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Chinese Journal of Chemical Engineering 2004年第2期12卷 196-201页

作者：张焕军朱国才 Institute of Nuclear and New Energy Technology Tsinghua University Beijing 102201 China

The carbonization of magnesium oxide particles by CO2 was investigated using a stirring mill reactor. The effects of the system temperature, stirring rotation speed, influx rate of CO2 and initial diameter of the magnesium oxide particles on the carbonization process were determined, The results show that the system temperature and the stirring rotation speed are the most significant influencing factors on the carbonization rate. The determi-nation of critical decomposition temperature (CDT) gives the maximum carbonization rate with other conditions fixed. A theoretical model involving mass transfer and reaction kinetics was presented for the carbonization process. The apparent activation energy was calculated to be 32.8kJ·mol-1. The carbonization process is co-controlled by diffusive mass transfer and chemical reaction. The model fits well with the experimental results.

关键词： mechanical force kinetics carbonization magnesium oxide mass transfer

Distortion of frontal bones results from cell apoptosis induced by the mechanical force from the migrating eye during metamorphosis in Paralichthys olivaceus

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Distortion of frontal bones results from cell apoptosis indu...

Nanoscale domain switching mechanism of Bi_(3.15)Eu_(0.85)Ti_3O_(12) thin film under the different mechanical forces

第二届全国发育生物学大会

作者： Mingyan Sun Baolong Bao Shanghai Ocean University

The left/right asymmetry of adult flatfishes(Pleuronectiformes)is remarkable given the external body symmetry of the larval *** asymmetry of the cranium mainly results from distortion of the frontals during metamorphosis in ***,it is showed that distortion of frontal bones is caused by the migrated ***,the molecular mechanism on regulating the distortion of the frontals is *** this study,we first show that distortion of frontal bones during metamorphosis in Paralichthys olivaceus is the result of cell apoptosis,rather than cell autophage or cell ***,we found that the cell apoptosis in frontals is induced by the mechanical force transferred from the eye upward migration in *** force signal from the up-migrating eye transmit from FAK to downstream gene and are integrated into the BMP-2 signal ***,it is clear that the cell apoptosis in frontal bones is activated by the intrinsic mitochondrial pathway under *** extrinsic death receptor should not be involved in the *** addition,the cell apoptosis in frontal bones in *** was not induced directly by thyroid hormone,which is regarded as to mediate cell apoptosis directly during amphibian *** findings help us to outline the major signaling route regulating the distortion of frontals during metamorphosis in ***,they tell us that the asymmetry of the cranium,at least the distortion of frontals,is rather the result than the reason of eye *** finding is important to better understand the evolution of flatfishes.

关键词： flatfishes frontal bones cell apoptosis mechanical force eye migration metamorphosis

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Chinese Physics B 2015年第10期24卷 496-500页

作者：朱哲陈玉博郑学军 School of Materials Science and Engineering Xiangtan University School of mechanical Engineering Xiangtan University

The switching process of ferroelectric thin films in electronic devices is one of the most important requirements for their application. Especially for the different external fields acting on the film surface, the mechanism of domain switching is more complicated. Here we observe the nanoscale domain switchings of Bi3.15Eu0.85Ti3O12 thin film under different mechanical forces at a fast scan rate. As the force increases from initial state to 247.5 n N, the original bright or grey contrasts within the selected grains are all changed into dark contrasts corresponding to the polarization vectors reversed from the up state to the down state, except for the clusters. As the mechanical force increases to 495 n N, the color contrasts in all of the selected grains further turn into grey contrasts and some are even changed into grey contrasts completely showing the typical 90° domain switching. When another stronger loading force 742.5 n N is applied, the phase image becomes unclear and it indicates that the piezoelectric signal can be suppressed under a sufficiently high force, which is coincident with previous experimental results. Furthermore, we adopt the domain switching criterion from the perspective of equilibrium state free energy of ferroelectric nanodomain to explain the mechanisms of force-generated domain switchings.

