** patch-clamp recording condition,low dose EtOH modulatesα6*-nAChR function as a positive allosteric *** this mechanism,brainα6*-nAChRs may play a critical role in mediating low dose alcohol’effects on alcohol reward and dependence.

关键词： EtOH mediate the sensitivity

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