关键词： thin film domain switching mechanical force piezoresponse force microscopy

Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment

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Cancer Biology & Medicine 2023年第1期20卷 44-55页

作者： Pengfei Zhu Hongrui Lu Mingxing Wang Ke Chen Zheling Chen Liu Yang Cancer Center Department of Medical OncologyZhejiang Provincial People's Hospital(Affiliated People's HospitalHangzhoul Medical College)Hangzhou 310014China Graduate School of Clinical Medicine Bengbu Medical CollegeBengbu 233000China Department of Gastroenterology&Pancreatic Surgery Zhejiang Provincial People's HospitalHangzhou 310014China

mechanical forces in the tumor microenvironment(TME)are associated with tumor growth,proliferation,and drug *** mechanical forces in tumors alter the metabolism and behavior of cancer cells,thus promoting tumor progression and *** signals are transformed into biochemical signals,which activate tumorigenic signaling pathways through mechanical *** immunotherapy has recently made exciting progress,ushering in a new era of“chemo-free”***,immunotherapy has not achieved satisfactory results in a variety of tumors,because of the complex tumor ***,we discuss the effects of mechanical forces on the tumor immune microenvironment and highlight emerging therapeutic strategies for targeting mechanical forces in immunotherapy.

关键词： mechanical force microenvironment immunotherapy extracellular matrix cancer

Dynamics of perinuclear actin ring regulating nuclear morphology

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1415-1428页

作者： Haoxiang YANG Houbo SUN Jinghao SHEN Hao WU Hongyuan JIANG CAS Key Laboratory of mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230026China

Cells are capable of sensing and responding to the extracellular mechanical microenvironment via the actin *** vivo,tissues are frequently subject to mechanical forces,such as the rapid and significant shear flow encountered by vascular endothelial ***,the investigations about the transient response of intracellular actin networks under these intense external mechanical forces,their intrinsic mechanisms,and potential implications are very ***,we observe that when cells are subject to the shear flow,an actin ring structure could be rapidly assembled at the periphery of the *** gain insights into the mechanism underlying this perinuclear actin ring assembly,we develop a computational model of actin *** demonstrate that this perinuclear actin ring assembly is triggered by the depolymerization of cortical actin,Arp2/3-dependent actin filament polymerization,and myosin-mediated actin network ***,we discover that the compressive stress generated by the perinuclear actin ring could lead to a reduction in the nuclear spreading area,an increase in the nuclear height,and a decrease in the nuclear *** present model thus explains the mechanism of the perinuclear actin ring assembly under external mechanical forces and suggests that the spontaneous contraction of this actin structure can significantly impact nuclear morphology.

关键词： mechanical force actin dynamics perinuclear actin ring compressive stress nucleus

Pressure-Driven Contact Mechanics Evolution of Cathode Interfaces in Lithium Batteries

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Acta Mechanica Solida Sinica 2023年第1期36卷 65-75页

作者： Min Chen Lingyun Xiao Honglei Dong Jie Fan Xin Zhang Defective Product Administrative Center State Administration for Market RegulationBeijing 100101China China Merchants Testing Vehicle Technology Research Institute Co. Ltd.Chongqing 400000China School of mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

The interfacial instability due to periodic volume expansion of electrodes in the charging and discharging process directly affects the contact performance and interface impedance between the electrodes and the solid-state electrolyte(SSE).The existing work has studied the local stress state behavior on a single spatial scale or only focused on the interfacial influence of electrochemical characteristics at a specific *** this paper,a semi-analytical method-based chemoelastic contact model was developed to study the evolution behavior of the cathode/SSE interface,and the stress and displacement fields subjected to contact forces were calculated by means of the discrete convolution-fast Fourier transform *** interface evolution subjected to mechanical pressure was analyzed for the local influence of the stress at one position at a specified time on the contact behavior at the present time and position,and the global influence of those at other positions at a later *** on this model,the mechanical-chemical coupling effect of lithium intercalation on interface stability was quantitatively studied,and the mechanism of enhancing interfacial contact stability by mechanical load was further *** results show that a larger current causes the contact toward the center,while a larger mechanical force leads to a smaller pressure *** the increase in mechanical force,the compressive stress in the contact area decreases significantly,while the tensile stress outside the contact area increases *** on the model results,a transition map was constructed with bonder equation(P/I=25MPa·cm^(2)/mA)to define whether an interfacial contact is stable or ***,applying a mechanical pressure P/I>25MPa·cm^(2)/mA can maintain a stable interfacial contact between the SSE and the *** proposed model provides a theoretical basis in the chemomechanics view for the understanding of using pressure to suppress diffusion-induced contact

关键词： Solid-state battery Contact mechanics Chemoelastic coupling Cathode interface mechanical force

Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X(HBX)genetransfected hepatic stellate cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 499-512页

作者： Hongyi LIU Yuanyuan ZHOU Peng GUO Xiongwei ZHENG Weibin CHEN Shichao ZHANG Yu FU Xu ZHOU Zheng WAN Bin ZHAO Yilin ZHAO Department of Oncology and Vascular Interventional Radiology Zhongshan Hospital Affiliated to Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361004China School of Medicine Xiamen UniversityXiamen 361102China Xiamen Health and Medical Big Data Center Xiamen 361008China Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma(Zhongshan Hospital Affiliated to Xiamen University) Xiamen 361004China Xiamen Key Laboratory of Cellular Intervention and Interventional Medical Materials Xiamen 361004China

Artificial vascular graft(AVG)fistula is widely used for hemodialysis treatment in patients with renal ***,it has poor elasticity and compliance,leading to stenosis and *** ideal artificial blood vessel for dialysis should replicate the structure and components of a real artery,which is primarily maintained by collagen in the extracellular matrix(ECM)of arterial *** have revealed that in hepatitis B virus(HBV)-induced liver fibrosis,hepatic stellate cells(HSCs)become hyperactive and produce excessive ECM ***,mechanical stimulation can encourage ECM secretion and remodeling of a fiber *** on the above factors,we transfected HSCs with the hepatitis B viral X(HBX)gene for simulating the process of HBV ***,these HBX-HSCs were implanted into a polycaprolactonepolyurethane(PCL-PU)bilayer scaffold in which the inner layer is dense and the outer layer consists of pores,which was mechanically stimulated to promote the secretion of collagen nanofiber from the HBX-HSCs and to facilitate crosslinking with the *** obtained an ECM-PCL-PU composite bionic blood vessel that could act as access for dialysis after ***,the vessel scaffold was implanted into a rabbit’s neck arteriovenous fistula *** exhibited strong tensile strength and smooth blood flow and formed autologous blood vessels in the rabbit’s *** study demonstrates the use of human cells to create biomimetic dialysis blood vessels,providing a novel approach for creating clinical vascular access for dialysis.

关键词： Composite bilayer bionic blood vessel Extracellular matrix(ECM) Hepatic stellate cells(HSCs) Hepatitis B viral X(HBX)gene mechanical force

Role of the mechanical microenvironment in cancer development and progression

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Cancer Biology & Medicine 2020年第2期17卷 282-292页

作者： Qiuping Liu Qing Luo Yang Ju Guanbin Song Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400030China Department of mechanical Science and Engineering Nagoya UniversityNagoya 464-8603Japan

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in *** mechanical stress in tumors can alter the metabolism and behaviors of cancer cells and cause cancer cells to attain cancer stem-like cell properties,thus driving tumor progression and promoting *** mechanical signal is converted into a biochemical signal that activates tumorigenic signaling pathways through ***,we describe the physical changes occurring during reprogramming of cancer cell metabolism,which regulate cancer stem cell functions and promote tumor progression and ***,we highlight emerging therapeutic strategies targeting mechanotransduction signaling pathways.

关键词： Cancer stem cell cell metabolism mechanical force tumor progression

The RLCK-VND6 module coordinates secondary cell wall formation and adaptive growth in rice

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Molecular Plant 2023年第6期16卷 999-1015页

作者： Shaoxue Cao Yan Wang Yihong Gao Rui Xu Jianing Ma Zuopeng Xu Keke Shang-Guan Baocai Zhang Yihua Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing 100049China jiangsu Key Laboratory of Crop Genetics and Physiology/Key Laboratory of the Ministry of Education for Plant Functional Genomics College of AgricultureYangzhouUniversityYangzhou225009China

The orderly deposition of secondary cell wall(SCW)in plants is implicated in various biological programs and is precisely *** many positive and negative regulators of SCW have been documented,the molecular mechanisms underlying SCW formation coordinated with distinct cellular physiological processes during plant adaptive growth remain largely ***,we report the identification of Cellulose Synthase co-expressed Kinase1(CSK1),which encodes a receptor-like cytoplasmic kinase,as a negative regulator of SCW formation and its signaling cascade in *** deep sequencing of developing internodes and genome-wide co-expression assays revealed that CSK1 is co-expressed with cellulose synthase genes and is responsive to various stress *** increased SCW thickness and vigorous vessel transport in csk1 indicate that CSK1 functions as a negative regulator of SCW *** observation of green fluorescent protein-tagged CSK1 in rice protoplasts and stable transgenic plants,we found that CSK1 is localized in the nucleus and cytoplasm adjacent to the plasma *** and molecular assays demonstrated that CSK1 phosphorylates VASCULAR-RELATED NAC-DOMAIN 6(VND6),a master SCW-associated transcription factor,in the nucleus,which reduces the transcription of a suite of SCW-related genes,thereby attenuating SCW ***,genetic analyses show that CSK1 functions upstream of VND6 in regulating SCW ***,our physiological analyses revealed that CSK1 and VND6 are involved in abscisic acid-mediated regulation of cell growth and SCW *** together,these results indicate that the CSK1-VND6 module is an important component of the SCW biosynthesis machinery,which coordinates SCW accumulation and adaptive growth in *** study not only identifies a new regulator of SCW biosynthesis but also reveals a fine-tuned mechanism for precise control of SCW deposition,offering tools for rationally

关键词： RLCK signaling kinase fine-tuning regulator secondary cell wall biosynthesis mechanical force ABA adaptation

Targeting micromotion for mimicking natural bone healing by using NIPAM/Nb_(2)C hydrogel

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Bioactive Materials 2024年第9期39卷 41-58页

作者： Qianhao Yang Mengqiao Xu Haoyu Fang Youshui Gao Daoyu Zhu Jing Wang Yixuan Chen Department of Orthopedic Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China Eye Institute and Department of Ophthalmology Eye and ENT HospitalFudan UniversityShanghai200031China

Natural fracture healing is most efficient when the fine-tuned mechanical force and proper micromotion are *** mimick this micromotion at the fracture gap,a near-infrared-II(NIR–II)–activated hydrogel was fabricated by integrating two-dimensional(2D)monolayer Nb2C nanosheets into a thermally responsive poly(Nisopropylacrylamide)(NIPAM)hydrogel ***–II–triggered deformation of the NIPAM/Nb2C hydrogel was designed to generate precise micromotion for co-culturing *** was validated that micromotion at 1/300 Hz,triggering a 2.37-fold change in the cell length/diameter ratio,is the most favorable condition for the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Moreover,mRNA sequencing and verification revealed that micromotion-induced augmentation was mediated by Piezo1 *** of Piezo1 interrupts the mechano-sensitivity and abrogates osteogenic *** and femoral shaft defect models were established to explore the biocompatibility and osteoinductivity of the Micromotion Biomaterial.A series of research methods,including radiography,micro-CT scanning,and immunohistochemical staining have been performed to evaluate biosafety and osteogenic *** in vivo results revealed that tunable micromotion strengthens the natural fracture healing process through the sequential activation of endochondral ossification,promotion of neovascularization,initiation of mineral deposition,and combinatory acceleration of full-thickness osseous *** study demonstrated that Micromotion Biomaterials with controllable mechanophysical characteristics could promote the osteogenic differentiation of BMSCs and facilitate full osseous *** design of NIPAM/Nb2C hydrogel with highly efficient photothermal conversion,specific features of precisely controlled micromotion,and bionic-mimicking bone-repair capabilities could spark a new era in the field of regenerative medicine.

关键词： Micromotion BMSCs Osteogenesis mechanical force Regenerative medicine